There has been a start to a LuPIN trial in Australia run by a Professor Louise Emmett and a team which has produced interesting results so far. See the links at in post ..….
Its early days so far, but I've met Professor Emmett before the trial began when she was overseeing administering Lu177 to me and 3 others on my No 3 Lu177 shot. She was wanting to make the Lu177 work on more men because it does not work on all men, and maybe work better on the men where it does work. Who said women cannot be brilliant at what they do?
Patrick Turner.
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Patrick-Turner
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I'm not sure she accomplished what she set out to do. “All men received Dexamethasone 8 mg on Day 1 and 4 mg days 2,3.” These are very high doses and may be the reason for all of the PSA effect. In mCRPC patients who received just 1.5 mg/day of dexamethasone (a much lower daily dose), PSA decreased by > 50% in 61% of patients in this study (n=38):
Compared to this historical (1995) control, there is no evidence for an effect of Lu-177-PSMA-617 here, let alone for idronoxil. However, this 1995 study was before taxane chemo, and it is entirely plausible that chemo pretreatment may result in diminished potential to get the same magnitude of response to subsequent treatments. If that is the case, it may be that something other than dexamethasone had an effect here. It’s anyone’s guess until there is a randomized trial. I hope she will do one.
I just think we might have to wait and see what happens.
Prof Emmett thought that chemo and Lu177 had the effect of making Pca which had become resistant to ADT, Zytiga, Xtandi become re-sensitive to such things. She also said that Xtandi ( enzalutamide ) increased PsMa receptors so that more uptake of Lu177 would occur, thus make Lu177 more effective. She knew far more than I do, so maybe she's right. Many ideas are being tried around the world to beat Pca.
She was very positive about what might be ahead of me and said "I want you back on your bike asap," and I was tinkin' well, really, and the way my hip was going I thought yeah, two wheels = happy, but may have ta be a wheel chair.
Hip now agrees with sedentary life. 2 x 25mg diclonefen ( Voltaren) are needed though.
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Mixed results after two more Lu177 treatments
First injection of Lu177-PNT2002 as part of SPLASH trial
Lu177 Not Working
Zytiga and Lu177? So many confusing questions.
