Ralph- the FDA sets the limits for the various drugs re: the 3 pre cancerous contaminants found in those drugs. They don't have a limit for the 50mg, just for the 100mg Losartan.
You will have to click on the link at the bottom and see what they set for Losartan. But here is the issue: For eg., 100 mg Losartan the limit is given for the 3 contaminants. That means if the drug manufacturer, through their testing, find that their samples exceed those limits, then they have to voluntarily pull those lots off the market and alert the FDA who then alerts the medical profession. That is fine if that is what they do, but since 80% of the drugs come from India and China, there is a big ? if they are reporting as they should. But if their samples show just 1 number below that limit, they can then release those ingredients to the market, no problem and no alerting the FDA and no alerting to the medical profession. The doctors then assume those drugs are safe to use.
For instance one limit for Losartan for one of those 3 contaminants is .27ppm. .28ppm and the industry gets alerted, or they should be. BUT if the sample read .26ppm, that product is considered safe and no alerting any where. Because there is no alerting, the consumer doesn't know just how safe or contaminated his drug is. Neither does the Dr.. My PCP told me my current Losartan is safe to take.
In all fairness, here is what they say re: the danger of these drugs: " The acceptable intake is a daily exposure to a compound such as NDMA, NDEA, or NMBA that approximates a 1:100,000 cancer risk after 70 years exposure
** These values are based on a drug's maximum daily dose as reflected in the drug label"
So I guess a long "sphiel" with no conclusion for your question.
He just stopped that one....only I just asked my memory (my wife that is) why I stopped, and she said because Doctor said of it's interaction with Pca.
Cardiologist just stopped Losatan....only I just asked my memory (my wife that is) why I stopped, and she said because Cardiologist said of it's interaction with Pca.
Run this by your auto cerebroscope and see what you think of this theory.
Toprol is a Beta blocker- it relaxes the walls of the vessals.
Losartan is a ARB(it blocks the action of Angiotesin, which constricts the vessels.
I found that hot flashes have the following action: "As Figure 1 shows, there was a substantial decrease in blood pressure during the hot flash. "
Niacin with the "flushing" also dilates the blood vessels. So if you are having high Bp, then it would seem to me that taking flushing Niacin would work nicely with either of the two products mentioned above.
I have found that Losartan didn't bring my Bp down. It went from 197/110 to 128/78 at the ER over 3 hours time. I am going to combine my Losartan with Niacin when I see my Bp rising and see if that combo will keep the Bp down. So between the hot flashes, the Losartan and the Niacin, I should be able to keep the BP in good range.
Using my limited brain I would concur with you hypothesis that Losartan combined with Niacin should give you good results. So sic em.....
However I have a lung melanoma and stopped Losartan based upon the following:
Conclusion: Losartan inhibits NHE1 activity and the migration of human melanoma cells. At the same time, losartan promotes MV3 cell adhesion and invasion. The therapeutic use of AT1 antagonists (sartans) in hypertensive cancer patients should therefore be given critical consideration.
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