Is Trimix Safe?

[baw1955]

Hoping Tall_Allen will comment on this study. See Table 2, development of Peyronie's Disease is a significant predictor of discontinuation of intracavernosal injection (ICI) therapy -- Trimix being an ICI treatment.

onlinelibrary.wiley.com/doi...

[pjoshea13]

"While there is no direct link between the use of ICI and the development of tunical plaque, there is now a link established between RP and the development of Peyronie's Disease."

I remember reading accounts from Johns Hopkins, I think, of doctors being puzzled by Peyronie's-type issues months after prostatectomy [RP]. It was assumed that RP was somehow a cause.

A known risk factor for Peyronie's is Dupuytren's Contracture, which affects the hand, rather than the penis, but is otherwise very similar (& no, it cannot be transmitted via masturbation.)

Not long after my RP, I developed Dupuytren's. It developed very quickly & I soon had a locked 'trigger finger'. I went to a hand surgeon & he made the diagnosis. He didn't hold out much hope for a surgical solution (this was in 2005.)

At about the same time, I was reading that men with PCa often had low levels of iodine. When I began supplementation, I was astonished to find that my Dupuytren's reversed at about the same rate that it had progressed. I later read something by Dr. David Brownstein that claimed an association between iodine deficiency & Dupuytren's, Peyronie's (& also PCa).

I have been using Iodoral daily for 14 years, because I do not want a return of Dupuytren's. I don't know if it has any effect on my PCa.

Anyway, it occurred to me 14 years ago that the apparent RP-Peyronie's link might be spurious.

-Patrick

[jdm3 in reply to pjoshea13]

Most likely someone else in your family has/had Dupuytren's Contracture too. There is a strong genetic association. My wife has DC in her hands, but it is not too bad. Her father, and uncle (father was an identical twin), and cousins, etc... have it to varying degrees. When the doctor looked at her DC he just asked casually "anyone else in your family have this?"

I will mention the Iodoral to her and others. I'm sure they will be interested. Thanks.

[pjoshea13 in reply to jdm3]

I understand that there is a genetic issue - Dupuytren's is sometimes called the Viking's disease, but there are other populations too. However, there has been no-one in my family (to my knowledge.)

I have a neighbor who has had it for decades. Iodine was only able to halt progression. He still takes it, but opted for what was then a new treatment - injections to dissolve the lumps in his palm. It was partially successful & he was happy to get some relief.

My Dupuytren's reversed quickly, but it had come on quickly too.

-Patrick

[Hidden in reply to pjoshea13]

Great info! How much do you take of iodoral daily (and did you take more for Dupuytren's)? Did it reverse completely? Did you also put SSKI locally?

[pjoshea13 in reply to Hidden]

I started by painting iodine on the inner side of my upper arm before bedtime. The idea being that it would be totally absorbed by morning if there was deficiency. But I started seeing an integrative medicine doc at that time, & he advised the switch to oral Iodoral. I have taken one pill daily ever since (>13 years).

My aim was purely to maintain iodine sufficiency. I didn't double up on the dosage.

-Patrick

[Hidden in reply to pjoshea13]

12,5 mg i suppose?

[pjoshea13 in reply to Hidden]

Yes:

swansonvitamins.com/optimox...

-P.

[Currumpaw in reply to pjoshea13]

Some of us have different nutritional needs than others. Some need more and some need less. The ability to absorb nutrients is another factor.

Salt is bad--right? Iodine was added to salt because much of the US population was iodine deficient. Goiter!

Cutting salt intake means one should think about an iodine supplement.

Currumpaw

[pjoshea13 in reply to Currumpaw]

In the U.S., the fortification of salt is not mandatory, but most have access to iodized salt. The 'goiter belt' has disappeared, but the absence of goiters is not an indication of iodine sufficiency. That would be like using the absence of scurvey to prove vitamin C sufficiency.

Like many today, I do not add salt to food at the table. This is not because I think that salt is bad, but because I never developed a salt habbit. In any case, I don't care for the taste of iodized salt.

One study estimated that iodized salt raised the U.S. IQ by 15 points. After a PCa diagnosis, we could all use a few extra points to make sense of treatment options. LOL

In the U.K., access to iodized salt is quite spotty, but milk drinkers get enough due to iodine supplementation for cattle. I remember as a kid that at the mid-morning school break, we would head outside to the crates of free milk. Perhaps the best thing about that was the iodine. Margaret Thatcher put an end to that. Have IQ levels suffered, I wonder?

-Patrick

[Currumpaw in reply to pjoshea13]

Hey Patrick!

Okay! I supplement with Baar Nascent iodine daily. At least read the last couple paragraphs of this link. I couldn't help but think of your reply! A couple sentences that border on being politically very incorrect in the final paragraphs of the link! I was using Morton Sea Salt until the BP oil spill. Yes, I was mostly organic before the cancer.

The link:

Iodized salt changed life for those in the 'goiter belt ...

dispatch.com/article/200808...

BTW--goiter disappeared with the iodized salt.

Currumpaw

[pjoshea13 in reply to Currumpaw]

The greatest case for iodized salt was in Switzerland, where goiters were the least of it [1]:

"In certain regions of Switzerland, before prophylaxis, 0.5% of the inhabitants were cretins, almost 100% of schoolchildren had large goitres and up to 30% of young men were unfit for military service owing to a large goitre. Iodization of salt was introduced in 1922 at 3.75 mg I per kg and the iodine content was doubled twice, in 1962 and 1980, to the present 15 mg I per kg. In 1988, 92% of retail salt and 76% of all salt for human consumption (including food industry) was iodized, even though its use is voluntary. Urinary iodine excretion, previously between 18 and 64 micrograms per per day, has now risen to 150 micrograms per day. No new endemic cretins born after 1930 have been identified. Goitre disappeared rapidly in newborns and schoolchildren, more slowly in army recruits, and incompletely in elderly adults. In some Cantons (by constitution in charge of health matters and the salt monopoly) which allowed iodized salt only in 1952, disappearance of goitre lagged behind accordingly, proof that iodized salt was the cause of regression. The Swiss data provide evidence that isolated deafness, mental deficiency, and short stature, each without the other attributes of cretinism have also decreased. Adverse effects of iodized salt were minimal, possibly because the initial iodine content of salt was chosen very low. Iodization of salt has proved a highly cost-effective preventive measure in Switzerland."

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/228...

[Currumpaw in reply to pjoshea13]

Thanks! At least your article elevated the mental evaluation of those with iodine deficiency from "village idiots", (the article I sent you), to "cretins"! Your article. I think I would much rather be a cretin than a village idiot--! It does seem to be a step up! It is isn't it? Back to the serious conversations--darn it!

Currumpaw

[pjoshea13 in reply to Currumpaw]

Yes, Cretinism is specifically due to iodine deficiency, not in-breeding.

Interestingly, the village idiot, once common in remote European villages, became rare after the introduction of the bicycle. (The girls in the next village being more attractive, I suppose.)

Best, -Patrick

[407ca]

baw1955,

I use trimix. So far I have no issues. When I learned how to inject my uro emphasized only to use it once in 24 hour period. AND...to alternate injections between left and right. So far so good for me.

All the best

[TEBozo]

I had peyronie's and trimix failed. Penile implant 8/2013

[dadzone43]

One of the men in my support group developed this due to scarring. Even tho TriMix was effective, he decided to stop using it.