CT scan shows over 100 Bilateral sub centimeter solid and groundless nodules- Is this major concern? Anyone else had this?

Day of Prostate cancer stage 4 diagnosis in October 2018, CT scan showed over 100 bilateral sub centimeter solid and groundglass nodules consistent with metastases. Nodules are also seen along the pleura and fissures. No pleural effusions. Three 3 months later, there has been decreased in size of nodules to about 50%.

There is also scattered sclerotic metastases of the manubrium, clavicles, vertebral bodies and ribs for the CT chest scan upon diagnosis.

Are the nodules from the spread of prostate cancer or is this lung cancer?

Is this considered visceral mets? Is this called PC with mets to lungs and bones?

P.S. His diagnosis shows prostate cancer with bone mets.

[Drcrunch]

Solid ones are visceral metastasis and can be associated with prostate cancer as the primary. Sit down with your doctor and go over this so you have a clear understanding.

[cesanon]

"Three 3 months later, there has been decreased in size of nodules to about 50%."

Any reason to believe what may have caused this?

[Hidden]

He started Firmagon and Xgeva on October 23, 2018 than switched to Lupron and Xgeva every 3 months.

So most likely the medication

[Tall_Allen]

Pure ground glass nodules have to be watched for future development of primary lung cancer but are not cancerous. However, the shrinkage by 50% when he started hormone therapy raises suspicion that they may be metastases from prostate cancer. The only way to be certain is to meet with an interventional radiologist and get a biopsy. This is done in-bore with a CT scan, and is usually harmless if some nodules are in the periphery.

I just read an analysis that suggested that lung mets carry no worse prognosis than bone mets. Docetaxel may shrink them if they are from prostate cancer.

[Hidden in reply to Tall_Allen]

Would the treatment be the same as Prostate Cancer Stage 4 with extensive bone mets and lymph nodes involvement? If not, what else do you think should be added or deleted? Presently he is on Zytiga, Prednisone, Xygeva and Lupron. After 3 months on Zytiga, PSA dropped from 20 to 11. At diagnosis, PSA was 947. He will meet with Dr. Vogelzang in Las Vegas (hopefully next month)

[MichaelDD in reply to Tall_Allen]

TA is that an analysis that is available to read. Sitting at my Oncologists now . Thanks.

[Tall_Allen in reply to MichaelDD]

Here ya go:

clinical-genitourinary-canc...

[Db999 in reply to Tall_Allen]

Thanks for info. My only met was 11mm in lung and no other ...

[BarronS in reply to Tall_Allen]

Thank you.

[Tall_Allen]

I'd be surprised if Vogelzang didn't recommend docetaxel, since he was a lead investigator on the CHAARTED study.

[MichaelDD in reply to Tall_Allen]

Thank you!!

[Hidden]

He hasn't seen Vogelzang yet. His present MO never suggested docetaxel for him .