Anyone here on Spironolactone [Aldactone]?

[pjoshea13]

New paper below.

"Abiraterone and spironolactone in prostate cancer: a combination to avoid."

-Patrick

ncbi.nlm.nih.gov/pubmed/304...

Acta Clin Belg. 2018 Nov 26:1-6. doi: 10.1080/17843286.2018.1543827. [Epub ahead of print]

Abiraterone and spironolactone in prostate cancer: a combination to avoid.

Dhondt B1,2,3, Buelens S1,3, Van Besien J1, Beysens M1, De Bleser E1,2,4, Ost P2,4, Lumen N1,3.

Author information

1

a Department of Urology , Ghent University Hospital , Ghent , Belgium.

2

b Department of Radiation Oncology and Experimental Cancer Research , Laboratory of Experimental Cancer Research, Ghent University , Ghent , Belgium.

3

c Cancer Research Institute Ghent , Ghent , Belgium.

4

d Department of Radiation Oncology and Experimental Cancer Research , Ghent University Hospital , Ghent , Belgium.

Abstract

OBJECTIVES:

Disease progression in metastatic castration-resistant prostate cancer (mCRPC) is dependent on androgen signaling. This case describes the complex adaptive androgen signaling mechanisms in mCRPC and illustrates that caution should be exercised when treating these patients with drugs influencing the androgen axis.

METHODS:

Single case report and review of the literature.

RESULTS:

We report the case of an 86-year-old man with mCRPC, treated with the secondary antihormonal agent abiraterone acetate. Following association of spironolactone to deal with symptoms related to mineralocorticoid excess, biochemical and radiographic disease progression occurred. Spironolactone was discontinued and 8 months after withdrawal, the patient continues to show a biochemical response to abiraterone.

CONCLUSIONS:

Although spironolactone generally exerts anti-androgenic effects, experimental evidence exists that it acts as an androgen receptor agonist in an androgen-depleted environment, capable of inducing prostate cancer proliferation. This is supported by the observations described in this case report. Therefore, spironolactone should be avoided in prostate cancer patients suffering from treatment-associated side effects of abiraterone.

KEYWORDS:

Abiraterone; CYP17; androgen receptor; mineralocorticoid excess; prostate cancer; spironolactone

PMID: 30477405 DOI: 10.1080/17843286.2018.1543827

[Abiathar]

Thanks for the article. Spironolactone has become a very common drug used in the treatment of congestive heart failure so there are probably many on both drugs.

Abiathar

[pjoshea13 in reply to Abiathar]

Abiathar,

Thanks for that info. One tends to focus on PCa without regard to comorbidities & the many drugs commonly prescribed to older men (at least in America).

-Patrick

[j-o-h-n in reply to pjoshea13]

If it had an "S" on the end it would sound like my Greek School teacher.

Good luck, Good Health and Good Humor.

j-o-h-n Thursday 11/29/2018 6:27 PM EST