New study below [1].
The androgen receptor [AR] remains the favorite target. We deprive them of androgen & gum them up with antiandrogens. We can target AR overexpression or accelerate AR decay.
"Riluzole (marketed as Rilutek and Teglutik) is a drug used to treat amyotrophic lateral sclerosis." [2]
Riluzole "downregulates AR-FL, mutant ARs, and AR-V7 proteins expression by protein degradation".
"Riluzole also significantly inhibited AR transcription activity by decreasing its target genes expression (PSA, TMPRSS2, and KLK2)."
-Patrick
