Life extension supplements

[podsart]

Those of us who order Life Extension supplements may have read their magazine. I know the “studies” included in this magazine are mostly to drive sales, however, I was wondering what any of you think about these studies, in terms of clinical validity.

[cesanon]

1. They have a good reputation for quality of product. Their suppliers reportedly gripe about their rigorous testing and willingness to return non-complying product for non material failings.

2. But the world is way too complicated to drink their self serving research. Never rely on vendor research.

Once you have done your own research, they should probably be your favored vendor.

[podsart in reply to cesanon]

Thanks

[Tall_Allen]

I don't have a single kind word for them - Their "research" is not, well, research. And if you follow the links in the studies they offer, you will find that they are mostly just lab studies, and even ten, they bend what the researchers actually said and did. I think hey do a LOT of damage.

[podsart in reply to Tall_Allen]

Thanks

[pjoshea13]

I think that the LEF mag is a very good place to pick up information. For most men, going directly to studies via PubMed is not a good option. LEF does a good job of selecting studies, I feel. You often see over a score of citations. If they were to cherry pick on the basis of a view that goes against the body of evidence, you would see only a few citations.

I decided to look at what LEF says about boron & PCa (I chose boron only because it was the first alphabetic topic I thought of):

lifeextension.com/Magazine/...

There are 40 citations in the 2015 article. Currently on PubMed there are 54 hits.

My post of 2 years ago - "Foods/Supplements-Vitamins: Boron" - cited 11 studies, 5 of which were also used by LEF.

Has there been a PCa prevention study using boron? Of course not, & it would be foolish to hold one's breath. You use what evidence you can find.

Are we to ignore PCa cell line studies, animal model studies, epidemiological studies, etc?

Note (from Wiki) "The amount of boron required by animals and humans is not yet well established." So perhaps we should ignore boron altogether?

-Patrick

[Tall_Allen in reply to pjoshea13]

"Are we to ignore PCa cell line studies, animal model studies, epidemiological studies, etc?" Now you're getting it! Those studies were never designed for patients to take therapy advice from. They are meant to generate hypotheses for the next round of (hopefully, clinical) research. It is especially dangerous when patients blithely ignore the danger signals of those initial studies. This is why all professional researchers, journals and associations conform to "levels of evidence" guidelines.

[pjoshea13 in reply to Tall_Allen]

I think that most of us know that. The issue is that with PCa death within a short number of years being a common event in the advanced population, some are willing to take the risk. There is no "cure" for men with mets. Even treatment for oligometastatic disease has not been "proven" to result in a cure.

By constantly repeating the message that there is nothing that we can do - neither supplements not diet - not even metformin or vitamin D - you send a chilling message to this group.

-Patrick

[podsart in reply to pjoshea13]

This Pca thing is some tough stuff

[Tall_Allen in reply to pjoshea13]

I hope that is NOT the message I send. There are no known supplements (with the exception of sulforophane) or dietary changes that have been shown to make a difference in PC outcomes. That doesn't mean there is nothing a patient can do. In fact, I regularly write about the late-breaking developments for PC treatments, and have been a consistent advocate for them. Vitamin D has serious associated safety issues; metformin does not. Unlike you, I am discerning about what I advocate, and I pay attention to ALL the research data - not just those that confirm my biases. You should be aware of the potential harm you do.

[curt504a in reply to pjoshea13]

Given list of dangerous and hardly useful drugs through the "gold standard" the FDA runs (pay ola included) I feel LEF.org is the lone star in the nutrical market. Been a member for 10+ yrs, buy there stuff, also read their magazine and buy it else where. But the truth is they return a percent of their profit back into research to buying from LEF is to me like subscribing to consumer reports. And of sorts they are a bit like CR.

BTW I get all my blood tests via LEF.org. A fraction of the cost as via a DR and all by LabCorp the same tests just cheaper.

[Shooter1]

Researched them some. Ordered nothing. Do they have some good stuff? maybe?

Doug

[podsart in reply to Shooter1]

Shooter1

I was a Dr Myers patient and for the years I was with him he prescribed a number of life extension supplements; seems like he felt that they sold their product with purity checks and stable doses in accordance with what they advertised

For these items , i still am taking them

[Shooter1 in reply to podsart]

Which supplements do you get from them?? My onc. didn't recommend any specific brand or dose. Got most of my info here. Could use some more. Thanks

Doug.

[podsart in reply to Shooter1]

Curcumin, resveratrol, pomegranate melatonin, soy isoflavones, vitamin D, I split day resveratrol life extension and night dose nitro (its expensive)

[homer13 in reply to podsart]

Didn't Snuffy recommend Jarrow for Curcumini.?

[podsart in reply to homer13]

Interesting, no he didn’t; however, I am getting the sense from this site that he didn’t keep up with my supplements as diligently as his other patients

Can u tell me which jarrow curcumin he changed to and what dose he wanted?

Do u remember any other changes he made; perhaps there are other ones I missed?

[homer13 in reply to podsart]

Jarrow Curumin 95

Resveratrol - Nitro 250

He too Pomegranate off the list when I saw him in August. He said that studies didn't confirm the efficacy

[podsart]

Thanks