Attacking treatment-resistant prostate cancer by blocking its stress response

[JLS1]

Another article on what's been posted here over the last few days:

Attacking treatment-resistant prostate cancer by blocking its stress response

by Arlene Weintraub | May 2, 2018 2:00pm

fiercebiotech.com/research/...

"Several companies and academic research centers are pursuing new technologies aimed at combating aggressive prostate cancer. Tmunity Therapeutics, for example, is working on a CAR-T treatment for prostate cancer and recently pulled in a $100 million series A to help fund that research. The rise of DNA sequencing has pointed to several new targets in the disease, including mutations in BRCA1 and BRCA2 that could open up the possibility of treating aggressive cases with PARP inhibitors.

To test the potential of ISRIB, the UCSF researchers implanted cells from a prostate cancer treatment into mice and showed they could shrink the tumors with the drug. ISRIB also extended survival, they reported, and normal cells were unaffected. They believe the findings should be used to design trials of ISRIB in patients with aggressive prostate tumors.."