New study below .
Years ago, when I had salvage radiation, I was not on Simvastatin, but I was by the time a lesion at L5 was treated.
From the new paper:
"These findings reveal that simvastatin may be a potent therapeutic agent for co-treatment with radiation to overcome radioresistance in PCa cells."
Radioresistance is a recognized problem of diminishing returns. Survival escape paths have been identified & there are some natural substances that might help during treatment:
 Resveratrol (2012).
 Metformin (2014).
[4a] [4b] [4c] Genistein (2001, 2008, 2009).
Note that genistein has been found to have a biphasic effect in PCa & BCa. Avoid low doses - use only very high doses.
[5a] [5b] [5c] Curcumin (2004, 2016, 2017).
Front Pharmacol. 2018 Jun 13;9:600. doi: 10.3389/fphar.2018.00600. eCollection 2018.
Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair.
Chen YA1, Shih HW1, Lin YC1, Hsu HY1, Wu TF2, Tsai CH3, Wu CL4,5, Wu HY3, Hsieh JT6, Tang CH1,7, Lai CH1,3,5,8.
Graduate Institute of Basic Medical Science, School of Medicine, China Medical University, Taichung, Taiwan.
Department of Applied Cosmetology, Hung Kuang University, Taichung, Taiwan.
Department of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Department of Biochemistry, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Molecular Infectious Disease Research Center, Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan.
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Graduate Institute of Biomedical Sciences, School of Medicine, China Medical University, Taichung, Taiwan.
Department of Nursing, Asia University, Taichung, Taiwan.
Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, are commonly used to treat hypercholesterolemia, exhibiting beneficial effects on cardiovascular diseases and on several types of cancers, including PCa. However, the mechanistic details and crosstalk between statins and RT in PCa cells remain unknown. In this study, radioresistant DOC-2/DAB2 interactive protein (DAB2IP)-deficient PCa cells were used to evaluate whether simvastatin could enhance the effect of ionizing radiation (IR). The crucial molecules that associated with simvastatin elevated radiosensitivity in PCa cells were explored. Our results demonstrated that a combination treatment with simvastatin and IR synergistically induced apoptosis of radioresistant PCa cells. In addition, simvastatin appeared to compromise DNA double-strand breaks repair by activating the expressions of histone 2A family member X (γ-H2AX) and phospho-checkpoint kinase 1 (p-CHK1), suggesting an underlying mechanism for this radiosensitization of PCa cells. These findings reveal that simvastatin may be a potent therapeutic agent for co-treatment with radiation to overcome radioresistance in PCa cells.
DNA double-strand break; HMG-CoA reductase; cholesterol; prostate cancer; radioresistance; simvastatin
PMID: 29950990 PMCID: PMC6008406 DOI: 10.3389/fphar.2018.00600