Advanced Prostate Cancer
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ADT & Herpes

New study.

Has herpes zoster after ADT initiation been an issue for the group?

"... the adjusted hazard ratio for an HZ attack during the 3-year follow-up period for patients with PC who had received ADT was 1.88 ..."

I don't suppose that number means much. The study is Taiwanese & there is no mention of the percentage of men who harbor HZ.

I did a search for <prostate adt shingles> & the same paper came up (nothing else), must be mentioned in the full text.

-Patrick

onlinelibrary.wiley.com/doi...

Summary

This study aimed to examine the association of herpes zoster (HZ) with androgen deprivation therapy (ADT) use among patients with prostate cancer (PC), using a population-based data set. The study sample for this study was retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We selected 877 patients with PC who had received ADT as the study group, while 849 patients with PC who had not received ADT served as the comparison group. Each study patient was individually tracked for a 3-year period to discriminate those who subsequently received a diagnosis of HZ. Of the total 1,726 sampled patients, the incidence rate of HZ per 100 person-years was 1.80 (95% CI: 1.41–2.25) during the 3-year follow-up period. In particular, incidence rates of HZ per 100 person-years were 2.36 (95% CI: 1.75–3.13) and 1.24 (95% CI: 0.81–1.81), respectively, for patients with PC who had and those who had not received ADT. Furthermore, Cox proportional hazard regressions showed that the adjusted hazard ratio for an HZ attack during the 3-year follow-up period for patients with PC who had received ADT was 1.88 (95% CI: 1.13–3.11) than those who had not received ADT. We concluded that patients with PC who had received ADT had an increased risk of HZ.

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Intetresting

Rich

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after 10 years on ADT my husband got the worst case of shingles...so bad, that his doctors thought it had to be something else. after the skin tests came back and it was determined that it was indeed shingles, they told him that he couldn't even take an antiviral to lessen the devastation because he had just started docetaxel...and the chemo probably brought it on...since it lowered his immunity.

one doctor did mention that even though the chemo was the culprit, the ADT probably turned it into the worse case ever. i never thought to question him as to why he thought that.

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Like the question "What's the difference between love and herpes?" answer "herpes is forever!"

j-o-h-n Saturday 08/12/2017 11:30 AM EST

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