Tenovus PhD student breast cancer breakthrough - Tenovus

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Tenovus PhD student breast cancer breakthrough


We are delighted that one of our PhD Students, Luke Piggott from Cardiff University, has had his research published in the Breast Cancer Research journal. Luke has found a way to selectively destroy breast cancer stem cells, which could help prevent the disease from spreading.

His supervisor, Dr Richard Clarkson from Cardiff University School of Biosciences, has said “Only a small portion of cells within a tumour are responsible for metastatic spread and disease relapse. There is a promising new class of anti-cancer drugs called TRAIL-receptor antagonists that can selectively kill cancer cells whilst sparing healthy normal cells. We have used this agent to successfully sensitise cancer stem cells; this was particularly surprising because the majority of breast cancers are resistant to this drug.”

Luke has found that by using this method, he has achieved a 98 per cent reduction in secondary tumours in the laboratory.

To watch a YouTube video of Luke discussing his research please see:

We currently have nine PhD studentships in Wales, with a further ten due to start in September. If you would like more information about our PhD studentship please visit our website: tenovus.org.uk/research/phd...

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There are so many different types of breast cancer, with different receptors. Would this treatment prevent ALL types of breast cancer from spreading? I'm cancer free at the moment, but my risk for a recurrence is less than 20% in my chest wall (due to having a mastectomy) but 50% in my lymph nodes. For which I would have to have an axillary clearance. It would be reassuring to know there was something that could stop it from spreading further.