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Xtandi
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What first?: Provenge or Nubeqa?
Following this treatment, many physicians are using abiraterone acetate (Zytiga) in the prechemotherapy space with the possibility of also administering enzalutamide (
Xtandi
) in the future.
Following this treatment, many physicians are using abiraterone acetate (Zytiga) in the prechemotherapy space with the possibility of also administering enzalutamide (
Xtandi
) in the future.
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
How to interpret PSA results
His oncologist said several months ago that he will likely start him on
Xtandi
or similar, but hasn’t yet. Thank you for your input! Dana
His oncologist said several months ago that he will likely start him on
Xtandi
or similar, but hasn’t yet. Thank you for your input! Dana
DDCD
in
Advanced Prostate Cancer
1 year ago
Next treatment options
Lupron + Zytiga or
Xtandi
, no chemo (I've previously not had
Xtandi
) or 2. Lupron + Lynparza, no chemo (I have BRCA2 mutation) Please share any thoughts and suggestions on the next treatment options. Thank you for your kind consideration!
Lupron + Zytiga or
Xtandi
, no chemo (I've previously not had
Xtandi
) or 2. Lupron + Lynparza, no chemo (I have BRCA2 mutation) Please share any thoughts and suggestions on the next treatment options. Thank you for your kind consideration!
MechD
in
Advanced Prostate Cancer
2 years ago
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PSA 0.1 two test in a row good?
Started at 79 in in January 2021...on Lupron and
xtandi
should i be doing anything else...20 rounds of radiation to prostate in September 2021...
Started at 79 in in January 2021...on Lupron and
xtandi
should i be doing anything else...20 rounds of radiation to prostate in September 2021...
rogerandme
in
Advanced Prostate Cancer
2 years ago
An Update for the Community
He started LU177 in September, after
Xtandi
stopped working, with a PSA of around 16. After one infusion, his PSA was 2.8 and after two infusions, it was .8 so I think we can say this is going very well for him. As for me, I spent much of 2022 getting Cabazitaxel and Carboplatin--nine cycles!
He started LU177 in September, after
Xtandi
stopped working, with a PSA of around 16. After one infusion, his PSA was 2.8 and after two infusions, it was .8 so I think we can say this is going very well for him. As for me, I spent much of 2022 getting Cabazitaxel and Carboplatin--nine cycles!
StePeteMN
in
Advanced Prostate Cancer
1 year ago
PSA is increasing after 11 cycle of Docetaxel, what should we do now ?
I'm leaning forward
Xtandi
and we can try to sort out the financial bits of it, but I got 2 questions: 1) is there something better we should try or ask his MO about other than
Xtandi
? 2) is there any financial aid programs for
Xtandi
either from Astellas or any other institution ?
I'm leaning forward
Xtandi
and we can try to sort out the financial bits of it, but I got 2 questions: 1) is there something better we should try or ask his MO about other than
Xtandi
? 2) is there any financial aid programs for
Xtandi
either from Astellas or any other institution ?
mgaa
in
Advanced Prostate Cancer
1 year ago
thank you for your help. Wondering what’s next after xtandi and starting zytiga + prednisone
Has anyone become or known anyone who became resistant to
xtandi
and the started aberitone + prednisone and what happens next. Chemo, I suppose if you want. Seems like heavy duty stuff! What does that look like and for how long?
Has anyone become or known anyone who became resistant to
xtandi
and the started aberitone + prednisone and what happens next. Chemo, I suppose if you want. Seems like heavy duty stuff! What does that look like and for how long?
Hereformydad2022
in
Advanced Prostate Cancer
1 year ago
Xtandi Superior to Zytiga? Maybe Yes? Xtandi prevents resistance to Testosterone because it upregulates the AR while inhibiting its activity
There is no downside to choosing
Xtandi
instead of Zytiga. Each may have side effects that are unique to the individual patient, but you don't know until you try. There is some anecdotal evidence that
Xtandi
side effects may be more common than Zytiga. 2.
There is no downside to choosing
Xtandi
instead of Zytiga. Each may have side effects that are unique to the individual patient, but you don't know until you try. There is some anecdotal evidence that
Xtandi
side effects may be more common than Zytiga. 2.
cesanon
in
Advanced Prostate Cancer
2 years ago
No more free Zytiga
My MO is switching me to
Xtandi
and we're applying to Pfizer for a similar program. I've been on a half-dose (500 mgs) of Zytiga for more that five years and remain undetectable.
My MO is switching me to
Xtandi
and we're applying to Pfizer for a similar program. I've been on a half-dose (500 mgs) of Zytiga for more that five years and remain undetectable.
npaulson1
in
Advanced Prostate Cancer
2 years ago
OK, a little good news , what is next?
I was getting myself geared up for
xtandi
or zytiga on top of ADT but now I feel i may not need it and maybe should stay the course? No pain just hot flashes and feeling ok and exercise daily. I want to be proactive!! I think this site is the best broad form of info out there!!
I was getting myself geared up for
xtandi
or zytiga on top of ADT but now I feel i may not need it and maybe should stay the course? No pain just hot flashes and feeling ok and exercise daily. I want to be proactive!! I think this site is the best broad form of info out there!!
rick8637
in
Advanced Prostate Cancer
2 years ago
Totally confused after Onc visit today and rather alarmed
Started Firmagon and PSA plummeted to 36.2 in Dec. 2021 and descended each month until May 2022 when it began rising again to a high in July 2022 of 23.69 at which time I began Orgovyx and
Xtandi
.
Started Firmagon and PSA plummeted to 36.2 in Dec. 2021 and descended each month until May 2022 when it began rising again to a high in July 2022 of 23.69 at which time I began Orgovyx and
Xtandi
.
GSDF
in
Advanced Prostate Cancer
1 year ago
Triplet therapy after nadir?????
I assume that there are millions of cancer cells now being held in check by Zoladex and
Xtandi
, but I don’t know if there is any non-PSA growth going on. We have recently established that triplet therapy is a good thing to hit PCa with just after diagnosis.
I assume that there are millions of cancer cells now being held in check by Zoladex and
Xtandi
, but I don’t know if there is any non-PSA growth going on. We have recently established that triplet therapy is a good thing to hit PCa with just after diagnosis.
Stoneartist
in
Advanced Prostate Cancer
1 year ago
not sure my Onco (or I)understood the Denmeade BAT paper.
Last week, after 3months of 160mg/day
Xtandi
my PSA was 72. Three months ago I gave my Onco the Denmeade review paper on BAT and yesterday he directed me as follows: Stop
Xtandi
and take 250mg of testosterone per week for 6 weeks after which plan is to restart
Xtandi
or ???
Last week, after 3months of 160mg/day
Xtandi
my PSA was 72. Three months ago I gave my Onco the Denmeade review paper on BAT and yesterday he directed me as follows: Stop
Xtandi
and take 250mg of testosterone per week for 6 weeks after which plan is to restart
Xtandi
or ???
Frigataflyer
in
Advanced Prostate Cancer
2 years ago
When is enzalutamide going generic? DAROLUTAMIDE?
DrugPatentWatch® Litigation and Generic Entry Outlook for
Xtandi
. A generic version of
XTANDI
was approved as enzalutamide by APOTEX on April 22nd, 2022. Nubeqa aka Darolutamide will be eligible for patent challenges on July 30, 2023.
DrugPatentWatch® Litigation and Generic Entry Outlook for
Xtandi
. A generic version of
XTANDI
was approved as enzalutamide by APOTEX on April 22nd, 2022. Nubeqa aka Darolutamide will be eligible for patent challenges on July 30, 2023.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
missed the boat on triplet therapy?
My question is would there be any benefit of adding one of agents (zytiga,
xtandi
, nubeqa) at this point or would we not really obtain the summative effects/should we just at this point wait for a progression since he isnt treatment naive anymore? tia
My question is would there be any benefit of adding one of agents (zytiga,
xtandi
, nubeqa) at this point or would we not really obtain the summative effects/should we just at this point wait for a progression since he isnt treatment naive anymore? tia
Idyllwild
in
Advanced Prostate Cancer
2 years ago
MO Stopped Treatments
His MO stopped his chemo as he was only taking 1-2-1-2 (
Xtandi
- alternating days) when the full dose is 4 tablets a day. He no longer wishes to do full dose chemo if any sort. He is taking a hormone injection monthly but it appears to have stopped working as well.
His MO stopped his chemo as he was only taking 1-2-1-2 (
Xtandi
- alternating days) when the full dose is 4 tablets a day. He no longer wishes to do full dose chemo if any sort. He is taking a hormone injection monthly but it appears to have stopped working as well.
drb1966
in
Advanced Prostate Cancer
10 months ago
Xtandi Enzalutamide
My husband was on
Xtandi
. It was not effective, so he stopped taking it. However, he has a bottle of the tablets that are still in the sealed box (Exp 8/24). He received them through his insurance so the cost to him was minimal, but it is a very expensive drug if one does not have insurance.
My husband was on
Xtandi
. It was not effective, so he stopped taking it. However, he has a bottle of the tablets that are still in the sealed box (Exp 8/24). He received them through his insurance so the cost to him was minimal, but it is a very expensive drug if one does not have insurance.
Epikos
in
Advanced Prostate Cancer
2 years ago
Why does BAT work in so few?
https://www.jci.org/articles/view/162396 They are running a clinical trial to test cycling between T and
Xtandi
, after Zytiga failure. https://clinicaltrials.gov/ct2/show/NCT04363164
https://www.jci.org/articles/view/162396 They are running a clinical trial to test cycling between T and
Xtandi
, after Zytiga failure. https://clinicaltrials.gov/ct2/show/NCT04363164
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
next step more Lupron?
Is there any reason not to take a break and restart Lupron and
Xtandi
if my numbers start going back up? Suggestions ?
Is there any reason not to take a break and restart Lupron and
Xtandi
if my numbers start going back up? Suggestions ?
GJ65
in
Advanced Prostate Cancer
2 years ago
Painful Mets to ribs. Radiation or operation.
Just starting third week of
xtandi
. Psa after docetaxel 8 psa after Cabazitaxel 150. Has anybody else undergone treatment for back Mets and if so what did you/they have. Have a bed beside him in hospital.
Just starting third week of
xtandi
. Psa after docetaxel 8 psa after Cabazitaxel 150. Has anybody else undergone treatment for back Mets and if so what did you/they have. Have a bed beside him in hospital.
Hidden
in
Advanced Prostate Cancer
1 year ago
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