Experiences with

Incivek

the MALACHITE I and II clinical studies, where patients with HCV genotype 1a or 1b without cirrhosis were dosed with Exviera (dasabuvir, AbbVie) in combination with Viekirax (ombitasvir/paritaprevir/ritonavir, AbbVie) with or without ribavirin, and compared with patients treated with a combination of Incivek

The Phase II C-SALVAGE trial included 79 people who had failed a previous regimen of interferon, ribavirin and either Olysio (simeprevir), Incivek (telaprevir) or Victrelis (boceprevir). Results were presented at the 50th International Liver Congress in Vienna, Austria.

My treatment went fairly smoothly after I finished the Incivek in late December. As you may recall, I suffered greatly with the nausea from the Incivek. It was very, very hard. Since that ended in December, I have been relatively side effects free.

I started on October 4th and did 12 weeks of Incivek with the Riba and Interferon. I am now just on the Riba and Interferon. Since the Incivek ended, I have had absolutely no side effects from the other drugs. I feel better today than I have in a long time.

We are hoping that since the Incivek is stopped and I am feeling so much better, my Hemoglobin may go back up. If it doesn't, they will reduce my Ribavirin dose.

It seems that since I started taking my Incivek twice a day with 3 pills each time instead of 3 times a day with 2 pills each time, I have been much sicker. I don't know if this is because of the change in the dosing or not.

Also, I now have only 3 weeks left of the Incivek!!!!!! I can't tell you how happy I will be to end that drug. It has been the worst time for me on this. I am just so thankful that I only have to take it for the first 12 weeks of treatment.

She said that I am now able to take my Incivek only two times a day. That means that instead of taking two pills, three times a day, I would now take three pills, two times a day. Now, this is very big!!!!

As you may know, I am just ending my 6th week of triple therapy, Incivek, Peg and Riba. The first week or so was pretty good....wouldn't even know I was doing treatment. Ever since about the 2nd week of treatment I have been experiencing a lot of side effects.

That means I am halfway through my time for Incivek. I will be so glad when that drug is done!!!! I think that is the one making me sick and feeling so bad. I have been told by others that once you stop taking the Incivek and having to eat so much fat, you will feel better.

I must admit, the time has gone by fairly quickly and I am counting down the weeks until I no longer have to take the Incivek. I only take that for the first 12 weeks and I can tell you that I will be one happy camper to end that.

: ) The other idea I had (and again, it may be the drugs talking) is that it might be a good idea if a Registered Dietician was made available for people starting the triple therapy treatment (Incivek).

He also made some homemade peanut butter cookies that I can take for my high fat Incivek time. They are so delicious and easy to eat. What would I do without him???? I couldn't get through these hard times, I just know it. Later in the evening my lower back began to hurt.

The biggest problem for me with this treatment is the fact that I have to ingest a minimum of 20 grams of fat three times a day with my Incivek pills.

s Victrelis and Incivek from Vertex Pharmaceuticals Inc. and Johnson & Johnson. Both significantly improve the cure rate over what has long been the standard of care, a mix of injections and pills with nasty side effects that takes several months and still doesn't cure many patients.

I will be taking my next two pills of Incivek at 11 p.m. tonight. Again, I have to take with fatty food. I stopped at Sobey's on my way home from the clinic and picked up a bunch of stuff I can eat with these pills.

One other thing that is a bit bothersome is the fact I have to have 20 grams of fat when I take my Incivek pills, three times a day: 6:30 a.m., 3:00 p.m. and 11:00 p.m. I have been experimenting with different ways of getting this fat without all the calories and the "bad" fat.