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Enzalutamide
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Indomethacin / Xtandi
Furthermore, the combination of indomethacin and
enzalutamide
resulted in significant inhibition of
enzalutamide
-resistant tumor growth.
Furthermore, the combination of indomethacin and
enzalutamide
resulted in significant inhibition of
enzalutamide
-resistant tumor growth.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
AR-V7 & Xtandi resistance. PIP5K1α & ISA-2011B.
[Epub ahead of print] Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes
enzalutamide
resistance in prostate cancer cells.
[Epub ahead of print] Targeted suppression of AR-V7 using PIP5K1α inhibitor overcomes
enzalutamide
resistance in prostate cancer cells.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
History of my journey
Abiraterone (had to come off for toxicity reasons),
Enzalutamide
and now cabazitaxel.
Abiraterone (had to come off for toxicity reasons),
Enzalutamide
and now cabazitaxel.
HughVG
in
Fight Prostate Cancer
8 years ago
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Galeterone for the treatment of advanced prostate cancer: the evidence to date
Meanwhile, additional Phase II trials are being planned using galeterone in the post-abiraterone and post-
enzalutamide
populations.
Meanwhile, additional Phase II trials are being planned using galeterone in the post-abiraterone and post-
enzalutamide
populations.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Neutrophil to Lymphocyte Ratio, Xtandi, & Outcome in CRPC
"A persistent NLR >3 during treatment with
enzalutamide
seems to have both A persistent NLR >3 during treatment with
enzalutamide
seems to have both prognostic and predictive value in CRPC patients. value in CRPC patients."
"A persistent NLR >3 during treatment with
enzalutamide
seems to have both A persistent NLR >3 during treatment with
enzalutamide
seems to have both prognostic and predictive value in CRPC patients. value in CRPC patients."
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Cost-savings analysis of AR-V7 testing in mCRPC patients eligible for treatment with abiraterone or enzalutamide
METHODS: We calculated the cost savings of performing AR-V7 testing in mCRPC patients prior to starting abiraterone/
enzalutamide
(and avoiding these drugs in AR-V7(+) men) versus treating all mCRPC patients empirically with abiraterone/
enzalutamide
(without use of the biomarker).
METHODS: We calculated the cost savings of performing AR-V7 testing in mCRPC patients prior to starting abiraterone/
enzalutamide
(and avoiding these drugs in AR-V7(+) men) versus treating all mCRPC patients empirically with abiraterone/
enzalutamide
(without use of the biomarker).
pjoshea13
in
Advanced Prostate Cancer
8 years ago
AR-V7
"The purpose of this study is to compare galeterone to
enzalutamide
in men expressing androgen receptor spice variant-7 mRNA (AR-V7) in metastatic (M1) castrate resistant prostate cancer (CRPC).
"The purpose of this study is to compare galeterone to
enzalutamide
in men expressing androgen receptor spice variant-7 mRNA (AR-V7) in metastatic (M1) castrate resistant prostate cancer (CRPC).
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Glenn from mississauga ont canada with advanced prostate cancer
- 2011 bang advanced prostate cancer out of the blue at 54 - gleason 9.5 mets to hips and spine, in lympnodes - tried most things zoledex, abiraterone (Zytiga®), Docetaxel (Taxotere®) Cabazitaxel (Jevtana®), radium 223,
Enzalutamide
, xgeva,zometa, - on my 3rd round of chemo Docetaxel and Carbplatin
- 2011 bang advanced prostate cancer out of the blue at 54 - gleason 9.5 mets to hips and spine, in lympnodes - tried most things zoledex, abiraterone (Zytiga®), Docetaxel (Taxotere®) Cabazitaxel (Jevtana®), radium 223,
Enzalutamide
, xgeva,zometa, - on my 3rd round of chemo Docetaxel and Carbplatin
glennporemba
in
Advanced Prostate Cancer
8 years ago
Significance of early PSA response.
KEYWORDS: Abiraterone;
Enzalutamide
; PSA; Prostate cancer PMID: 27151554 [PubMed - as supplied by publisher]
KEYWORDS: Abiraterone;
Enzalutamide
; PSA; Prostate cancer PMID: 27151554 [PubMed - as supplied by publisher]
pjoshea13
in
Advanced Prostate Cancer
8 years ago
New here, diagnosed age 52, Gleason 10
. -09/25/2013- ADT started (Lupron) -02/5/14- started MDV3100-09 (STRIVE): A Multicenter Phase 2, Randomized, Double-Blind, Efficacy and Safety Study of
Enzalutamide
vs.
. -09/25/2013- ADT started (Lupron) -02/5/14- started MDV3100-09 (STRIVE): A Multicenter Phase 2, Randomized, Double-Blind, Efficacy and Safety Study of
Enzalutamide
vs.
Glsn10
in
Advanced Prostate Cancer
8 years ago
Retinoic acid receptor–related orphan receptor γ (ROR-γ) & the Androgen Receptor (AR)
"ROR-γ antagonists suppressed tumor growth in multiple AR-expressing, but not AR-negative, xenograft PCa models, and they effectively sensitized CRPC tumors to
enzalutamide
, without overt toxicity, in mice."
"ROR-γ antagonists suppressed tumor growth in multiple AR-expressing, but not AR-negative, xenograft PCa models, and they effectively sensitized CRPC tumors to
enzalutamide
, without overt toxicity, in mice."
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Metatstatic PCA to lymphs, bones & lung
Enzalutamide
has brought his PSA down to 15, the lowest that it has been for 5 years. He is now on a bit of a plateau. I have read a bit about Metformin and wondered if this was possibly something that could be added. Any comments/ observation would be most welkcome. Thanks, Carol2
Enzalutamide
has brought his PSA down to 15, the lowest that it has been for 5 years. He is now on a bit of a plateau. I have read a bit about Metformin and wondered if this was possibly something that could be added. Any comments/ observation would be most welkcome. Thanks, Carol2
Carol2
in
Advanced Prostate Cancer
9 years ago
Xtandi ?
Cost of Xtandi (
enzalutamide
) Diagnosed in 2000 at age 61. PSA 5.6. Radical retropubic prostatectomy. Detectable PSA 18 months post surgery. Salvage radiation 2003. PSA has continued to rise almost continuously to current level – 197.8.
Cost of Xtandi (
enzalutamide
) Diagnosed in 2000 at age 61. PSA 5.6. Radical retropubic prostatectomy. Detectable PSA 18 months post surgery. Salvage radiation 2003. PSA has continued to rise almost continuously to current level – 197.8.
Davisjl
in
Advanced Prostate Cancer
9 years ago
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