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Enzalutamide
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New AR-V7 Test. German; simpler; cheaper(?).
Moreover, it can also determine whether or not the tumor is resistant to treatment with abiraterone and
enzalutamide
.
Moreover, it can also determine whether or not the tumor is resistant to treatment with abiraterone and
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Olaparib & Durvalumab ... ASCO 2017
All were treated with
enzalutamide
(35%), abiraterone (6%) or both (59%). Most were ECOG status 0-1. 63% had bony and visceral metastatic disease.
All were treated with
enzalutamide
(35%), abiraterone (6%) or both (59%). Most were ECOG status 0-1. 63% had bony and visceral metastatic disease.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Enzalutamide
Please tell me what you know about
Enzalutamide
without copy+pasting from a website. I am so scared for my dad as he just found out his prostate cancer has now metastasized to his bones. What are your personal experiences and what should I expect from here on out?
Please tell me what you know about
Enzalutamide
without copy+pasting from a website. I am so scared for my dad as he just found out his prostate cancer has now metastasized to his bones. What are your personal experiences and what should I expect from here on out?
stephaniejRN
in
Fight Prostate Cancer
7 years ago
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AR-V7 Tests - Video
So, the usefulness of the test really becomes important after abiraterone or
enzalutamide
particularly. The second AR-V7 test, which was developed at Johns Hopkins by Dr. Luo’s lab, is an RNA-based expression.
So, the usefulness of the test really becomes important after abiraterone or
enzalutamide
particularly. The second AR-V7 test, which was developed at Johns Hopkins by Dr. Luo’s lab, is an RNA-based expression.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Metformin and Valproic Acid
The role of the androgen receptor (AR) was investigated using the AR antagonist,
Enzalutamide
. The combination of MET and VPA synergistically inhibited proliferation in LNCaP and PC-3, with no significant effect in PrEC.
The role of the androgen receptor (AR) was investigated using the AR antagonist,
Enzalutamide
. The combination of MET and VPA synergistically inhibited proliferation in LNCaP and PC-3, with no significant effect in PrEC.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Emotional support needed!
He will be starting
Enzalutamide
in a few weeks. Needless to say I am feeling so many emotions including anger and sadness. I don't want my Dad to die. I'm 28 years old and not sure what I'm going to do without him!
He will be starting
Enzalutamide
in a few weeks. Needless to say I am feeling so many emotions including anger and sadness. I don't want my Dad to die. I'm 28 years old and not sure what I'm going to do without him!
stephaniejRN
in
Advanced Prostate Cancer
7 years ago
Quercetin & AR-V7.
The suppression of AR-V7 by quercetin resensitizes
enzalutamide
-resistant prostate cancer cells to treatment with
enzalutamide
.
The suppression of AR-V7 by quercetin resensitizes
enzalutamide
-resistant prostate cancer cells to treatment with
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Zytiga + Statins in CRPC
CONCLUSIONS: Contrary to our initial hypothesis, there was a trend toward longer (rather than shorter) AA duration in statin users in the entire DFCI cohort and in the
enzalutamide
- and docetaxel-naïve JHU patients.
CONCLUSIONS: Contrary to our initial hypothesis, there was a trend toward longer (rather than shorter) AA duration in statin users in the entire DFCI cohort and in the
enzalutamide
- and docetaxel-naïve JHU patients.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
PREVAIL Trial [Xtandi] - low-PSA cases
Post-hoc analyses included radiographic progression-free survival and overall survival in the once-daily
enzalutamide
and placebo arms.
Post-hoc analyses included radiographic progression-free survival and overall survival in the once-daily
enzalutamide
and placebo arms.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Another promising androgen blocker in clinical trials: Darolutamide (ODM-201)
Here's a quote from an article: "One advantage is that darolutamide has been found to block the activity of all tested/well-known mutant ARs in prostate cancer, including the recently identified clinically-relevant F876L mutation that produces resistance to
enzalutamide
and apalutamide.
Here's a quote from an article: "One advantage is that darolutamide has been found to block the activity of all tested/well-known mutant ARs in prostate cancer, including the recently identified clinically-relevant F876L mutation that produces resistance to
enzalutamide
and apalutamide.
Hidden
in
Advanced Prostate Cancer
7 years ago
free Testosterone [fT] & survival.
"A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel, abiraterone acetate,
enzalutamide
, cabozantinib, carboplatin or cabazitaxel."
"A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel, abiraterone acetate,
enzalutamide
, cabozantinib, carboplatin or cabazitaxel."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Quercitin: The Media is the Message!
After reading the previous referrence to “Quercetin targets hnRNPA1 to overcome
enzalutamide
resistance in prostate cancer cells” cited by one of our members, I decided to read the entire paper.
After reading the previous referrence to “Quercetin targets hnRNPA1 to overcome
enzalutamide
resistance in prostate cancer cells” cited by one of our members, I decided to read the entire paper.
Kuanyin
in
Advanced Prostate Cancer
7 years ago
Ranolazine + Xtandi
This results in increased androgen receptor (AR) action and increased sensitivity to the anti-androgen
enzalutamide
.
This results in increased androgen receptor (AR) action and increased sensitivity to the anti-androgen
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
CRPC & Prednisolone or Dexamethasone. Neutrophil to Lymphocyte Ratio [NLR].
A 2015 paper [2] details a Phase II study "among chemotherapy naïve CRPC patients who had not received prior abiraterone or
enzalutamide
therapy."
A 2015 paper [2] details a Phase II study "among chemotherapy naïve CRPC patients who had not received prior abiraterone or
enzalutamide
therapy."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Keytruda
Patients with evidence of progression on
enzalutamide
were treated with pembrolizumab 200 mg IV every 3 weeks for 4 doses; pembrolizumab was added to standard dose
enzalutamide
.
Patients with evidence of progression on
enzalutamide
were treated with pembrolizumab 200 mg IV every 3 weeks for 4 doses; pembrolizumab was added to standard dose
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Lupron side effects
I'm having a great deal of problem with the side effects of the Lupron (and the
enzalutamide
). Besides the heat flashes, I'm completely emotionally overwhelmed, sometimes over something, sometimes over nothing. And a complete lack of motivation.
I'm having a great deal of problem with the side effects of the Lupron (and the
enzalutamide
). Besides the heat flashes, I'm completely emotionally overwhelmed, sometimes over something, sometimes over nothing. And a complete lack of motivation.
Joelhirsch
in
Advanced Prostate Cancer
7 years ago
Resveratrol & ARV7
Since it lacks the ligand binding domain but retains the intact DNA binding domain, ARV7 is constitutively active, which makes ARV7-positive prostate cancer responsive to neither abiraterone nor
enzalutamide
.
Since it lacks the ligand binding domain but retains the intact DNA binding domain, ARV7 is constitutively active, which makes ARV7-positive prostate cancer responsive to neither abiraterone nor
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
New Here - first post
study involves
enzalutamide
and two immunotherapies. I hate all of this. Not sure if I'm going to continue to treat or not. The treatment side effects are brutal.
study involves
enzalutamide
and two immunotherapies. I hate all of this. Not sure if I'm going to continue to treat or not. The treatment side effects are brutal.
Joelhirsch
in
Advanced Prostate Cancer
7 years ago
repost marijuana drug interaction article
Carbamazepine,
enzalutamide
, fosphenytoin, phenobarbital, phenytoin, primidone, rifabutin, rifampin, rifapentine, St. John's wort. Strong 3A4 inhibitors.
Carbamazepine,
enzalutamide
, fosphenytoin, phenobarbital, phenytoin, primidone, rifabutin, rifampin, rifapentine, St. John's wort. Strong 3A4 inhibitors.
erash
in
My MSAA Community
7 years ago
Melatonin & AR-V7
Given that constitutively active androgen receptor splice variants, in particular AR-V7, have been shown to confer resistance to abiraterone or
enzalutamide
, and that activation of NF-κB and reactivation of AR signaling are involved in prostate cancer progression and CRPC development, it would be of
Given that constitutively active androgen receptor splice variants, in particular AR-V7, have been shown to confer resistance to abiraterone or
enzalutamide
, and that activation of NF-κB and reactivation of AR signaling are involved in prostate cancer progression and CRPC development, it would be of
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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