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Enzalutamide
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Olaparib/Durvalumab Combo Shows Promise in mCRPC
“But emerging data suggest potential activity in combinations, as seen with results reported with
enzalutamide
(Xtandi) plus pembrolizumab (Keytruda) and with a DNA-based vaccine plus pembrolizumab.”
“But emerging data suggest potential activity in combinations, as seen with results reported with
enzalutamide
(Xtandi) plus pembrolizumab (Keytruda) and with a DNA-based vaccine plus pembrolizumab.”
JLS1
in
Advanced Prostate Cancer
7 years ago
Quality of Life in Second-Line Treatment of Metastatic Castration-Resistant Prostate
At the time of study,
Enzalutamide
was not yet licensed in Switzerland so not included. It's a very interesting article so thought I would share it. http://www.clinical-genitourinary-cancer.com/article/S1558-7673(17)30244-6/pdf
At the time of study,
Enzalutamide
was not yet licensed in Switzerland so not included. It's a very interesting article so thought I would share it. http://www.clinical-genitourinary-cancer.com/article/S1558-7673(17)30244-6/pdf
Hidden
in
Advanced Prostate Cancer
7 years ago
Is AR-V7 Testing Pointless?
Neither abiraterone nor
enzalutamide
can have therapeutic activity against AR-V7 cells.
Neither abiraterone nor
enzalutamide
can have therapeutic activity against AR-V7 cells.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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No longer prostate cancer
This explains why I failed to get benefit from Provenge or
Enzalutamide
. The rapid change occurred since August when a PET scan showed the growth of tumors in my mediastinum and left pleural space. They have now become very aggressive and are producing fluid rapidly.
This explains why I failed to get benefit from Provenge or
Enzalutamide
. The rapid change occurred since August when a PET scan showed the growth of tumors in my mediastinum and left pleural space. They have now become very aggressive and are producing fluid rapidly.
DenDoc
in
Advanced Prostate Cancer
7 years ago
Ralaniten [EPI-506]
mentions Ralaniten (aka EPI-506) as a: "novel first-in-class drug ... which binds to a unique region in the N-terminus domain of both the full-length and the truncated constitutively active splice variants of the AR, {&} is currently in clinical trials for patients who previously received abiraterone,
enzalutamide
mentions Ralaniten (aka EPI-506) as a: "novel first-in-class drug ... which binds to a unique region in the N-terminus domain of both the full-length and the truncated constitutively active splice variants of the AR, {&} is currently in clinical trials for patients who previously received abiraterone,
enzalutamide
pjoshea13
in
Advanced Prostate Cancer
7 years ago
ASCO Genitourinary Cancers Symposium (Phase II study of enzalutamide monotherapy with radiation therapy for intermediate risk PCa)
Testosterone and free testosterone levels rose significantly on
enzalutamide
therapy. Conclusions:
Enzalutamide
monotherapy with RT may be as effective as castrating ADT, and associated with fewer side effects.
Testosterone and free testosterone levels rose significantly on
enzalutamide
therapy. Conclusions:
Enzalutamide
monotherapy with RT may be as effective as castrating ADT, and associated with fewer side effects.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Finally, Real Promise' for Prostate Cancers With No Therapy20+-Month Improvement in Metastasis-Free Survival
In the PROSPER study, eligible men were also randomly assigned in a 2:1 ratio to receive either
enzalutamide
160 mg or placebo.
In the PROSPER study, eligible men were also randomly assigned in a 2:1 ratio to receive either
enzalutamide
160 mg or placebo.
Hidden
in
Advanced Prostate Cancer
7 years ago
Recent article about Lutetium 177 treatment in advanced mCRPC by doctors at the Technical University of Munich
Eligibility criteria for 177Lu-PSMA-I&T therapy included previous treatment with abiraterone or
enzalutamide
, previous taxane-based chemotherapy or unsuitability for taxanes as well as positive 68Ga-PSMA tracer uptake of metastases in a prior PET-scan.
Eligibility criteria for 177Lu-PSMA-I&T therapy included previous treatment with abiraterone or
enzalutamide
, previous taxane-based chemotherapy or unsuitability for taxanes as well as positive 68Ga-PSMA tracer uptake of metastases in a prior PET-scan.
Hidden
in
Advanced Prostate Cancer
7 years ago
Apalutamide - SPARTAN versus Enzalutamide - PROSPER.
term=
Enzalutamide
+PROSPER&rank=1 [4] https://www.clinicaltrials.gov/ct2/show/NCT01946204?term=Apalutamide+SPARTAN&rank=1
term=
Enzalutamide
+PROSPER&rank=1 [4] https://www.clinicaltrials.gov/ct2/show/NCT01946204?term=Apalutamide+SPARTAN&rank=1
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Interesting result for BRCA patients from ASCO2018
"Effect of germline DNA repair gene mutations on outcomes in men with metastatic castration-resistant prostate cancer receiving first-line abiraterone and
enzalutamide
."
"Effect of germline DNA repair gene mutations on outcomes in men with metastatic castration-resistant prostate cancer receiving first-line abiraterone and
enzalutamide
."
snoraste
in
Advanced Prostate Cancer
7 years ago
New Memberas
Currently on
Enzalutamide
with fingers crossed!
Currently on
Enzalutamide
with fingers crossed!
PeturB
in
Advanced Prostate Cancer
7 years ago
Advanced metastatic protate cancer but still hoping.
Plus daily intake of
enzalutamide
. I have been on other medications but they have failed my PSA started to rise and then I've tried a new drug which put it back down again at the moment
enzalutamide
appears to be the best one so far for me.
Plus daily intake of
enzalutamide
. I have been on other medications but they have failed my PSA started to rise and then I've tried a new drug which put it back down again at the moment
enzalutamide
appears to be the best one so far for me.
GarawayGhd
in
Advanced Prostate Cancer
7 years ago
Is anyone else on the Enzalutamide and LY3023414 clinical trial?
My husband has been on the xtandi phase 2 trial a short time and his PSA is dropping. It went from 21 to 3 in ten days. So far, so good. The fatigue and bone pain have increased. It is not stopping my husband though. I am looking to compare notes with someone else on the trial Thank you to all the
My husband has been on the xtandi phase 2 trial a short time and his PSA is dropping. It went from 21 to 3 in ten days. So far, so good. The fatigue and bone pain have increased. It is not stopping my husband though. I am looking to compare notes with someone else on the trial Thank you to all the
StephjoeSteph4197
in
Advanced Prostate Cancer
7 years ago
ASCO Genitourinary Cancers Symposium [PROSPER].
Abstract: https://gucasym.org/sites/gucasym.org/files/GU18-Prostate-Cancer-Localized-Disease.pdf -Patrick 3 Oral Abstract Session, Thu, 1:00 PM-2:30 PM and Poster Session (Board #A4), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM PROSPER: A phase 3, randomized, double-blind, placebo (PBO)-controlled study of
enzalutamide
Abstract: https://gucasym.org/sites/gucasym.org/files/GU18-Prostate-Cancer-Localized-Disease.pdf -Patrick 3 Oral Abstract Session, Thu, 1:00 PM-2:30 PM and Poster Session (Board #A4), Thu, 11:30 AM-1:00 PM and 5:15 PM-6:15 PM PROSPER: A phase 3, randomized, double-blind, placebo (PBO)-controlled study of
enzalutamide
pjoshea13
in
Advanced Prostate Cancer
7 years ago
ASCO Genitourinary Cancers Symposium (Olaparib and Durvalumab in metastatic castrate-resistant prostate cancer (mCRPC))
Prior treatment with
enzalutamide
and/or abiraterone is required. D is given at 1500 mg iv q28 days + O 300 mg tablets po q12 hours. The primary endpoint is PFS. Core biopsies undergo mutational analysis.
Prior treatment with
enzalutamide
and/or abiraterone is required. D is given at 1500 mg iv q28 days + O 300 mg tablets po q12 hours. The primary endpoint is PFS. Core biopsies undergo mutational analysis.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Bipolar Androgen Therapy in Men With Metastatic Castration-Resistant Prostate Cancer After Progression on Enzalutamide
http://www.practiceupdate.com/content/bipolar-androgen-therapy-in-men-with-metastatic-castration-resistant-prostate-cancer-after-progression-on-
enzalutamide
/62093/61/11/1
http://www.practiceupdate.com/content/bipolar-androgen-therapy-in-men-with-metastatic-castration-resistant-prostate-cancer-after-progression-on-
enzalutamide
/62093/61/11/1
snoraste
in
Advanced Prostate Cancer
7 years ago
AR-V7, Zytiga(abiraterone) and Xtandi (enzalutamide)
According so some studies, 40-50 percent of patients receiving any of the above drugs do not respond well or develop resistance in about one year. I am curious to know if any of you who are already taken these drugs know whether you have been genetically screened for the presence or absence of AR-V7
According so some studies, 40-50 percent of patients receiving any of the above drugs do not respond well or develop resistance in about one year. I am curious to know if any of you who are already taken these drugs know whether you have been genetically screened for the presence or absence of AR-V7
Cmdrdata
in
Advanced Prostate Cancer
7 years ago
Metformin reverses prostate cancer resistance to enzalutamide?
Judge for yourself.. https://www.ncbi.nlm.nih.gov/pubmed/28837141 Of course what do I know?
Judge for yourself.. https://www.ncbi.nlm.nih.gov/pubmed/28837141 Of course what do I know?
Hidden
in
Advanced Prostate Cancer
7 years ago
"Role of PARP Inhibitors Clarified in Prostate Cancer"
If these DNA repair alterations are present after treatment with abiraterone, docetaxel, or
enzalutamide
, there is a higher response rate to olaparib.
If these DNA repair alterations are present after treatment with abiraterone, docetaxel, or
enzalutamide
, there is a higher response rate to olaparib.
JLS1
in
Advanced Prostate Cancer
7 years ago
FDA Grants Priority Review to Apalutamide ...
Apalutamide may be the successor to
Enzalutamide
[Xtandi].
Apalutamide may be the successor to
Enzalutamide
[Xtandi].
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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