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Enzalutamide
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Combination Treatments for Hormone Sensitive PC (mHSPC): Trusting a Meta-Analysis
Enzalutamide
appeared to have better OS compared with docetaxel in men with low-volume disease, but there was no difference in other comparisons.
Enzalutamide
appeared to have better OS compared with docetaxel in men with low-volume disease, but there was no difference in other comparisons.
MateoBeach
in
Advanced Prostate Cancer
3 years ago
CRPC special-- causes of Enzalutamide resistance, Treatment comparisons in nMCRPC, and Improved OS with Masitinib and Docetaxel
We demonstrate an increased number of BRCA2 alterations post-
enzalutamide
highlighting importance of serial tumor sampling in CRPC.
We demonstrate an increased number of BRCA2 alterations post-
enzalutamide
highlighting importance of serial tumor sampling in CRPC.
NPfisherman
in
Fight Prostate Cancer
3 years ago
Akkermansia
demonstrated A. muciniphila to invoke a multiplicity of health benefits in their hosts and improve the efficacy of checkpoint inhibitor cancer immunotherapies" 2] 2018, Johns Hopkins: This study reported that that [u]
oral
[/u] androgen receptor axis-targeted therapies (ATT), including bicalutamide,
enzalutamide
demonstrated A. muciniphila to invoke a multiplicity of health benefits in their hosts and improve the efficacy of checkpoint inhibitor cancer immunotherapies" 2] 2018, Johns Hopkins: This study reported that that [u]
oral
[/u] androgen receptor axis-targeted therapies (ATT), including bicalutamide,
enzalutamide
pjoshea13
in
Advanced Prostate Cancer
3 years ago
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Radiotherapy - are there any disadvantages?
So, 7 months on
enzalutamide
has passed quickly and I get a phone call out of the blue from the Royal Marsden. "We want you to start targeted radiotherapy on your prostate. Please come in for us to arrange this." My PSA currently hovers around 0.18.
So, 7 months on
enzalutamide
has passed quickly and I get a phone call out of the blue from the Royal Marsden. "We want you to start targeted radiotherapy on your prostate. Please come in for us to arrange this." My PSA currently hovers around 0.18.
londoncyclist48
in
Advanced Prostate Cancer
3 years ago
Immunotherapy Clinical Trial or Olaparib (Lynparza)?
But, if he is put into the control group, he'd receive
enzalutamide
(another ADT drug). 2. Olaparib (Lynparza) - I'm not super convinced of the efficacy of this treatment course.
But, if he is put into the control group, he'd receive
enzalutamide
(another ADT drug). 2. Olaparib (Lynparza) - I'm not super convinced of the efficacy of this treatment course.
PCdaughte
in
Advanced Prostate Cancer
3 years ago
Sartor on BAT and genomic profiling (excerpts)
By the way, one of the important findings from the transformer study is that after the use of testosterone, you can re-sensitize to things like
enzalutamide
, and you can come back with the
enzalutamide
and get a very high response rate. And that is a different subset analysis.
By the way, one of the important findings from the transformer study is that after the use of testosterone, you can re-sensitize to things like
enzalutamide
, and you can come back with the
enzalutamide
and get a very high response rate. And that is a different subset analysis.
cigafred
in
Advanced Prostate Cancer
3 years ago
The same mRNA science that brought us the COVID-19 vaccine is being studied for mCRPCa
., abiraterone or
enzalutamide
, docetaxel, cabazitaxel) or cannot tolerate any of these therapies. These lines of therapy include life-prolonging therapies administered in the metastatic hormone-sensitive setting.”
., abiraterone or
enzalutamide
, docetaxel, cabazitaxel) or cannot tolerate any of these therapies. These lines of therapy include life-prolonging therapies administered in the metastatic hormone-sensitive setting.”
tallguy2
in
Advanced Prostate Cancer
3 years ago
Enzalutamide Resistance & Treatment-Emergent AR Changes
We designed a phase 2 multicenter study of
enzalutamide
in metastatic CRPC incorporating tissue and blood biomarkers to dissect mechanisms driving resistance.
We designed a phase 2 multicenter study of
enzalutamide
in metastatic CRPC incorporating tissue and blood biomarkers to dissect mechanisms driving resistance.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
TRANSFORMER [BAT] Presentation.
Worthwhile video, even for those familiar with TRANSFORMER: https://www.urotoday.com/video-lectures/mcrpc-treatment/video/2077-transformer-a-study-comparing-bipolar-androgen-therapy-vs-
enzalutamide
-in-mcrpc-emmanuel-antonarakis.html -Patrick
Worthwhile video, even for those familiar with TRANSFORMER: https://www.urotoday.com/video-lectures/mcrpc-treatment/video/2077-transformer-a-study-comparing-bipolar-androgen-therapy-vs-
enzalutamide
-in-mcrpc-emmanuel-antonarakis.html -Patrick
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Alkaline Phosphate has increased from 106 iu/L to 160 in the space of 4-weeks. Currently on Enzalutamide (Xtandi) and Quarterly Pro Stap
Hello. My PSA appears to have reached it's nadir at 0.07 for the past 4 weeks (nope, I am not James Bond alas) but my Alkaline Phosphate has increased by 66% in the last 4 weeks. Not due to speak to my Oncologist until July. Is this something to be concerned about? Any help or thoughts gratefully received
Hello. My PSA appears to have reached it's nadir at 0.07 for the past 4 weeks (nope, I am not James Bond alas) but my Alkaline Phosphate has increased by 66% in the last 4 weeks. Not due to speak to my Oncologist until July. Is this something to be concerned about? Any help or thoughts gratefully received
lcfcpolo
in
Advanced Prostate Cancer
3 years ago
Cabazitaxel vs Abiraterone or Enzalutamide in Poor-Prognosis Metastatic Castration-Resistant Prostate Cancer
Citation: Annals of Oncology Cabazitaxel Versus Abiraterone or
Enzalutamide
in Poor Prognosis Metastatic Castration-Resistant Prostate Cancer: A Multicentre, Randomised, Open-Label, Phase 2 Trial Ann.
Citation: Annals of Oncology Cabazitaxel Versus Abiraterone or
Enzalutamide
in Poor Prognosis Metastatic Castration-Resistant Prostate Cancer: A Multicentre, Randomised, Open-Label, Phase 2 Trial Ann.
Balsam01
in
Advanced Prostate Cancer
3 years ago
Optimal Chemo-Hormonal Sequencing for MCRPC Maybe Taxotere - Zytiga - Jevtana - Xtandi
The study included two different groups: Group A (80 men) were given docetaxel chemotherapy (Taxotere) followed by one of the second-line hormonal therapies: either abiraterone (Zytiga) or
enzalutamide
(Xtandi) Group B (32 men) were given a second-line hormonal therapy then followed by Taxotere
The study included two different groups: Group A (80 men) were given docetaxel chemotherapy (Taxotere) followed by one of the second-line hormonal therapies: either abiraterone (Zytiga) or
enzalutamide
(Xtandi) Group B (32 men) were given a second-line hormonal therapy then followed by Taxotere
JoelT
in
Fight Prostate Cancer
3 years ago
What next? Abiraterone->Docetaxel->Cabazitaxel-> ?
3.How long cabazitaxel,
Enzalutamide
(Xtandi) generally work in mCRPC setting post-Abiraterone & Docetaxel? 4.Rechallenging Zytiga ?
3.How long cabazitaxel,
Enzalutamide
(Xtandi) generally work in mCRPC setting post-Abiraterone & Docetaxel? 4.Rechallenging Zytiga ?
pka21
in
Advanced Prostate Cancer
4 years ago
A look at the next generation of Androgen Receptor therapies--AR Degraders/PROTACS
A PROTAC causes breakdown of proteins by targeting a specific system (in this case--AR system in PCa cell lines) as opposed to being an androgen production blocker (abiraterone) or an AR binder inhibitor (
enzalutamide
).
A PROTAC causes breakdown of proteins by targeting a specific system (in this case--AR system in PCa cell lines) as opposed to being an androgen production blocker (abiraterone) or an AR binder inhibitor (
enzalutamide
).
NPfisherman
in
Fight Prostate Cancer
3 years ago
Newer Review Article on Testosterone Replacement and BAT out of China
Alternating 3-month cycles of BAT (400 mg intramuscularly on days 1, 29 or 57), followed by 3 months of ADT alone 30% achieved PSA response; 29 patients progressed on BAT, 52% regained PSA response to
enzalutamide
treatment [81] www.drugdiscoverytoday.com 7 Reviews POST SCREEN therapy, resulting in
Alternating 3-month cycles of BAT (400 mg intramuscularly on days 1, 29 or 57), followed by 3 months of ADT alone 30% achieved PSA response; 29 patients progressed on BAT, 52% regained PSA response to
enzalutamide
treatment [81] www.drugdiscoverytoday.com 7 Reviews POST SCREEN therapy, resulting in
MateoBeach
in
Advanced Prostate Cancer
3 years ago
HOW GOOD IS DAROLUTAMIDE?
MO wants old standby,
Enzalutamide
. But I've read highly complimentary stuff about new AR, Darolutamide. Ideal chemical structure; fights receptors in two ways instead of one.
MO wants old standby,
Enzalutamide
. But I've read highly complimentary stuff about new AR, Darolutamide. Ideal chemical structure; fights receptors in two ways instead of one.
yeatz
in
Advanced Prostate Cancer
4 years ago
Bipolar Androgen Therapy vs Enzalutamide in Asymptomatic Men With Castration-Resistant Metastatic Prostate Cancer.
The PFS2 for BAT→
enzalutamide
was 28.2 versus 19.6 months for
enzalutamide
→BAT (HR, 0.44; 95% CI, 0.22 to 0.88; P = .02). OS was 32.9 months for BAT versus 29.0 months for
enzalutamide
(HR, 0.95; 95% CI, 0.66 to 1.39; P = .80).
The PFS2 for BAT→
enzalutamide
was 28.2 versus 19.6 months for
enzalutamide
→BAT (HR, 0.44; 95% CI, 0.22 to 0.88; P = .02). OS was 32.9 months for BAT versus 29.0 months for
enzalutamide
(HR, 0.95; 95% CI, 0.66 to 1.39; P = .80).
Balsam01
in
Advanced Prostate Cancer
4 years ago
Extreme responses to immune checkpoint blockade following bipolar androgen therapy and enzalutamide in patients with mcrp cancer.
“Priming the pump” seems to be worth investigating if you have a DNA repair gene mutation ( BRCA2, ATM etc.) This was highlighted in a previous post but this article includes the NCT trial number which takes it to the next level https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585736/
“Priming the pump” seems to be worth investigating if you have a DNA repair gene mutation ( BRCA2, ATM etc.) This was highlighted in a previous post but this article includes the NCT trial number which takes it to the next level https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585736/
p3d1
in
Advanced Prostate Cancer
3 years ago
TRANSFORMER: A Randomized Phase II Study Comparing Bipolar Androgen Therapy Versus Enzalutamide in Asymptomatic Men With Castration-Resistan
Further study is required to confirm whether sequential therapy with BAT and
enzalutamide
can improve survival in men with CRPC." https://ascopubs.org/doi/full/10.1200/JCO.20.02759
Further study is required to confirm whether sequential therapy with BAT and
enzalutamide
can improve survival in men with CRPC." https://ascopubs.org/doi/full/10.1200/JCO.20.02759
snoraste
in
Advanced Prostate Cancer
4 years ago
1/4 dose enzalutamide for MCRPc working for 4 years in 87 yr. old
ABSTRACT BACKGROUND: The management of metastatic castration-resistant prostate cancer involves second-generation antiandrogen therapy, including
enzalutamide
. The recommended dose of 160mg/day is sometimes difficult to use in elderly patients because of the burden of comorbidities.
ABSTRACT BACKGROUND: The management of metastatic castration-resistant prostate cancer involves second-generation antiandrogen therapy, including
enzalutamide
. The recommended dose of 160mg/day is sometimes difficult to use in elderly patients because of the burden of comorbidities.
George71
in
Advanced Prostate Cancer
4 years ago
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