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A Phase III Trial of Enzalutamide Versus Enzalutamide, Abiraterone and Prednisone for Metastatic Castration Resistant Prostate Cancer.
https://www.urotoday.com/conference-highlights/asco-2019-annual-meeting/asco-2019-prostate-cancer/112895-asco-2019-alliance-a031201-a-phase-iii-trial-of-enzalutamide-versus-enzalutamide-
abiraterone
-and-prednisone-for-metastatic-castration-resistant-prostate-cancer.html?
https://www.urotoday.com/conference-highlights/asco-2019-annual-meeting/asco-2019-prostate-cancer/112895-asco-2019-alliance-a031201-a-phase-iii-trial-of-enzalutamide-versus-enzalutamide-
abiraterone
-and-prednisone-for-metastatic-castration-resistant-prostate-cancer.html?
tango65
in
Advanced Prostate Cancer
5 years ago
ASCO 2019 Abstracts.
Dose finding in combination (CCS1477 +
abiraterone
; CCS1477 + enzalutamide) will be open once monotherapy dose escalation completes.
Dose finding in combination (CCS1477 +
abiraterone
; CCS1477 + enzalutamide) will be open once monotherapy dose escalation completes.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Enzalutamide working for my dad
Once we finally got in for the appointment we discussed the choice between Enzalutamide and
Abiraterone
+ Prednisone and how it is difficult to select which patients are better suited for which drug.
Once we finally got in for the appointment we discussed the choice between Enzalutamide and
Abiraterone
+ Prednisone and how it is difficult to select which patients are better suited for which drug.
fmoser
in
Advanced Prostate Cancer
5 years ago
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Happy Dance Time!
Well after enduring
abiraterone
side effects for a couple weeks today I got my coveted "<" with the lab reporting "< 0.01". Happy Dance Time! In other news: the
abiraterone
side effects appear to be easing off, and this morning I ran three miles faster than my 5K time from last November.
Well after enduring
abiraterone
side effects for a couple weeks today I got my coveted "<" with the lab reporting "< 0.01". Happy Dance Time! In other news: the
abiraterone
side effects appear to be easing off, and this morning I ran three miles faster than my 5K time from last November.
tom67inMA
in
Advanced Prostate Cancer
5 years ago
Skip the injection, go straight to abiraterone
I was discussing
abiraterone
acetate (brand name Zytiga) with my MO and asked why it was always given with ADT. "I don't know, it's just always been done that way." This seemed odd to me.
I was discussing
abiraterone
acetate (brand name Zytiga) with my MO and asked why it was always given with ADT. "I don't know, it's just always been done that way." This seemed odd to me.
FCoffey
in
Advanced Prostate Cancer
5 years ago
Abiraterone Acetate Plus Prednisone in Newly Diagnosed High-Risk Metastatic Castration-Sensitive Prostate Cancer: Final OS Results
Abiraterone
was well tolerated; adverse events leading to treatment discontinuation occurred in 16% of the
abiraterone
group vs 10% in the placebo group. The most common grade 3-4 adverse events were hypertension (21% vs 10%), and hypokalemia (12% vs 2%).
Abiraterone
was well tolerated; adverse events leading to treatment discontinuation occurred in 16% of the
abiraterone
group vs 10% in the placebo group. The most common grade 3-4 adverse events were hypertension (21% vs 10%), and hypokalemia (12% vs 2%).
Balsam01
in
Advanced Prostate Cancer
5 years ago
Don’t like the weather here in Ohio?
Now on 3rd month on
Abiraterone
Acetate and each week brings a new challenge from joint pain, bouts of sadness that go as quickly as they come on, weight fluctuations and a return to almost normal blood pressure to name a few.
Now on 3rd month on
Abiraterone
Acetate and each week brings a new challenge from joint pain, bouts of sadness that go as quickly as they come on, weight fluctuations and a return to almost normal blood pressure to name a few.
3putt
in
Advanced Prostate Cancer
5 years ago
Abiraterone Acetate Plus Prednisone in Newly Diagnosed High-Risk Metastatic Castration-Sensitive Prostate Cancer
Patients were randomly assigned (1:1) to receive
abiraterone
acetate (1000 mg) once daily orally plus prednisone (5 mg) once daily orally and ADT (
abiraterone
acetate plus prednisone group) or matching placebos plus ADT (placebo group); each treatment cycle was 28 days.
Patients were randomly assigned (1:1) to receive
abiraterone
acetate (1000 mg) once daily orally plus prednisone (5 mg) once daily orally and ADT (
abiraterone
acetate plus prednisone group) or matching placebos plus ADT (placebo group); each treatment cycle was 28 days.
Balsam01
in
Advanced Prostate Cancer
5 years ago
LUPRRon OR ZOLADEX
Along with Zytiga (
abiraterone
) I am on 3 monthly injection of Zoladex ( gosarellin). My PSA is undetectable. I have noticed that most people seem to be on 3 monthly injection of Lupron. I’m in Vancouver Canada.
Along with Zytiga (
abiraterone
) I am on 3 monthly injection of Zoladex ( gosarellin). My PSA is undetectable. I have noticed that most people seem to be on 3 monthly injection of Lupron. I’m in Vancouver Canada.
nobaday
in
Advanced Prostate Cancer
5 years ago
LATITUDE - Final report.
Patients were randomly assigned (1:1) to receive
abiraterone
acetate (1000 mg) once daily orally plus prednisone (5 mg) once daily orally and ADT (
abiraterone
acetate plus prednisone group) or matching placebos plus ADT (placebo group); each treatment cycle was 28 days.
Patients were randomly assigned (1:1) to receive
abiraterone
acetate (1000 mg) once daily orally plus prednisone (5 mg) once daily orally and ADT (
abiraterone
acetate plus prednisone group) or matching placebos plus ADT (placebo group); each treatment cycle was 28 days.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Docetaxel - day one
First treatment was
abiraterone
, second was an immunotherapy trial, third was radiotherapy to the Prostate. Today I had a baseline CT scan, PSA currently 50. Treatment went ok, decided to try an icecap, will see how that goes.
First treatment was
abiraterone
, second was an immunotherapy trial, third was radiotherapy to the Prostate. Today I had a baseline CT scan, PSA currently 50. Treatment went ok, decided to try an icecap, will see how that goes.
easeytiger
in
Advanced Prostate Cancer
5 years ago
high dose testosterone and androgen receptors
HDT was given post-median of 2 (1-10) CRPC therapies. 73% (24/33) of pts previously received
abiraterone
(n = 14), enzalutamide (n = 4), or both sequentially (n = 6) prior to HDT for a median of 10.5 months (0.7-56.8).
HDT was given post-median of 2 (1-10) CRPC therapies. 73% (24/33) of pts previously received
abiraterone
(n = 14), enzalutamide (n = 4), or both sequentially (n = 6) prior to HDT for a median of 10.5 months (0.7-56.8).
kaptank
in
Advanced Prostate Cancer
5 years ago
VERU Inc.
The Company plans to conduct an open label Phase 1b/2 clinical trial in men with metastatic castration resistant prostate cancer that have also become resistant to, or who have failed to respond to,
abiraterone
or enzalutamide.
The Company plans to conduct an open label Phase 1b/2 clinical trial in men with metastatic castration resistant prostate cancer that have also become resistant to, or who have failed to respond to,
abiraterone
or enzalutamide.
Magnus1964
in
Advanced Prostate Cancer
5 years ago
Lu-177 "Vision" trial NCT03511664 Protocols
Novel androgen axis drugs [NAADs] (such as
abiraterone
or enzalutamide) are allowed." " COSTS "Lu-PSMA will be provided free of charge in this study to you. The administration of the radionucleotide will be billed to your insurance company.
Novel androgen axis drugs [NAADs] (such as
abiraterone
or enzalutamide) are allowed." " COSTS "Lu-PSMA will be provided free of charge in this study to you. The administration of the radionucleotide will be billed to your insurance company.
Fairwind
in
Advanced Prostate Cancer
5 years ago
Mood Changes on Abiraterone/Prednisone?
Has anybody experienced mood changes on
Abiraterone
/Prednisone? Specifically, have you ever felt a tad manic? I've recently had trouble sleeping despite taking sleep aids.
Has anybody experienced mood changes on
Abiraterone
/Prednisone? Specifically, have you ever felt a tad manic? I've recently had trouble sleeping despite taking sleep aids.
tom67inMA
in
Advanced Prostate Cancer
5 years ago
Enzalutamide (Xtandi) vs Abiraterone (Zytiga) for mHSPCA
Good trial results for both of these for mHSPCa, combined with ADT. Anyone here know the pros/cons? Which has better pfs and os? Thanks. Randall
Good trial results for both of these for mHSPCa, combined with ADT. Anyone here know the pros/cons? Which has better pfs and os? Thanks. Randall
6357axbz
in
Advanced Prostate Cancer
5 years ago
With Lu-177, quit Eligard & Abitaterone ??
I have been asked by the MO handling my Lu-177 treatment to completely stop
Abiraterone
as long as I am taking infusions of Lu-177. He has also told me to discontinue Eligard again till my Lu-177 treatment was over.
I have been asked by the MO handling my Lu-177 treatment to completely stop
Abiraterone
as long as I am taking infusions of Lu-177. He has also told me to discontinue Eligard again till my Lu-177 treatment was over.
whatsinaname
in
Advanced Prostate Cancer
5 years ago
Germline Testing for Men With Prostate Cancer
and enzalutamide, with a subsequent study reporting improved cause-specific and progression-free survival among men with mCRPC and BRCA2 mutations treated with first-line
abiraterone
or enzalutamide over taxanes.9,10 Indeed, mutations in multiple genes (BRCA2, BRCA1, ATM, CHEK2, PALB2, RAD51D, NBN,
and enzalutamide, with a subsequent study reporting improved cause-specific and progression-free survival among men with mCRPC and BRCA2 mutations treated with first-line
abiraterone
or enzalutamide over taxanes.9,10 Indeed, mutations in multiple genes (BRCA2, BRCA1, ATM, CHEK2, PALB2, RAD51D, NBN,
Balsam01
in
Advanced Prostate Cancer
5 years ago
Participation in Trial ADT+SRT
ADT for 6 months consisting of Lupron + Zytiga (
Abiraterone
) w Prednazone + Etealda (Apalutamide). SRT starts in 6 weeks. While I’m hopeful this aggressive treatment will successful, I’m concerned about the side effects by this combo of treatment. The literature is scary.
ADT for 6 months consisting of Lupron + Zytiga (
Abiraterone
) w Prednazone + Etealda (Apalutamide). SRT starts in 6 weeks. While I’m hopeful this aggressive treatment will successful, I’m concerned about the side effects by this combo of treatment. The literature is scary.
Mikeski
in
Advanced Prostate Cancer
5 years ago
LATITUDE Study - final survival analysis
Patients were randomly assigned (1:1) to receive
abiraterone
acetate (1000 mg) once daily orally plus prednisone (5 mg) once daily orally and ADT (
abiraterone
acetate plus prednisone group) or matching placebos plus ADT (placebo group); each treatment cycle was 28 days.
Patients were randomly assigned (1:1) to receive
abiraterone
acetate (1000 mg) once daily orally plus prednisone (5 mg) once daily orally and ADT (
abiraterone
acetate plus prednisone group) or matching placebos plus ADT (placebo group); each treatment cycle was 28 days.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
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