Has anyone with SS tried methotrexate for joint pain and stiffness? If so, how long did it take to work.

[erinstiver]

[Shell567 Administrator Sweet's Syndrome UK]

Hi erinstiver,

Methotrexate is an uncommon treatment for SS, so there isn't that much mention of it in the medical literature. I'll leave a message on the Sweet's Syndrome UK FB group to see if anyone has been given it. facebook.com/groups/sweetss...

[Shell567 Administrator Sweet's Syndrome UK]

Here's some general info about methotrexate including how long it takes to work in people with arthritis (3-12 weeks): arthritisresearchuk.org/art...

[burlp1401]

I have taken MTX since 2001 for Sweet's Syndrome both to calm down the immune system and for the joint pain and stiffness. I can honestly recommend it to anyone. My dose is 10mg once weekly and monthly bloods. I have suffered no skin lesions since I started it. It was recommended to me by Professor Peter von den Driesch in Stuttart although I live in England. Fortunately my team at Southmead Hospital in Bristol decided to go with the MTX rather than cyclosporin. I also have a brilliant dermatologist at Taunton Hospital calle Dr Pryce who first diagnosed me in 1999. I am surprised that more people with Sweet's are not prescribed MTX rather than steroids which I believe do far more long-term harm (just my opinion). Am quite willing to talk to anyone about my condition if it helps.

[erinstiver in reply to burlp1401]

I'm hoping the MTX works. They are weaning me off of the prednisone while they up my MTX.

[erinstiver]

Thanks for the replies!