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Sipuleucel-T
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Moving on to Provenge/Sipuleucel-t
We met with my husband's onc yesterday to discuss the next move since the 3 years of Abiraraterone/prednisone has run its course. His psa numbers are now around 2.0 (up from a low of .04) and psma scan indicates that bone met volume is quite low. A recent lab biopsy didn't reveal much... The good doc
We met with my husband's onc yesterday to discuss the next move since the 3 years of Abiraraterone/prednisone has run its course. His psa numbers are now around 2.0 (up from a low of .04) and psma scan indicates that bone met volume is quite low. A recent lab biopsy didn't reveal much... The good doc
Lavender22
in
Advanced Prostate Cancer
8 days ago
What first?: Provenge or Nubeqa?
docetaxel some months after
sipuleucel
-
T
.
docetaxel some months after
sipuleucel
-
T
.
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
A critical review of Provenge. Your inputs welcomed?
The manufacturing process and proposed mechanism for
sipuleucel
-
T
(3). A) The manufacturing process for
sipuleucel
-
T
is depicted.
The manufacturing process and proposed mechanism for
sipuleucel
-
T
(3). A) The manufacturing process for
sipuleucel
-
T
is depicted.
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
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A List for Newly Diagnosed that My Wife did in 2022 please add to list if anything is missed or wrong or needs updating. TIA
Found online ie: Amazon *Bisphonsphanates, a group of drugs to reduce the risk of a Skeletal Related Event ; they act to bring calcium levels down, Densonumb another option to reduce the risk of SREs * The use of Vaccines such as an Apeceden vaccine and *Immunotherapies such as Provenge (
Sipuleucel
-
T
Found online ie: Amazon *Bisphonsphanates, a group of drugs to reduce the risk of a Skeletal Related Event ; they act to bring calcium levels down, Densonumb another option to reduce the risk of SREs * The use of Vaccines such as an Apeceden vaccine and *Immunotherapies such as Provenge (
Sipuleucel
-
T
Shorehousejam
in
Advanced Prostate Cancer
6 months ago
CAR T-Cell Use Possible in Metastatic Castration-Resistant Prostate Cancer
Then, we have chemotherapy and radioactive particles, and there is immunotherapy
sipuleucel
-
T
. But there’s nothing yet that creates durable remissions. And so, the hope is that T-cell technology is where we might start to achieve that.
Then, we have chemotherapy and radioactive particles, and there is immunotherapy
sipuleucel
-
T
. But there’s nothing yet that creates durable remissions. And so, the hope is that T-cell technology is where we might start to achieve that.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Androgen Receptor [AR] Axis Therapies
Sipuleucel
-
T
immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411-422. de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 2011;364:1995-2005. Scher HI, Fizazi K, Saad F, et al.
Sipuleucel
-
T
immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411-422. de Bono JS, Logothetis CJ, Molina A, et al. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med. 2011;364:1995-2005. Scher HI, Fizazi K, Saad F, et al.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
30 months with PCA - experiences with ADT, Docetaxel, Xtandi / Nubeqa, Provenge and experimental immunotherapy trial.
Among those included adjuvant radiation therapy (we lobbied and convinced a radiologist to go along with this) and Provenge (
sipuleucel
-
T
) as yet another immunotherapy option.
Among those included adjuvant radiation therapy (we lobbied and convinced a radiologist to go along with this) and Provenge (
sipuleucel
-
T
) as yet another immunotherapy option.
Namork
in
Advanced Prostate Cancer
2 years ago
Androgen Receptor Signalling Inhibitors – Post-Chemotherapy, Pre-Chemotherapy and now in castration sensitive prostate cancer - ERC -6.15.21
Palvimo and Ville Paakinaho https://erc.bioscientifica.com/view/journals/erc/aop/erc-21-0038/erc-21-0038.xml
[i]Using immunotherapy in prostate cancer patients: more than
-
T
[/i] - Author(s): Jamie Tae Wook Kwon, Richard J Bryant, and Eileen E Parkes https://erc.bioscientifica.com/view
Palvimo and Ville Paakinaho https://erc.bioscientifica.com/view/journals/erc/aop/erc-21-0038/erc-21-0038.xml
[i]Using immunotherapy in prostate cancer patients: more than
-
T
[/i] - Author(s): Jamie Tae Wook Kwon, Richard J Bryant, and Eileen E Parkes https://erc.bioscientifica.com/view
cujoe
in
Fight Prostate Cancer
3 years ago
Sipuleucel-T boosts survival versus abiraterone or enzalutamide alone in real-world mCRPC analysis
The median OS was improved by 14.5 months with
sipuleucel
-
T
https://www.urologytimes.com/view/
sipuleucel
-
t
-boosts-survival-versus-abiraterone-or-enzalutamide-alone-in-real-world-mcrpc-analysis
The median OS was improved by 14.5 months with
sipuleucel
-
T
https://www.urologytimes.com/view/
sipuleucel
-
t
-boosts-survival-versus-abiraterone-or-enzalutamide-alone-in-real-world-mcrpc-analysis
George71
in
Advanced Prostate Cancer
4 years ago
Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
Additional treatments for metastatic CRPC include taxane-based chemotherapeutic agents (docetaxel, cabazitaxel), cancer immunotherapy (
sipuleucel
-
T
) and the radiopharmaceutical radium Ra-223 dichloride (Table 2).
Additional treatments for metastatic CRPC include taxane-based chemotherapeutic agents (docetaxel, cabazitaxel), cancer immunotherapy (
sipuleucel
-
T
) and the radiopharmaceutical radium Ra-223 dichloride (Table 2).
pjoshea13
in
Advanced Prostate Cancer
3 years ago
What Tx options after resistance to Xtandi?
Im thinking provenge (
sipuleucel
-
t
) or one of the PARP inhibitors (if BRCA+) as alternatives before chemo, but seems they re indicated after having tried chemo, my understanding is that this order maybe due to high cost and not nevessarily patient outcome, so maybe if cost wasnt an issue is it worth
Im thinking provenge (
sipuleucel
-
t
) or one of the PARP inhibitors (if BRCA+) as alternatives before chemo, but seems they re indicated after having tried chemo, my understanding is that this order maybe due to high cost and not nevessarily patient outcome, so maybe if cost wasnt an issue is it worth
Tokyoite
in
Advanced Prostate Cancer
4 years ago
Synergy between radiation of metastases and immunotherapy confirmed
In a short-term phase 2 trial, Xofigo (radium 223 chloride) was combined with Provenge (
sipuleucel
-
T
) in castration-resistant patients.
In a short-term phase 2 trial, Xofigo (radium 223 chloride) was combined with Provenge (
sipuleucel
-
T
) in castration-resistant patients.
Tall_Allen
in
Advanced Prostate Cancer
4 years ago
Exceptional Response to Pembrolizumab in a Patient With Castration-Resistant Prostate Cancer With Pancytopenia From Myelophthisis: A Case Re
Food and Drug Administration approval of the cell-based cancer immunotherapy
sipuleucel
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T
in patients with asymptomatic CRPC with nonvisceral metastases, all other randomized trials of immunotherapy have been negative to date, and prostate cancer is believed to be a relatively immunologically "silent
Food and Drug Administration approval of the cell-based cancer immunotherapy
sipuleucel
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T
in patients with asymptomatic CRPC with nonvisceral metastases, all other randomized trials of immunotherapy have been negative to date, and prostate cancer is believed to be a relatively immunologically "silent
JLS1
in
Advanced Prostate Cancer
4 years ago
CAR-T Cell Therapy
While only one type of immunotherapy,
Sipuleucel
-
T
, has yielded only modest improvements in survival most other types such as viruses, PD-1 and PD-L1 inhibitors, etc. have not been very effective, because of PCa's comparatively low mutational loads, I still have hope that immunotherapy will one day be
While only one type of immunotherapy,
Sipuleucel
-
T
, has yielded only modest improvements in survival most other types such as viruses, PD-1 and PD-L1 inhibitors, etc. have not been very effective, because of PCa's comparatively low mutational loads, I still have hope that immunotherapy will one day be
PhilipSZacarias
in
Advanced Prostate Cancer
4 years ago
Radium-223 in Clinical Practice. Video
Additional phase II and III studies incorporating radium-223 are ongoing, and are designed to evaluate combinations with enzalutamide,
sipuleucel
-
T
, and other approved and experimental agents (ClinicalTrials.gov: NCT02346526, NCT02463799, NCT02225704, NCT01929655, NCT02194842).
Additional phase II and III studies incorporating radium-223 are ongoing, and are designed to evaluate combinations with enzalutamide,
sipuleucel
-
T
, and other approved and experimental agents (ClinicalTrials.gov: NCT02346526, NCT02463799, NCT02225704, NCT01929655, NCT02194842).
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resist
The phase III IMPACT trial randomized men with metastatic CRPC 2:1 to receive
sipuleucel
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T
or placebo and found no significant difference in time to progression, but found an improved median overall survival in the
sipuleucel
-
T
group compared with the placebo group (25.8 months vs 21.7 months).[11] Survival
The phase III IMPACT trial randomized men with metastatic CRPC 2:1 to receive
sipuleucel
-
T
or placebo and found no significant difference in time to progression, but found an improved median overall survival in the
sipuleucel
-
T
group compared with the placebo group (25.8 months vs 21.7 months).[11] Survival
JLS1
in
Advanced Prostate Cancer
5 years ago
CANCER VACCINE
She mentioned that UCSF is doing a clinical trial for a cancer vaccine I think called
Sipuleucel
-
T
. This vaccine is for all cancers. She referred us to UCSF so are waiting to see if he is accepted. Question: Is anyone familiar with this trial? Thanks in advance! BOOGEE
She mentioned that UCSF is doing a clinical trial for a cancer vaccine I think called
Sipuleucel
-
T
. This vaccine is for all cancers. She referred us to UCSF so are waiting to see if he is accepted. Question: Is anyone familiar with this trial? Thanks in advance! BOOGEE
ROLNCIN1
in
Advanced Prostate Cancer
5 years ago
Ra-223 Treatment for Bone Metastases in Castrate-Resistant Prostate Cancer
These include combining Ra-223 with
sipuleucel
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T
or immunooncology agents, to enhance immune responses, and trials in mildly symptomatic or asymptomatic patients. To date, the optimal timing, sequence, and combinations of Ra-223 with other agents are yet to be determined.
These include combining Ra-223 with
sipuleucel
-
T
or immunooncology agents, to enhance immune responses, and trials in mildly symptomatic or asymptomatic patients. To date, the optimal timing, sequence, and combinations of Ra-223 with other agents are yet to be determined.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Emerging cell cycle inhibitors for treating metastatic castration-resistant prostate cancer.
Therapy for metastatic CRPC includes abiraterone acetate, enzalutamide, docetaxel, cabazitaxel,
sipuleucel
-
T
, and radium-223. However, survival remains modest for men with progressive disease despite AR-targeted therapy and docetaxel, and therefore novel treatments are needed.
Therapy for metastatic CRPC includes abiraterone acetate, enzalutamide, docetaxel, cabazitaxel,
sipuleucel
-
T
, and radium-223. However, survival remains modest for men with progressive disease despite AR-targeted therapy and docetaxel, and therefore novel treatments are needed.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Metastasis-Free Survival in Prostate Cancer: Faster Drug Approvals, Better Drugs?
Since then, the FDA has approved four other agents (enzalutamide, cabazitaxel, radium-223, and
sipuleucel
-
T
) on the basis of an OS benefit in metastatic prostate cancer. Promising data also exist for other investigational agents in progressive metastatic CRPC.
Since then, the FDA has approved four other agents (enzalutamide, cabazitaxel, radium-223, and
sipuleucel
-
T
) on the basis of an OS benefit in metastatic prostate cancer. Promising data also exist for other investigational agents in progressive metastatic CRPC.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
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