I have suffered with RLS since 1997. I was seen for what the doctor thought was MS, but came back neg at the time. He put me on Gabapentin. It has been increased, and I have been on it ever since. But also told RLS can be linked to Proteins in the Brain. SO. later, MRI again and told possible MS. My legs have nerve damage and pain can get unbearable. In 2015, I was sent to a Hematologist and they sent blood to a Genetic Ambry Lab, out of State. It took 6 weeks to get back. The doctor told me I had 2 Tumor gene Mutations for Pancreatic and Breast Cancer. It all started with my "legs", yet ended up with having a bad DVT/PE also in 2011. Do your Research, and see what can be related to this. My mother has a horrible time with her legs as well. She spent countless nights with pain and aching. She died of Pancreatic Cancer also. Just saying...... Make sure you are treated with something that will help your legs to relax at night. There has been a lot of Research done now, more than it use to be.