Gleason 3+4/4+3 doesn't always stack up

[pd63]

Case 1- 10 cores, 6 pattern 3, 4 with patter 4 so 3+4Case2- 6 cores, 4 pattern 4, 2 pattern 3, so 4+3

Assuming % in cores is same both cases have same amount of 4.

Am I misunderstanding the above?

[ToolBeltZia]

Not sure I am following.....the Gleason is based on the highest two patterns within each core, not the sum or percentage of patterns taken as an aggregate.

[Tall_Allen]

You are misunderstanding. Your Gleason score is the core with the highest Gleason score. A core is GS 3+4 if less than 50% of that core is pattern 4; GS 4+3 if more than 50% (and the rest of it is pattern 3).

[Teacherdude72]

Treatments are based on the highest Gleason, total of bit numbers. 3+4 is not the same as 4+3. The first number relates to the differentation from normal. 4 is a bit worse than 3. The second number is the less prevalent of the PCA cells and while 4. Is worse the 3 being the second number just shows some are there