I have just been diagnosed with PMR and feeling so depressed with it all at present. From running marathons to being unable to climb stairs, get out of bed in a morning etc. My doctor prescribe 3 pills in a morning but they didn't kick in until day 4 and hardly slept because it all flared up again through the night. I was on holiday unable to visit the doctors so took 2 pills morning and night and felt alot better. My doctor said that was a high dosage but reading some comments about dosage mine was very low. I am at present having more test because the doctor thinks if I have PMR they should have eased the pain faster but everyones body reacts differently.