As you know I am Dr. Costantini's assistant in his HDT research. At various degrees you all have experienced Dr. Costantini's joyful soul and extreme dedication to his work, to provide support and relief to patients and their families.
Since 2011 we have been working every day with reckless dedication, often beyond our own well being. The results we have come to though made up for all the headaches, sleepless nights and the uncountable 80+ working hours weeks we did over the last 8 odd years. The amount of work we built up has become hard to manage, and with the complete lack of support from any member of the scientific community, we had to take it all on ourselves.
Dr. Costantini has worked very hard to help the more patients the possibly, the sooner the possible. But doing so he has neglected his own health.
A few days ago Dr. Costantini had a planned surgical procedure. The procedure per se went well but sadly some post-procedural complications arose. He is currently recovering and I am not in the position to disclose further details on his condition nor concerning the duration of his absence from work.
I am sorry to inform you all that the support you have received to date via emails etc. has to be halted until further notice, until Antonio is back in shape.
I trust you will send your thoughts & prayers his way and I hope for your understanding as I apologize with you all for not being able to ensure that all requests of patients are addressed as timely as it used to be.
Thank you
Best regards
-Marco
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. . . for those who want to support Dr. Costantini's work tangibly, as another way to express gratitude for his selfless service. Like many here, I have been a direct beneficiary of his freely-given guidance, and was dumbfounded by the speed of his responses to my messages. Such dedication is rarely to be encountered anywhere—understandably so since the 80-hour work weeks, which make it possible, and that Dr. Colangeli mentions, eventually exact a heavy toll on all members of the team. (Yes, I am one of the donors listed at that site, though I won't tell you which one! I try to walk my talk.)
I noticed there is no option to change the euro sign to a dollar sign. I'm going to contribute in euros I guess and see what happens....hate to mess around with the unknown when the card is concerned.
There was no problem at all in using my American-based Visa card to donate. The Go fund me site asks you only how many Euros you want to donate. (The current exchange rate is $1.14 per Euro, so if you donate, say 10 Euros, you will be charged $11.4.) The credit card system automatically makes the conversion to dollars (francs, roubles, whatever is relevant) and debits that from your account. The whole donation process was effortless and took maybe 2 minutes total.
Funny side note: the minute I clicked "Donate," my phone rang. It was my bank's fraud prevention service. The fact that an American credit card was being charged for an organization in Italy had triggered their suspicion. They told me it was for Go Fund Me HDT, and told me the amount of the charge in $$. When I reassured the automated system that, yes, I had actually authorized the charge, they lifted the automatic block they had put on the card.
Marco, thanks for updating us about the good Doctor. Our positive thoughts, and best wishes for a speedy, healthy recovery....Glen Horsmann aka Ole Hoss
My thoughts and prayers go out to the doctor. Don't even know how to say thank you to somebody so dedicated, to a disease that is not on the radar. And thank you also and all the people that have touched This research and us. Speedy recovery. Mary
January 28, 2019
Dear Marco,
First, full wishes for a smooth and successful recovery to Dr. Costantini! Second, please let him know that we are concerned and that he is in our thoughts and prayers. Third, a very big thank you and nod of appreciation to both of you for the tremendous amount of time, dedication and effort that the HDT Team has put into helping so many people!
To Dr. Costantini, thank you for showing me what a truly caring doctor is, you are a one in a million and would make a great role model for other doctors to follow! It has only been a few days and already you are missed! Thank you for all that you do to help others! Take all the time you need for your full recovery and best wishes going forward!!!
Thank you, Dr Marco, for keeping us informed. I'm keeping Dr Costantini and all members in the HDT team in my prayers and thank you all for the selfless laudable job in caring for all of us. Keeping you all in my prayers.
Totally agree. I posted the same on the B1 Thiamine group. I Have donated once but will donate again as as I can.
As a retired nurse I’m fully aware of the time taken answering all those emails which not only is unpaid but takes time from family and friends. In the UK due to lack of NHS funding and services, firstly, I haven’t donated the total amount of what it would have cost me privately plus even paying privately still would not have got the service he has provided.
Hopefully, so that his whole team can invest in recourses to help them gain a better work life balance we will see a gradual increase in the fund.
The only thing is could the link be added to the original posting of the letter of Dr Costantini So that it’s not hidden in the replies. Let’s make this fund grow folks.
Thank you taking very valuable time and letting us know a bit more about Dr C.
I think that EASILLY (Art) share speaks for many of us on this site. I too keep Dr C in my prayers and daily thoughts.
I am not a PD person, but the mom of a child who at 55 years of age died of PSP (May 4, 2017). I visited this site for three years until my son was re-DX with PSP. I am 78 years old and though I do not suffer from PD I do suffer from many aches and pains, especially on my legs (since 1974 I do a 4 mile early morning walk five days a week). I read about Dr C's protocol and decided that I had nothing to lose and much to gain. I started the thiamine August, 2018, very LOW dosage. I now take 500mg at breakfast and 500mg at lunch. I swallow so much better, I can easily move my neck, I am not as stiff after sitting for a long period. Thiamine seems to be a "tonic" for age.
I reside in Los Angeles, CA, USA. I am of Mexican descent on both my mom's and dad's side. So, I did not worry when it was shared that Dr C had some concern on how the thiamine was working on those of Anglo-Saxon heritage.
I think Italy is a very beautiful country, but then I have come to find out that all countries are beautiful. When my son was barely 14 years of age, and his sister 13 years of age, I took a $3000 loan from the credit union and bundled my two kids up and off we went to Spain, Italy, and Greece... a total of 6 weeks, 1976. I planned it all out without guides or tours, of course their wishes were Pompeii. We stayed in very inexpensive pensiones. My son was enthralled with Italy (and they got to see Pompeii). I am always grateful for that decision. It compensates for my "wish" that I had heard of thiamine before my son died and had tried it on him.
Marco, I give thanks to both you and Dr C.....for all the good you do.
Thank you for taking the time to let us know what is going on, Marco. One thing I would like to emphasize that has not mentioned by the others – is of utmost importance that you, Dr. Costantini, and the rest of the team make your own self-care the top priority. Please do not burn yourselves out for the sake of we patients. Much better to have you around with reduced availability than to not have you around at all as a result of burnout.
Oh Marco, I am so sorry to hear this. I alway wondered how he coped with the huge amount of emails and patients he deals with. Wishing him a swift recovery and thank you for the update. He is an amazing man and please give him our love and best wishes from NZ ❤
While I am not following the HDT I very much admire Dr. Costantini for his generosity, compassion, and commitment to people with Parkinson’s. Please let him know he is in the thoughts of many people.
Dr. C. As we all know, life is not always easy when not feeling well, but I hope it speeds your recovery to know that others are thinking of you and praying you'll be better soon. God Speed. We are all fine while you take good care of yourself. Much Love 💕
Thank God for this doctor. . he is one of a handful in all the world, who believes in the Hippocratic oath he took and honors that oath daily! Blessed Be!
So sad to have this news of Dr Costantini. I am not a PwP but my husband was. I offer my grateful thanks to Dr C and his team --to you Dr Marc-- for all you have done for those who suffer from this cruel disease. May he and you be greatly blessed. Dr C is in my heartfelt prayers for a swift recovery.
Thank you, Dr. Marco, for this information! Many people in the Parkinson’s community, here, have been helped by Dr. Constantini and you, of course. I am very sad to hear of the good Dr.’s health misfortunes, and I will pray fervently for his recovery to good health. We have a very dedicated Doctor in our immediate family, who is very caring, and gives of himself so much, that he sometimes neglects his own well-being. So I can relate to Dr. Constantini overworking, to the point of neglecting his own health. It is rare to find such a caring Dr., as Dr. Constantini is, who wants to help those of us who suffer from Parkinson’s. Dr. Constantini is compassionate, and knows what to do to help! Again, wishing Dr. Constantini a good recovery, and always the best for such a wonderful physician, who cares!
Dear Dr.Colangeli, thank you for taking your time to inform all of us here on HU about Dr. Costantini's health problem. We were worried about his well being, but thank God he is now recovering in the hands of good Italian doctors. Please pass on to him my most sincere and heartfelt wishes for a speedy and full recovery. I owe him, you, and the rest of the team my husband's daily improvements.
As I wrote before, he is a RARE BREED. God bless him.
Sincerely trust that Dr Costantini will make a quick and full recovery and thank you to all his staff for the dedication to helping all of us control our Parkinson's.
Buongiorno, ho portato da non molto tempo mio marito a Viterbo dal Dottore, abbiamo appena avviato il primo ciclo di iniezioni per 40 gg per cercare di contenere un Parkinsonismo PSP purtroppo molto importante. Sapevo che il Dottor C. doveva affrontare un intervento, spero di cuore che le complicanze possano risolversi prontamente. Auguri di cuore
Good morning, I have not long since brought my husband to Viterbo by the Doctor, we just started the first cycle of injections for 40 days to try to contain a PSP Parkinsonism unfortunately very important. I knew that Dr. C. had to undergo an operation, I sincerely hope that the complications can be resolved promptly. Heart Wishes
Thanks Marco for your news, I hope that Antonio recovers quickly.
I am one among many PD sufferers who have been following his treatment therapy with great results, but without being in touch with him.
He is a remarkable and wonderful human being, who deserves appreciation from the scientific community. If it works, applaud it - don't worry about how it works!
Thank you Marco. I wish for Dr Costantini all the very best for a speedy recovery and for the opportunity for him to focus on his own wellbeing. He does so much for others... it is time for himself now.
Dear Marco, my husband (Tony Bienefelt-Australia) and I send Dr Costantini our best wishes for a speedy recovery and we sincerely hope he takes all the time he needs to fully recover before returning to work. Our thoughts and prayers are with you all !!
We would also like to encourage anyone who has benefitted from the HDT to donate on the Go Fund Me page.
We weren’t involved in setting up the page, but we’ve been given hope (having recently started HDT) and have donated on the Go Fund Me page. Thank you Marco for setting this up!
Marco, thank you for letting us know about Dr. C. What a blessing you both are to so many of us. Thank you to both of you for your grace, love, and dedication to healing the body, mind and spirit. Prayers being sent for a full recovery.
I send thoughts, prayers and gratitude to Dr. C, and to you, for all you have done for this community so generously. With hopes for his speedy recovery, and the knowledge that there are so many of us who wish him well.
Please convey to Doctor Constantini that I am fervently praying that he will return to good health. He has impressed me with his compassion and devotion. Thank you, Marco, for taking a moment from what must be a busy schedule to update us on his condition.
Thanks for your post. Wishing Dr. Constantini a full and speedy recovery. I started his HDT protocol just two months ago with some positive results, which has given me hope for a better future. I am eternally grateful to Dr. C, and his team, who give so unselfishly of their time. Please let him know how much we all appreciate him and are wishing him the best possible outcome.
We thank you father for all you have done for us, for Dr. Costantini and his generosity. In Jesus holy name we thank you for Dr. Costantini's speedy recovery back to divine health.
Please send Dr Constantini my best wishes for a speedy recovery.. I will always be grateful for his wealth of knowledge and care which has made me feel so well. X sue webster, england
We are all so sorry to hear of Dr Costantini's illness. If only we could return to him some of the wonderful healing that he has made possible for so many of us.
Sending prayers for a swift and complete recovery to Dr. C. Thank you Dr. Marco and Dr. C for all that you have contributed to improving our quality of life. I have shared your work with my primary care physician and she is very interested in communicating with you in the future.
We all are concerned. I hope he recovers well and gets enough strength for all his future endeavors.
Dear Marco,
As you can see from the response on this thread, there are many members on the forum who are concerned about Dr. Costantini and how he is doing health wise in his recovery.
I don't know if it is possible or practical for you to update us and I certainly want to respect Dr. Costantini's privacy, but if it is possible, maybe an update every week or every other week would be greatly appreciated on this end! If there is a conflict of any type and regular updates are not possible, just disregard this request. Thank you for your consideration and please let Dr. Costantini know that we miss him and continue to keep him in our thoughts and prayers for a full recovery!
We are truly grateful for all the demonstrations of true affection you have posted on this forum. Thank you each and everyone for your kind words.
Dr. Costantini is slowly getting better. It is still too early to tell with certainty but there are positive signals. He should be released from intensive care tomorrow and will start a period of rehabilitation.
I will make sure to tell him about your messages as soon as the time is right.
Thanks for the update, Marco. He is in my thoughts and prayers every day. Wish him a full and speedy recovery. My mother spent a few days in the ICU and I know the feeling. She fully recovered although she was 87 years old.
I will continue with HDT as you taught me, because it is so simple and so effective for me.
Like the ancient knights you and your group are in the front line to bring hope for a future world where neurodegenerative diseases such as PD will no longer be so frightening.
The task was not easy, we know, but the tiger, (metaphor of the PD) is a tiger of paper now.
Marco. I am so sorry to hear that Dr Constantini is unwell. His B1 protocol has certainly made life changing differences to my pd. I have two questions which I now ask of you, if this is not possible to answer, I do understand. They are.... does Dr Constantini advocate having a break from b1periodically, and should I be taking some dose of magnesium. I hope you could just answer these as I can find no didinitive answers on the net. Please continue your wonderful work and I hope someday there will be a formal trial worldwide into this wonderful regime. Sue webster
With this message I would like to update you on Dr. Costantini’s condition. First though let me thank you all so very much for the unbelievable display of affection, your thoughts and kind words for him, and for us all really, are so very appreciated. This is heartwarming and it fills me with joy to know we have a community of patients and friends on this forum.
The planned surgical procedure was a carotid endarterectomy. Sadly a few hours after the procedure was concluded, Dr. Costantini’s heart had an episode of fibrillation. Before the fibrillation was controlled by the medical staff it had caused a coagulation and consequently a stroke.
Very regrettably, Dr. Costantini reported motor impairments consequent to the stroke. He left the intensive care section of the hospital last weekend and since this week he has been transferred to a rehabilitation structure near his hometown. He has been having his closest friends and family around him.
Antonio is making progress. Although the consequences of the stroke were severe, the critical few days that went by have shown a positive trend.
However, the rehabilitation will take time and it is too early to tell when he will be back in shape as we truly hope he will, at some point.
As Dr. Costantini really needs to focus on his own health this time, it is of the utmost importance that our research is embraced by other scientists in collaboration with us through a multi-location formal trial. Now even more than ever before.
I will dedicate all my time and energy to trying to secure a prosecution of the work done to date for the benefit of the current and future patients.
Thank you all for your understanding and apologies to those who have been seeking our attention and have not received it yet.
Thank you so much for the update. There are some members here who have reported neurologists who are open and receptive to HDT. Would it be helpful for them to ask their doctors if they are interested in collaborating?
Dear Marco, thank you for this update! Again best wishes to Antonio for a good recovery.
I will continue to use HDT as you taught me. Thank you for all the work you are doing for us and for a future world free from neurodegenerative diseases. I am convinced that the combined will of us sick people to intensely want a cure is part of the solution.
We at HU are grateful to all the researchers like you and Antonio and we strongly want the result as you want it. We all together form a team that work shoulder to shoulder with the aim of defeating the disease.
The sun never sets here on HU and its people as it always shines on HDT.
I posted the following as a reply to forum member Despe, but I am adding it to this thread because it really belongs here where more members might see it :
I had previously mentioned to a couple of members that what Dr. C was offering us was a gift with a limited time attached as he was already semi-retired so for those who were able to get benefit from his offer, well they were very, very fortunate!
The serious nature of a stroke aside from the obvious physical limitations it can impose on the patient, can sometimes change a person's outlook on life as well as realign their priorities. Although helping his patients is a top priority for Dr. C, his immediate health is now a new top priority for him and I imagine that trying to establish his protocol in the medical community has also been pushed a little higher on his priority list as he comes to terms with his present situation. As far as the rest of his team, I think they may have their hands extremely full now trying to take care of his in office patient load. Given these current circumstances it may not be a realistic expectation to think that they will be able to pick up the extra burden of the email patients until they say otherwise.
Hi Marco, Thanks for the update. We are worried for Dr. C. We pray for him to recover quickly. I've read the book "The Magnesium Miracle" by Dr. Carolyn Dean page 78/79 it says Dr Bruce Rind and Dr Sean Dalton developed RELOX procedure for stroke, which consists of an intravenous vitamin mineral solution, with a heavy emphasis on magnesium, and the simultaneous application of oxygen by mask. Daily treatment wth success. In one patient mentioned in the book, he was given added hour-long sessions in a hyperbaric oxygen chamber to further enhance the delivery of oxygen to the brain.
The book says Good neurosurgeons give magnesium (magnesium sulfate) to all their surgical patients, Magnesium helps the brain recover from brain surgery, magnesium can prevent post-surgical strokes or make them less damaging.
Magnesium sulfate also acts as a general anesthetic so other chemical anesthetics can be reduced.
Does this help to look into it for Dr. C please?
We wish and pray for Dr. C.'s speedy recovery.
Sorry if I go off the topic, but I am concerned about him. Thanks.
Dear Marco,
Thank you for this update! I will continue to pray and keep positive thoughts for Dr. Costantini in this recovery process!
Truly sorry to hear about Dr. Costantini's stroke - may he be surrounded by our prayers and the divine healing power so that his "youth is renewed like the eagle's" (Ps.103). Best wishes and many blessings to this dedicated doctor, his family and you Marco.
My heart has just sunk! Thank you Marco for the update, and please take care of yourself. Every day I look at Dr Costantini’s kind beautiful face on the highdosethiamine.org website and pray for his recovery. It is just so unfair for him to be suffering. Sending love and healing.
I just saw the update on Dr Costantini’s medical condition. I wish him a speedy recovery. His novel treatment for PD and being a true human being made hundreds if not thousands of PwPD and their loved ones feel better.I am really greateful of finding Dr Costantini and would appreciate his contribution to my well being every day.
There are a few updates about Dr. Costantini's condition and future, but before I jump into that I need to apologize on behalf of our group for not being able to keep up with all the requests of help received via email and through the website. This is due to the obvious constraints you all can imagine we have now that Dr. Costantini is recovering and unable to work, though since our priority is to help the patients we need to manage our time, resources and energy strategically.
Dr. Costantini's recovery continues positively. Sadly though, the stroke has damaged some areas of his brain causing movement impediments. Unfortunately, these are severe but luckily the rehabilitation center that is hosting him is very well equipped to provide him with the best cures and therapies available. This however, means that for a considerable amount of time, likely many months, he will not be able to get back at work and definitely no longer take over the huge amount of consultancy work he used to do, sometimes for even 14 working hours/day.
This is why we are channeling our - now even more limited - resources to guarantee the continuation of the experience with the HDT protocol, and to support PwP who have not taken B1 yet or are unsure about the right dose with this therapy.
Thanks to the invaluable help of a member of this forum, we managed to get in touch with the Michael J. Fox Foundation recently who informed us about publicly available funding opportunities for the research on PD. We are going to put all of our efforts into preparing the best funding proposal possible to make the most out of the limited resources and time availability we have now. The goal is to invest our time, including (if possible/appropriate) Dr. Costantini's time, to develop this proposal which will involve the clinical trial of the HDT protocol on a multi-location, international basis. To this end we intend to partner with research centers across the United States, Europe and elsewhere (compatibly with the requirements of the call for proposals) and supervise and carry out the clinical trial. In this way, patients will be given the opportunity to test the HDT protocol but instead of having the entire burden on our emailboxes, there will be other Neurologists and Practitioners that will be able to follow the treatment with Vitamin B1 in person rather than remotely. If funded, the trial and its results would be able to inform on the effectiveness of the HDT protocol, and if said results as we hope will be positive, they will allow other patients after our activity is concluded to try the HDT therapy in those research centers worldwide. This could happen without our direct involvement, which we could never offer given the magnitude and the number of requests we receive.
I will keep you posted on the next steps and if anyone is interested in being part of the trial you might contribute to the research as well as have the opportunity to test the HDT protocol for yourself, under direct, in-person medical supervision.
Thank you very much for the update Marco! Best wishes for Dr costantini speedy recovery! It sounds like great news that certainly would not have got this far if not for all your incredible effort!!! Thanks again! Steven
I was the forum member who talked with the MJFF Chair Todd Sherer and with Sara to initiate this effort for them to have their research staff reach out to you. I am very hopeful that this will lead to funding of a trial of B1 so that data can be gathered and hopefully lead to spreading of this treatment and more knowledge of the scientific basis.
I also think there are a variety of other promising approaches that should be studied beyond just pharmaceuticals. This includes some other supplements like liposomal glutathione, procedures like external brain stimulation or using hyperbaric oxygen chamber, and possibly fecal implants to change gut bacteria.
Based on my conversation with MJFF, I encourage everyone to use their Fox Insights portal to share their experiences on B1 or other treatments. This helps them see what might be working for patients and then funnel research money to these areas.
Additionally peple are donors to MJFF or any other PD organization, as you make your gifts, also encourage them to support research into non-pharmaceutical approaches as well. This is a complex disease and we need to look in many places for things that can help.
I hope this connection works to create a study and wish Dr C a full recovery.
I was saddened to hear of Dr Cs health. After reading all the wonderful posts I was planning a trip to Rome to visit him personally. I understand you worked closely with him and I would be willing to travel to Genoa and visit your office to secure the correct dosage and monitoring of the B1 regimen and/or be part of your clinical trial. Would that be possible? I live in Boston And I’m willing to travel. Hope to hear back from you!
Thanks Marco for the update. We wish Dr Costantini a speedy and miracle recovery. He and you and the team deserve the best because of your generosity.
Please include Australia for the protocol. Thanks very much!
I am adding this cut and paste of two posts to this thread in the hope that Dr. C might see it because these two posts describe exactly what Dr. C has said he would like all members who have benefited from his HDT protocol to do, let your doctors and neurologists know that it is because of HDT. Not all doctors are open to the idea of HDT, but if nobody tells them, how will they ever find out about HDT and the tremendous potential it offers to PWPs and other neurodegenerative conditions?
Today I returned from exam by my neurologist. Walk and turn test? Passed. Pull Test? Passed. Next appointment in one year. Today my neurologist broke from his resistance and said he will look into thiamine hcl. My neurologist said carbidopa levodopa is not useful with tremors. He said its function is to get you moving. I am trying to post today's pull test video. Watch for it.
Hi dott. Marco, I take this opportunity to ask for informations on the health status of dott. Costantini and to ask if another neurologist replaed him on B1 in patient visits.
Hello Marco, this is Sara, you probably heard about me from Dr. Costantini. We were so sorry to hear of his heath issues. I posted the stopparkinson.org/ info website, hope that can help. Please let me know if we can do more.
The recovery of Dr Costantini continues. The hit has been serious and the recovery requires time. He will soon be transferred to another structure where more rehabilitation procedures will be available and less intensive care is foreseen. This is good news but we remain cautious.
Over the past months we have been working on finding support to provide patients with consultancies while Dr C is recovering.
One of our most trusted neurologists has offered his availability to help international patients who are in the position to attend in-person visits and check ups in his office in Genoa, Italy.
The email-type of support that was offered by Dr C unfortunately cannot be guaranteed by the other neurologists we know.
In case anyone is seriously intentioned to travel to Genoa for an in-person visit & advise on the HDT therapy please Direct Message me and I will share his contacts to make the connection.
An update while Dr. Costantini continues recovering. Months after his surgery he still not fully out of danger, and this is the clear sign that the hit has been important and his condition is serious. He talks and interacts well but his vital parameters still need to be monitored 24/7. It is clear now that he will not be able to resume working as he used to, but he will only be able to have an advisory role for the other members of his group.
In the meantime I was contacted by a member of this forum requesting news about the funding campaign. This is surprising as the GoFundMe campaign, as all crowdfunding campaigns, is fully public and the rules are quite straight forward. The funds are to be used exclusively for the terms of the agreement published in the announcement of the campaign itself, thus solely when the target amount is achieved the funds will be spent exclusively for the purpose of carrying out the scientific research connected to the funding campaign. We are still very far from achieving the set goal and this is why in the meantime we have been looking for additional funding opportunities.
On a more relevant note, I would like to call upon the contribution of members of this forum with involving clinics and hospitals who could participate in a clinical trial on the efficacy of the HDT therapy. As you know, we are relentlessly trying to carry out a double-blind placebo controlled clinical trial on the HDT therapy and for this we have applied for grants offered by a major institution in the research on PD. One critical aspect of the research is the necessity to gather a representative sample of patients with a decent geographical distribution.
To this end then, if members of this forum have contacts with potentially interested clinics/hospitals/research centers that are in the position to carry out clinical trials under our supervision (recruiting and following a relevant number of patients - 25 or more - ) as Co-Investigators and have experience with clinical trials on PD, it would be very important that you put a focal point from these institutions in touch with me.
Do you have the time to copy and paste your update into a new post? I believe it will reach more members that way, especially those who have doctors who are supportive of HDT.
Thanks for the update! We are not near any such institution for B1 clinical trials. The closest university hospital to us is Vanderbilt (2 hrs driving). I can ask our (husband's) MDS at Vanderbilt if they would consider B1 trials.
Another quick update on Dr. Costantini's situation (and more).
I had the chance to see him twice this and last month and can report some further improvements. He was very happy over the Holidays when all his loved ones came to visit him, he is finally in a clinic in his own hometown, Soleto, Italy. He knows everyone there and everyone knows him and that familiar setting is really helping with his improvement. He can sit on a chair for long hours before feeling tired and is regaining slowly several movements and capabilities to control his body. With support from paramedics he can stand up and chances are he might be able to move some steps on his own at some point. Fingers crossed!
And along the lines of hoping for the best, I am happy to announce that we submitted the full proposal version of the study on High Dose Thiamine (thanks for the support to the Docs here in ITaly and to at least two very precious members of this forum who supported me in this endeavor since the beginning) to the MJFF. We should all keep our fingers crossed for this study to be evaluated positively so that the good work of Dr C can be taken forward by others and for the benefit of many in the PD community.
So I hope this hopeful message finds a smile on your faces as it has left one on mine, wishing you all a wonderful weekend, it's time to get back at work for me!
MARCO I am getting ready t begin the HDT protocol with an initial dose of 4 grams pf powder mixed in with some yogurt.. I am 5'7"and I weigh 220-225lbs do you think that 4 grams is enough to start with or can you recommend some thing differentI await your reply thank you jim
Basic (B) - (1) 1nstructions. B1 in the form of thiamine hcl is required for HDT (high dose thiamine) therapy.
Regarding thiamine hcl, it is not a cure. It is at its best supporting carbidopa levodopa. Solgar tablets are choke hazard. Find capsules as they are easy swallow.
Doctor Costantini directed:
Early or mild symptoms - 2 grams daily.
Moderate symptoms - 4 grams daily.
Severe symptoms - 6 grams daily.
Divide into two equal doses. Take first dose at breakfast. Take second before lunch.
I
Before starting with full dose take a small amount and watch for any allergic reaction.
Continue to the GUIDE - click on See All . Facebook group: Parkinson’s thiamine hcl
THANKYOU VERY MUCH I APPRECIATE THE GUIDEI WOULD HAVE DEFINITELY OD'D on what I was contemplating on taking...will let you know how it affects me...k thanks again
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