It is increasingly evident that Parkinson disease (PD) is not a single entity. PD is a heterogeneous disorder, meaning no two individuals have the same symptoms, disease course or treatment response. Defining subtypes of PD further helps understand underlying mechanisms, predict disease course, and help design personalized management strategies.
For example, 4 core Parkinson's disease subtypes:
(1) younger disease-onset,
(2) tremor dominant,
(3) non-tremor dominant, and
(4) rapid disease progression.
The common denominator? Alpha-synuclein protein clumps (Lewy bodies) appear to be as they are seen in the brains of nearly everyone with Parkinson's. This provides new insight and could change how Parkinson's is treated.