Parps.

[rossnbren]

Hello Ladies.. could someone tell me whether you need a tumour sample or what other criteria maybe needed to be prescribed Parp-inhibitors . I’m on 2nd line recurrence and feel I’m running out of options. thankyou.. big hugs to allxx

[Katmal-UK]

Your Oncologist should be able to advise. do you know if you have the BRAC gene? Where are you based? xx

[rossnbren in reply to Katmal-UK]

No I’m not BRAC and I live in Australia.

[caf132]

I can only get on Keytruda if I have the PDL1 tumor marker. Being tested now. I am braca neg

[delia2]

Hi. There are three approved PARP inhibitors which have slightly different protocols regarding being BRCA positive or negative. But at this point you should qualify for one of them. I think you need to partially responsive to platinum to qualify but there are trials combining them with other drugs for people who are platinum resistant. Ask your oncologist.

[rossnbren in reply to delia2]

Thanks Delia

[bamboo89]

Niraparib and Olaparib are approved in Australia (can't find a mention of Rucaparib) and one basic criterion is you have to have responded to a platinum based chemotherapy. In the UK, assuming you respond to platinum chemo, you have to start the drug within a maximum of 8 weeks after finishing chemo, not sure if that's the case for Australia.

It is a great pity they don't routinely test OC tumours for BRACA - its possible for the cancer to be BRACA while you are not, and if the tumour is BRACA, PARPS are more effective. So far as I can tell, they have now started routine testing in the UK, presumably since the advent of PARPS.

Miriam

[rossnbren in reply to bamboo89]

Thanks Miriam.. just wanting to know what my options are if present chemo doesn’t work.. crazy isn’t it, this disease can be all consuming.

[bamboo89 in reply to rossnbren]

It's exhausting, so many decisions to make all the time... but if your chemo doesn't work at all and its platinum based, then they won't offer you a PARP because it won't do anything.. The idea is, the chemo knocks the cancer back, and the PARP just slows down its return... how long it slows it down for is anybody's guess...varies between 5 months and some years.

Miriam

[rossnbren in reply to bamboo89]

OK👍