I am newly diagnosed with seropositive RA and was on 10 mg of methotrexate. I also take Tramadol for pain and folic acid every day except the day I take the RA medication. I have been raised to 15 mg of metho and have taken it for 2 doses. After taking my last dose I have been in bed for the last 3 days. I could barely walk yesterday and my body just aches, especially my legs. Muscles feel like I have started a new program of exercise if you know what I mean. Nausea is almost ever present but not to vomiting stage. Is this the norm?