My wife has WM. IGM 2200 - 18 months of Ibrutinib @ 420 per day IGM drops to 145.
All ok until Bilirubin abnormal 6 months ago.
Changed dosage to 280. Bilirubin now normal. All other blood work normal but IGM started to increase now @250.
My question is this. Does this rise in IGM suggest a new normal due to reduced dosage?
Or does this suggest that IBrutinib no longer effective?