Stepping out of antiquity: An update on emerging drugs for the treatment of polycythemia vera

[Manouche]

Abstract

Introduction: Polycythemia vera is a chronic hematologic malignancy frequently presenting with constitutional symptoms and associated with an increased risk of thrombosis, hemorrhage, and progression to myelofibrosis or acute myeloid leukemia. Current treatment strategies reduce thrombohemorrhagic risk by controlling blood counts and inhibiting platelets, but often fail to address disease-relate symptoms or biologically modify the disease.

Areas covered: We review the current paradigm for treating polycythemia vera, highlight areas of unmet need, review therapeutic agents in late stage clinical development, and provide an overarching view of how these emerging agent may fit into the future armamentarium of polycythemia vera treatments.

Expert opinion: The shift from focusing solely on secondary prevention of thrombohemorrhagic events to a comprehensive treatment strategy that additionally aims to improve quality of life and prevent disease progression has resulted in a rapidly evolving therapeutic landscape that promises to move the treatment of polycythemia vera out of antiquity into the modern age.

pubmed.ncbi.nlm.nih.gov/341...

[Aldebaran25]

Thanks for this. From the link it looks like at the moment only the abstract is available, unless I missed something.

[lhammy66]

Looks locked behind a paywall but will try on Monday to access through my uni- not sure if they have access to this journal or not but will try