Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera

[Manouche]

« Elimination of MPL expression completely abrogated the polycythemia vera phenotype in this JAK2V617F transgenic mouse model, which could only be partially restored by expression of one MPL allele. These data indicate that polycythemia vera is in part a thrombopoietin-dependent disorder and that targeting the MPL-thrombopoietin axis could be an effective, nonmyelotoxic therapeutic strategy in this disorder »

journals.plos.org/plosone/a...

[EmeraldA]

This is very interesting indeed! Thanks for posting.

[MPort]

Thanks for posting. So a new initialism (I had to look this up!) MPL. I started to read this but will need to come back to it. Can you summarise in simple sequence what this means? I am trying to extract the essence. Ie JAK2 is prompted by this MPL level? Remove or control the MPL and inactivate JAK2? Didn't get to how this is done. It's great that you find and post this research. I expect it will come to the fore in the future but we get a glimpse of it here thanks to you.