Nicotinamide which one?

[stephanie1977]

Hi,

I see many people are supplementing with vitamin B3 for their glaucoma based on trials in Australia and now in England.

Nicotinamide mononucleotide (NMN)and nicotinamide riboside (NR) are the two types.

Which are people trying,how much and why?

Thanks!

[P0inteN0ire]

I've been taking B3 supplements for about 6 months, 2 X 1000mg per day.I've just looked at the bottle and what I have been taking in Niacinamide.

From the message above, I wonder if I may be using the wrong thing.

If anybody has a definite answer I'd be very interested.

[goodtotalk in reply to P0inteN0ire]

I just noticed a comment on a different post on this forum & it said ‘nicotinamide, also known as niacinamide’.

[P0inteN0ire in reply to goodtotalk]

Many Thanks.

[stephanie1977]

I do know that members blackdog76 and muddleme have been taking Nicotinamide.

[stephanie1977]

From what I understand from doing a bit of research is that it should be Nicotinamide mononucleotide , at least that's what the Australian study used with good results

[haraba]

Hi,

I am currently not taking any nicotinamide.

I have read that both nicotinamide mononucleotide (NMN) and nicotinamide riboside(NR) are precursors in the synthesis of nicotinamide adenine dinucleotide (NAD+), which is in all cells and used in cellular repair and other biological processes. Some glaucoma which progresses, despite the IOP being lowered and normal tension glaucoma (NTG), (which I have) may be linked to lower levels of NAD+. The NAD+ is helpful and what will increase that to a safe but beneficial level (and at an affordable cost) is not certain. From my reading, NMN appears to have more in favour of it than NR.

NMN is found in small amounts in some foods eg broccoli, cabbage, avocados, edamame and cucumbers. In mammals, most NMN is synthesised from vitamin B3 (niacin). Although, the current recommended dietary allowance (RDA) of niacin equivalent is 16mg per day for men and 14mg per day for women, I have read that 21mg/day or more produces a lower risk of glaucoma. Not sure if the benefit is the same once you been diagnosed, but would hope that the progression is slowed significantly. At the moment, I am just thinking of taking Niacin.

I have seen NMN doses on websites of 250mg/500mg and 1G per day. There are possible side effects, which depend on your unknown individual susceptibility.

[Hope4luck in reply to haraba]

The original Australian trial used Nicotinamide. It was called "Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial". Methods: Participants received oral placebo or nicotinamide and reviewed six-weekly. Participants commenced 6 weeks of 1.5 g/day then 6 weeks of 3.0 g/day followed by crossover without washout. Visual function measured using electroretinography and perimetry. Conclusions: Nicotinamide supplementation can improve inner retinal function in glaucoma.

The problem with taking Niacin is it can cause flushing at high doses. Nicotinamide does not cause flushing and is a lot cheaper than the nucleoside or riboside derivatives.

[stephanie1977]

Dont know what to think! Came across this article:

express.co.uk/life-style/he...

[Welshsailor]

that’s interesting. On FitEyes.com it also mentions about B3 causing an increase in pressure. pubmed.ncbi.nlm.nih.gov/187...