‘Game-changing’ operation cures prostate cancer in one hour

[George71]

I wonder if this procedure would be better for targeting visible PSMA spots and lymph nodes ? It can be repeated in same area -- unlike radiation.

by: Dr. Mary Gillis, D.Ed.

Posted: Aug 22, 2022 / 06:02 PM EST / Updated: Aug 22, 2022 / 06:02 PM EST

wishtv.com/news/medical/gam...

[Lyubov]

If only. . . but sounds too good to be true!

[NPfisherman]

So many new treatments becoming available. We'll have to keep our eyes open, especially when they do Phase 2/3 trials... As I like to say, stay alive for 5 more years, and new treatments may keep you alive for 5 more...

Thanks for posting, George... As I said, post what moves you.... but be self moderated... lol ..

Fish

[cujoe]

George,

Thanks for posting. It seems NanoKnife has been in PCa trials for about 20 years now. It is just one of several "focal therapies" used for PCa that is confined to the prostate. I'm suspicious that if it were truly the "game changer" referenced in the TV news report it would have long ago found its way into mainstream practice. Also note that the doctor singing its praises, Dr. Mark Emberton, is . . . a NanoKnife consultant.

At best it looks to be just one more treatment tool that MIGHT be appropriate for some patients. The promise of quick recovery from the procedure and minimal impact to ED and continence are allurring, but have not yet been convincingly verified - and long-term cancer-free outcomes look a bit shaky to me.

Here is a link to the NanoKnife Corporate (angiodynamics) website:

angiodynamics.com/product/n...

There are 12 CTs listed at clinicaltrials.gov for PCa+nanoknife.

clinicaltrials.gov/ct2/show...

Note that the following trial (Preserve) is now recruiting at numerous sites around the US:

clinicaltrials.gov/ct2/show...

Here is what Angiodynamics has to say about the Preserve Trial:

angiodynamics.com/studies/p...

The published results of the two completed trials are linked below. One is a matched RARP to IFE treatment and the other is an IFE pre-treat before RARP for tissue evaluation of effectiveness.

The correlation between the electrode configuration and histopathology of irreversible electroporation ablations in prostate cancer patients - World Journal of Urology, 2016.

ncbi.nlm.nih.gov/pmc/articl...

Pair-matched patient-reported quality of life and early oncological control following focal irreversible electroporation versus robot-assisted radical prostatectomy - World Journal of Urology, 2018.

ncbi.nlm.nih.gov/pmc/articl...

And finally, the following paper co-authored by Peter Mac's Delcan Murphy highlighted the promise and short-comings of the above study comparing IFE focal therapy and RARP to date.

Getting the Balance Right—The Benefits and Uncertainties of Focal Therapy for Significant Prostate Cancer, by Declan G. Murphy & Derya Tilk, European Urology, URURO-7908, 2018.

sci-hub.se/https://pubmed.n...

Maybe not yet a "game changer" or ready for prime time SOC use, but definitely worth following as a viable option for organ-confined, low/intermediate risk disease.

Paz - K9 Terror

[George71 in reply to cujoe]

Thanks cujoe all good info. I agree may be good for some patients with 3 or 4 small spots, but not wide spread cancer. It may someday be an alternate first treatment option to surgery or radiation.

[cujoe in reply to George71]

Agreed. New options for the next generation of unfortunate PCa souls.

[GreenStreet]

Thanks for posting. Embleton is on the innovative end of PC. I think he has looked at HIFU but started off as a surgeon I think. Will be interesting to see how this goes,

[Cooolone]

The problem with the 3 - 4 spots treated are what is seen at the time. Low burden, low risk patients do well with almost any therapy. But the real issue is the micro cellular activity that we don't see and can't detect. It's all diagnosis dependent of course and having an accurate diagnosis is key. Then the right shoe to fit the foot can be found!

Keep on Truckin'

[George71 in reply to Cooolone]

That is true -- with the better PSMA imaging they may be able to knock it out as it crops up and stay ahead of it. I have read that often it takes 5 to 8 years before the mets become visible via old style ct scans. That is kind of what Dr. Kwon does -- zaps them when he finds it radiation or surgery -- unless it is in an area that cannot be Nanoknifed.