Artificial intelligence helps doctors uncover 3 new types of Parkinson’s disease

[Farooqji]

studyfinds.org/artificial-i...

[park_bear]

Another mistitled news release. Not new types of Parkinson's at all - they merely split up existing Parkinson's into categories of slow medium and fast progressing.

[bassofspades in reply to park_bear]

yeah, really! I was thinking, just what we need, three NEW types of PD! As if the old ones werent enough.

[Gioc in reply to bassofspades]

LOL

Through the observation and study of mice and AI classification, medical science is slowly progressing in small steps towards the observation of Parkinson's Disease in humans.

Perhaps, eventually, someone will soon visit nursing homes to observe individuals in stage 4 of Parkinson's Disease in search of a cure.

Let's remain hopeful!

Greetings from Italy Bassofspades

Espresso coffee with pistachio cream and cream

[Esperanto in reply to Gioc]

I really hope this extraordinary espresso fits into my subgroup's diet!

[Gioc in reply to Esperanto]

Lol

[MBAnderson]

Slow. medium, and fast progression. That's it?? If that's all AI has to offer, they need to change from AI to Artificial Ignorance

[Esperanto]

At first glance, it may not seem groundbreaking, but I find it interesting that there has been also a discovery that each subtype has its own distinct genetic and molecular characteristics. This finding holds potential implications for treatment, as researchers can now explore the possibility of targeting these specific pathways with new or existing drugs. The team has already made some significant discoveries in this area.

[park_bear in reply to Esperanto]

True, but already known for certain variants of PD: pubmed.ncbi.nlm.nih.gov/185...

"disease severity, rate of progression, occurrence of falls, and dyskinesia) and non-motor symptoms (eg, cognition and olfaction) of LRRK2-associated PD were more benign than those of idiopathic PD"

[Esperanto in reply to park_bear]

The study you mentioned from 2008 was one of the first puzzle pieces to be put together. Now, 16 years later, the methods, aided by AI, have greatly evolved, and we are gaining more clarity on the complete puzzle. This includes not only identifying the mentioned 3 subgroups but also exploring potential different treatment approaches. It is highly worth delving deeper into this.

[Ghmac in reply to park_bear]

If metformin can slow progression in fast paced PD why can’t it also slow progression in the other two sub types, inching and moderate?

[park_bear in reply to Ghmac]

Don't know.

[pdpatient in reply to Ghmac]

Where are you getting the information from about Metformin slowing down Parkinson's progression?

[Esperanto in reply to pdpatient]

The study analyzed real-world evidence from 2 large databases and found that Metformin, a medication commonly used for diabetes, may slow down the progression of Parkinson's disease. Metformin has been shown to have potential neuroprotective effects in neurodegenerative disorders like PD (see references 66 to 77 of this study). It activates a signaling pathway called AMPK, which can reduce inflammation in the brain and promote the removal of harmful proteins. Animal studies have also suggested that Metformin can stimulate the growth of new blood vessels and brain cells. Overall, these findings suggest that Metformin could be a potential treatment for Parkinson's disease, particularly for those with a faster progression of the disease.

[pdpatient in reply to Esperanto]

Thank you.

[BeedieBird]

I find this fascinating. The various speeds of progression is worth deeper study without a doubt. A topic I've always been very curious about in terms of different pathways in the brain that progression takes and any correlation to speed of progression. All of this information can be quite helpful when developing treatments that are not 'broad spectrum' but that target different types of Parkinson's.

[Gioc]

Deleted..

I got a reply on the wrong post. Sorry