In pre-clinical models, full behavioral recovery was observed by 16 weeks post transplantation and dopaminergic neurons were seen projecting into the host striatum."
The off-the-shelf therapy in development by TreeFrog uses their proprietary technology, C-Stem™, a breakthrough technology that addresses critical challenges of producing high quality, cell therapies at scale, efficiently. The closed system enables both the amplification and differentiation of cells. The Parkinson's program is the first application of this technology using induced pluripotent stem cells (iPSC) that are differentiated into ready-to-graft 3D microtissues containing mature dopaminergic neurons.
That sounds wonderful. And effective way to produce the cells is a great starting point.
I've heard two complaints from doctors about injecting cells.
1. That they're not programmable to turn off, so you can wind up with tumors. One doctor said that referencing studies in 2014.
2. That they inject in our healthy but then deteriorate in the same way the original cells do. Personally I don't see the problem, so reinject again when needed.
Does It look like this addresses either? Doesn't seem like it's related to what it's solving.
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Presentation by Prof R Barker - University of Cambridge: \"Can we repair the brain in PD using cell-based therapies?\"
Monkeys Aren't Human and Animal \"Models\" of Parkinson's Disease Aren't Actually Parkinson's Disease, BUT This Stem Cell Trial Offers Hope!
\"First ever successful experimental stem cell therapy for Parkinson's Disease\"
