Honokiol, magnolia bark, Relora & L-Theanie what are the differences?

[limcheeese22]

does anyone taking these?

[Bolt_Upright]

Honokiol is in Magnolia Extract. I take Magnolia Extract every day:

14: Magnolia Extract 400 mg (90% Honokiol and Magnolol) before bed. This is supposed to help with REM Sleep Behavior Disorder and be neuroprotective. I get this from Swanson cheap. swansonvitamins.com/p/swans...

I need to write up why I take this stuff. These are the links I need to review (from my notes):

Honokiol, a natural compound to alleviate α -synucleinopathies? Marion Delenclos, Jeremy D Burgess, Priyanka Periselta, Sara Fagen, Natasha DeMeo, Pamela J McLean cdn.ymaws.com/www.worldpdco...

Ramesh S, Govindarajulu M, Lynd T, Briggs G, Adamek D, Jones E, et al. SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway. PLoS One 2018;13: e0190350 journals.plos.org/plosone/a...

Neuroprotective effects of honokiol: from chemistry to medicine 2017 sci-hub.se/10.1002/biof.1385

In vitro antimicrobial and antipro-inflammation potential of honokiol and magnolol against oral pathogens and macrophages 2021 sciencedirect.com/science/a...

Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint 2023 cmjournal.biomedcentral.com...

A New Rabbit Hole: Magnolia Bark Extract healthunlocked.com/cure-par...

Neuroprotective Potency of Neolignans in Magnolia officinalis Cortex Against Brain Disorders 2022 ncbi.nlm.nih.gov/pmc/articl...

[limcheeese22 in reply to Bolt_Upright]

how long have you been taking? how do you fell? any improvement on motor symptom?

[Bolt_Upright in reply to limcheeese22]

I have not been diagnosed with PD. I have REM Sleep Behavior Disorder and a few symptoms of something worse. I am better than I was 2 years ago when I started Magnolia Extract, but then, I do a lot of things: My Stack rbd-pd-protocols.blogspot.c...

[Boscoejean]

"Honokiol was reported to display therapeutic activity on the motor deficits and neuronal degeneration in Parkinson's disease by decreasing oxidative stress and inflammation"

Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis

sciencedirect.com/science/a....

[RBDNoPDYet]

I take 400 mg of Magnolia Extract at night and it has been really helping my RBD. I have not been diagnosed with PD.

[Reetpetitio]

I asked ChatGPT for you -

User

Honokiol, magnolia bark, Relora & L-Theanie what are the differences?

ChatGPT

Honokiol, magnolia bark, Relora, and L-Theanine are all natural compounds or extracts with potential health benefits, but they have distinct differences:

Honokiol: Honokiol is a bioactive compound derived from the bark, seed cones, and leaves of certain species of magnolia trees, particularly Magnolia officinalis and Magnolia grandiflora. It has been used in traditional medicine, particularly in East Asia, for its potential anti-inflammatory, anti-anxiety, and neuroprotective effects. Honokiol is being studied for its potential in managing conditions such as anxiety, stress, inflammation, and various neurological disorders.

Magnolia Bark: Magnolia bark refers to the bark of magnolia trees, particularly Magnolia officinalis. It contains various bioactive compounds, including honokiol and magnolol, which have been studied for their potential health benefits. Magnolia bark extract is used in traditional medicine for its anti-inflammatory, anti-anxiety, and antioxidant properties. It may also have potential in supporting sleep and reducing stress.

Relora: Relora is a proprietary blend of extracts from Magnolia officinalis and Phellodendron amurense bark. It was developed as a dietary supplement specifically marketed for stress relief and mood enhancement. Relora is often promoted as a natural remedy for anxiety, stress-related eating, and improving sleep quality. It's believed to work by modulating the activity of certain neurotransmitters involved in stress response.

L-Theanine: L-Theanine is an amino acid primarily found in tea leaves, particularly green tea (Camellia sinensis). It has a unique ability to promote relaxation without causing drowsiness. L-Theanine is known for its calming effects, and it's often used to reduce stress and anxiety. It may also improve focus and cognitive function. L-Theanine is commonly consumed through tea or dietary supplements.

In summary, while all of these compounds have potential benefits for promoting relaxation, reducing stress, and improving mood, they differ in their origins, chemical compositions, and mechanisms of action. Honokiol and magnolia bark are closely related, with honokiol being one of the active constituents of magnolia bark. Relora is a specific blend of extracts from magnolia bark and Phellodendron bark, formulated for stress relief. L-Theanine, on the other hand, is an amino acid found in tea leaves, known for its calming effects and ability to promote relaxation.

User

Same question with specific reference to neuroprotective qualities and Parkinsons please

ChatGPT

Certainly, let's delve deeper into how each of these compounds relates to neuroprotection and their potential implications for Parkinson's disease:

Honokiol: Honokiol has shown promise in preclinical studies for its neuroprotective effects. Research suggests that it may exert protective effects against neurodegeneration by reducing oxidative stress, inflammation, and apoptosis (programmed cell death) in various neurological disorders, including Parkinson's disease. Additionally, honokiol has been found to modulate certain signaling pathways involved in neuroprotection. While further research is needed to fully elucidate its mechanisms and potential therapeutic effects in Parkinson's disease, honokiol holds promise as a neuroprotective agent.

Magnolia Bark: Similar to honokiol, magnolia bark contains bioactive compounds, including honokiol and magnolol, which exhibit neuroprotective properties. Magnolia bark extract has been studied for its potential in mitigating neuroinflammation, oxidative stress, and neuronal damage associated with neurodegenerative diseases like Parkinson's. Some research suggests that magnolia bark extract may help protect dopaminergic neurons—the cells primarily affected in Parkinson's disease—from degeneration. However, clinical evidence specifically targeting Parkinson's disease is limited, and further studies are warranted.

Relora: Relora, being a proprietary blend containing magnolia bark extract, may inherit some of the neuroprotective properties attributed to magnolia bark and honokiol. While Relora has primarily been studied for its effects on stress and mood, its potential neuroprotective effects have not been extensively investigated, especially in the context of Parkinson's disease. Further research is needed to determine its efficacy and mechanisms of action in neuroprotection.

L-Theanine: L-Theanine, although primarily known for its calming effects and ability to improve cognitive function, has also demonstrated neuroprotective properties in preclinical studies. It has been found to protect neurons from oxidative stress, reduce inflammation in the brain, and promote neurogenesis (the formation of new neurons). While research on L-Theanine's specific effects on Parkinson's disease is limited, its neuroprotective properties suggest potential benefits in supporting brain health and possibly mitigating neuronal damage in neurodegenerative conditions.

In summary, honokiol, magnolia bark, Relora, and L-Theanine all possess varying degrees of neuroprotective potential, primarily through mechanisms such as reducing oxidative stress, inflammation, and neuronal damage. While preclinical studies have shown promising results, clinical evidence, especially regarding their efficacy in Parkinson's disease, is limited and requires further investigation. Individuals interested in using these compounds for neuroprotection or Parkinson's disease management should consult with healthcare professionals for personalized advice and guidance.