Hello All ~ I have started making PS-128 Yogurt. It turns out kind of like kefir which my HwP says is ok. And as a side note, I am using A2A2 full fat milk and my Instant Pot on the 24 hour cycle. I’m making a 2-quart batch and using ½ cup of my previous batch plus one Bened Life PS-128 capsule.
Now my questions are ~
1. How do I know that my HwP is getting enough of the PS-128 probiotic in the yogurt? (He has had major improvements since starting the PS-128 4-5 months ago so I do think these improvements are from this probiotic so I don't want to mess things up. Actually he is the best he has been since his dx 3 years ago!!!)
2. How much yogurt does he need to eat?
3. Can he get too much of this PS-128 probiotic? I have still been giving him one Bened Life capsule at night instead of 2. Is all of that too much?
4. Should I really be using the PS-128 capsule and the ½ cup yogurt from the previous batch?
(He has been eating about 1 cup of the PS-128 yogurt plus the 1 capsule of Bened Life PS-128 for about one week now.)
Any information / suggestions will be very much appreciated!!!
Thank you and have a fabulous day (and Merry Christmas!)
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Lizzy9
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I’m not sure if it is cheaper or by how much because organic A2A2 milk is kind of expensive and I’m still giving him one of the Bened Life PS-128 pills. This mix of yogurt and pill seem to be helping him a lot!!! I feel like in the short time I’ve had him on this regime he’s even more improved ~ nothing I can put my finger on except maybe ~ he’s just “looking”better, responding better, not needing me to help calm him down in the morning at all!! And like I mentioned before he’s better than when he was diagnosed 3 years ago!! So even if it isn’t saving any money it is well worth the cost and effort!
(And I use A2A2 milk because it’s more easily digested (and it tastes really good!!😋))
I have no idea. We do other things for the gut. Seems like I read somewhere that there is a belief that PD can/does originate in the gut for some people. So if it does I am wondering if that is why he is doing so well on this PS128 probiotic in particular? Who knows~~~?
1 if he is using the yoghurt you describe he is getting enough (at least as much as used in the trials)2 a regular 125 GM pot
3 there is no evidence to suggest you can get too much ps128. But if that is your only yoghurt /probiotic then you might be missing some of the benefits of other probiotics
4 in theory you could go on using some of the previous batch as starter culture forever. After all that was how yoghurt was originally made. In practice I use a fresh starter culture (a new sachet) every 4 weeks
Full fat milk is not relevant. The bacteria ferment sugar, not fat
Thank you so much for your information!! That helps me a lot!
One other thing, you said if that’s the only yogurt/probiotic he might be missing some of the benefits of other probiotics. I was wondering if I should add some “regular” yogurt in addition to his PS 128 from the previous batch? He does drink an 8 oz glass of Kombucha with a Tbs. of Fire Cider in it daily.
Hello WTP ~ Would you mind posting a link to the trials that you referred to? I’d like to do some more “investigating”. All if this is such tricky business!
I would be careful of over consuming a particular strain of homemade yogurt. My personal experience many years ago was that this caused blood sugar dysregulation with a very noticeable jump in my glucose readings. Stopped the yogurt and the glucose readings bounced back days later. Our gut microbiome needs diversity and taxing the ecosystem may cause nutritional or other functional imbalance. Just something to keep in mind.
Thank you! I never thought of that. Yes, I’ll definitely keep that in mind! The good thing is that we seldom eat sugar/desserts, etc. But still need to be watchful!!
I rarely consume refined carbohydrates and abstain from adding sugar to my diet. Not only do complex carbs from vegetables and the gluconeogenesis process from protein affect our blood sugar regulation, but the balance of beneficial and pathogenic microbes in our microbiome also plays a crucial role. For instance, extended adherence to ketogenic or very low-carb diets can lead to the development of physiological insulin resistance, significantly diminishing one's ability to handle carbs due to alterations in the gut microbiome in addition to other metabolic adaptive responses. This underscores the importance of maintaining proper microbiome diversity for optimal health.
Ignore the end of the article for Restore, but I otherwise agree with what Zach Bush, MD has to say about probiotics below. This also explains why FMT is so much more effective than other probiotics/antibiotics treatments.
It's worth bearing in mind the origin of modern probioticsLactobacillus delbrueckii subsp. bulgaricus was first identified in 1905 by Stamen Grigorov, who named it Bacillus bulgaricus. Ilya Metchnikoff, a professor at the Pasteur Institute in Paris, researched the relationship between the longevity of Bulgarians and their consumption of yogurt.
L. Acidophilus subsequently was preferred and used in most modern commercial probiotic yogurt. The term "probiotic" tends to get hijacked but originally it was
defined as microbially derived factors that stimulate the growth of other microorganisms. In 1989, Roy Fuller suggested a definition of probiotics that have been widely used: "A live microbial feed supplement which beneficially affects the host animal by improving its intestinal microbial balance."[64] Fuller's definition emphasizes the requirement of viability for probiotics and introduces the aspect of a beneficial effect on the host.
It's not about colonising with a limited number of bacteria, it's about introducing bacteria which create an environment conducive to the many species of nice bacteria and hostile to many pathogens and other nasty bacteria
Grigorov was interested in the reason for the longevity of the yogurt eating Bulgarians
I am FAR from an expert ~ very much new to making yogurt ~ but here is what I do ~ (also, mine turns out kind of runny like kefir, but my HwP doesn’t care. It still tastes tangy and great!)
Here is a link to the website that I found and use for making it. There is more helpful information on this website than I’ve included so I would highly recommend looking at what she says on the website.
And here is what I did after muddling through the website.
I do use an instant pot which is so easy!! Here it is ~
Measure 2qts of milk into the insert of the Instant Pot.
Plug in the pot and put on the lid. I do close the steam release valve. But I don’t think it matters if that’s open or closed.
Press the “ yogurt” setting. Then press the “ adjust” button till it says “boil”. When it’s finished “yogt” comes on the read out panel. You can press the “adjust” button the the “boil” selection if you want to “cook” it another 5 minutes.
After cooking it take the “insert” out of the cooking unit and let it cool to 116F (can take an hour). Carefully skim off the layer of coagulated milk and discard. (Or maybe give it to your cat?)
After it cools put ½ cup in a bowl and add 2capsules of Neutrali PS128 and stir to mix, then add to warm milk and stir to mix that in.
Put the “insert” back into the Instant Pot and lock on the lid. Press the “yogurt” setting till you have the time you want to incubate your yogurt. There’s a setting for 8 hours or 24 hours. The first time I made it I incubated it for 16 hours which meant I had to reset it to 8 hours. The next time I made it I set it for 24 hours since I didn’t want to get up at 2 a.m. to reset it.
After it’s finished gently lift the insert out and let it cool for a couple of hours on the counter then you can put it in the fridge to finish cooling.
I hope this helps. I do use A2A2 milk which is easier to digest.
God bless you and have a fabulous rest of your holiday!!!
I have a question for you regarding PS-128 yogurt. If I remember correctly, PS-128 uses inulin as the prebiotic in the capsules. By using these capsules in the yogurt making process, it seems like you are diluting the small amount of inulin in the capsules down to almost nothing. The use of inulin in the capsules should be helping the original PS-128 probiotic to flourish, but isn't diluting it down to nothing eliminating the positive effects that inulin provides to the probiotic content?
So my question is, are you adding additional inulin to your yogurt to reinstate those beneficial effects that inulin, as a prebiotic, should be supplying to the PS-128 probiotic in the yogurt?
I think adding inulin to the yogurt, if you are not already doing so, should be additive to the beneficial effects of the PS-128 yogurt, should help improve any constipation issues and should additionally increase short chain fatty acid (SCFA) content in his gut microbiome which should also be beneficial. This article discusses inulin and PD constipation as well as how it may also help microglial function :
' Inulin-like fructan consumption can also be beneficial because it stimulate intestinal movements by affecting microflora [130] in PD patients with constipation. Very recently, it has been demonstrated that treatment with microbial-produced SCFAs could rescue impaired microglial function impaired in GF animals [131]. It has been suggested that SCFAs resulting from fermentation of dietary fiber could have epigenetic and neuromodulatory effects through histone acetylation and improve cognitive functions for neurodevelopmental and neurodegenerative diseases [132]. '
This next study suggests that prebiotic fiber such as inulin is, may be beneficial for the PD microbiome via multiple methods of action :
' The first experiments demonstrate that fermentation of PD patient stool with prebiotic fibers increased the production of beneficial metabolites (short chain fatty acids, SCFA) and changed the microbiota demonstrating the capacity of PD microbiota to respond favorably to prebiotics. Subsequently, an open-label, non-randomized study was conducted in newly diagnosed, non-medicated (n = 10) and treated PD participants (n = 10) wherein the impact of 10 days of prebiotic intervention was evaluated. Outcomes demonstrate that the prebiotic intervention was well tolerated (primary outcome) and safe (secondary outcome) in PD participants and was associated with beneficial biological changes in the microbiota, SCFA, inflammation, and neurofilament light chain. Exploratory analyses indicate effects on clinically relevant outcomes. This proof-of-concept study offers the scientific rationale for placebo-controlled trials using prebiotic fibers in PD patients.'
Inulin, as one of its benefits, increases the SCFA, Propionate. The following is only a PD mouse model study, but it makes an interesting point :
' OCN elevated Bacteroidetes and depleted Firmicutes phyla in the gut microbiota of PD mice with elevated potential of microbial propionate production and was confirmed by fecal propionate levels. Two months of orally administered propionate successfully rescued motor deficits and dopaminergic neuronal loss in PD mice. '
In any case, reintroducing the inulin to the PS-128 yogurt in an appropriate amount seems at least worthy of consideration if you are not already doing it.
Hello Art ~. Thank you so much for your information!! It is extremely timely. My husband is starting to have a little bit of constipation issues and I was going to look into some other gut things so thank you very much for bringing this to my attention! I will definitely look into adding inulin to his yogurt since I did not know that!!!
Hi Art ~ I did but not long enough to run a good trial because my HwP is having increased symptoms. For the short time he used the inulin I did have him add the inulin powder after I had made the yogurt instead of adding it in. I also had purchased inulin made from Jerusalem artichoke rather than chicory since it seemed to have more nutrients and is organic. I don’t know if it makes a difference or not.
We are addressing other issues at the moment. (I can go into more detail if you’d like.) He is still taking the caps of the BenedLife Neuralli PS128.
Have a fabulous day and thank you for checking in!!
Hi Lizzy9 Thank you so much for sharing your PS128 yogurt making journey. How are you getting on? I'm planning on making this for my hubby with Parkinson's. Previously I've followed Dr William Davis recipes from his book Super Gut to make l-reuteri yogurt. He recommends 36 hours cooking time for optimum success, using probiotic starter (or 2 tablespoons of your previous batch of yogurt) plus 2 tablespoons of prebiotic fibre (inulin or raw potato starch) added to 950ml of single cream or other liquid. I use a Luvele yogurt maker. Looking forward to your update. Many thanks
Hello 1honeybee ~ I’m sad to say that I quit making the PS128 yogurt. I had a couple of batches fail. I decided that was too expensive since I was organic (and possibly A2A2). I’ve had too much going on to continue. I have no idea what went wrong because I did everything exactly the same.
I have kept my husband on Bened Life PS 128. It helps him so much that it’s one we will continue!
I have enjoyed reading a few of your posts recently and I would like try taking the PS128 and making the yogurt as well. I have an instant pot and I too use A2A2 (grass-fed, organic) milk so my plan is to try it with that, although I haven't made homemade yogurt for years.
I'm curious where you buy the PS128? Are you in the US? I found the supplier, Bened Life, I think they are in Taiwan and not sure yet about shipping costs but the PS128 is very expensive, if I remember correctly it was $165 for 1 bottle and they offer a "deal" if you buy 3 bottles for $346 I think. If it works I'm fine paying higher prices and I know there's no way of knowing until I try it, but whew, that's a lot! Just wondering if that's the kind of price you are paying for it?
Hello Victotia! Yes, I give my HwP Bened Life PS 128. I took him off of it due to cost (and suggestion by a health care practitioner). Within three weeks his anxiety and tremor skyrocketed. Fortunately when back on it within a week it was working again. For us the cost is definitely worth the cost!!!! At the beginning it took 2 ½ months to see results. I’m on auto ship every three months. It’s almost $300 every three months and yes, I’m in the US.
Recently we had HwP take it at night with his last batch of meds/supplements instead of taking with breakfast. Hasn’t seemed to make a difference.
He still has tremors but seldom anxiety so this is a game changer for “us”!! And maybe it does help his tremor but DEFINITELY helps with anxiety. And he is on prescriptions as well as a bunch of supplements.
Great! Thank you! Also curious, have you tried making the yogurt with it again successfully? I read that you were having failures, likely due to them changing the formula, ( inulin)?
I gave it up. It was just too expensive for failures. I don’t remember now if I ever got around to adding the inulin. I’ve had too much going on to keep messing with it.
Very recently I’ve started him on Albert’s Broccoli Seed Tea. So we’ll see….
I can buy A2A2 grass-fed organic full-fat plain yogurt in my area, not sure it will save me money to make my own because the milk is expensive also, but will definitely be easier to buy it! I can just add inulin, and take the PS128 capsules.
I want to try Albert's BS tea also! I haven't yet purchased "the lab supplies" I'll need to make it, or the seeds for that matter but I have located the right ones. Has it been fairly quick and easy to make, or complicated? It sounds pretty easy once you get the steps down. I'll look forward to hearing your husbands results.
We also have A2A2 yogurt, (milk, ½, and cream when I’m missing those).
Before I started the BST I bought everything on Albert’s list. Didn’t need all that! I use my stove, shot glasses. I did buy a small insulated water bottle, two glass Celsius glass thermometers. I already had a scale. And our local co-op had the correct mustard seeds. It does take a little time. But if it works!!👏🏻👏🏻👏🏻. It will be well worth ALL the effort. Albert has recently discontinued taking the BST ( I don’t know if he’s quit permanently or not) but his symptoms didn’t return. (And I don’t know how long he’s discontinued it.) I think he’s taken it for four years. If this works for my HwP we’ll seriously address his tremor ~ back issues are causing a lot of problems for “us”.
Ok! Gives me incentive to get busy with that project!!
I don't really have tremors but I do have anxiety, and lately my worst thing is increasing "off" time whenever I eat anything because food interferes with either the 3 pills of 25/100 C/L or the 8 doses of mucuna powder that I take throughout the day. They always say it's protein but it seems to be just about anything for me, except maybe fruits and non-starchy vegetables eaten plain.
During those off times it's as if someone pulled the plug on me. I get extremely weak, in body and mind, and can't really function well, read, make decisions, or even listen to a book or podcast. I'm so distracted by how my body becomes so very uncomfortable, a phenomenon that is hard to explain, it's not really pain but it is pretty unbearable, almost like an internal anxiety that wants to explode but has no way to get out or there is no energy to expend it.
My fine motor skills become incredibly difficult, I shuffle and walk very slow, I'm super klutzy (and normally quite the opposite), my strength, balance and energy are just gone. Magically though, and thankfully it all comes back eventually and you'd never know I have PD. It is a very strange thing.
Yes, in between, but I need to take one or the other (C/L or mucuna) every 2-3 hours so it gets challenging to time it all to try and avoid those off times. I have a neuro appt with a new Dr the end of March, so he will likely want to make Rx adjustments, although I prefer the things I can do myself, or for myself, holistically vs add to an Rx cocktail with their bevvy of side effects. I haven't had great luck with neuro docs, they (all but one and he closed his practice and moved away) have been either condescending, arrogant know-it-alls, completely not interested in anything except what they learned in medical school, don't like their patients to do their own research, and none of them look at any of the new developments or stay up with current research unless it's about new drugs or DBS. There are a few good ones out there, just not near me!
I don't think caffeine bothers me, I drink strong, dark roasted, 3rd party tested mold free organic coffee, black and only 1 cup, sometimes 2 and only in the morning. I've gone off of it periodically and don't notice any changes.
Yes, PD is a very unforgiving and unfortunate affliction and my hope is that interest and research related to it will continue to escalate as it seems to be doing recently, especially since it is now supposedly the fastest growing neuro disease! We also know what the causes are, we just need to get everyone on board to change those things, like pesticide use, etc so we don't continue to create the perfect storm for it to occur. Ditto for cancer and more, where environmental toxins are big players!
Ok, off my soap box! I'll probably be censored here for all my opinions, I got on a roll. It's been great discussing things with you, thank you for all your knowledge and answers. Your husband is a lucky man to have you helping care for him, it is not an easy job. Take good care of you too.
Someone here just recently posted (I can't remember who) that Albert Wright had passed away a week or two ago. So sad, his work, and his newsletters are invaluable!
Interestingly I got an email this morning that appeared to be from him, describing his work, asking if I wanted to subscribe to his substack, which I already have. He was also recommending another writers work, a midwestern doctor that he himself subscribed to titled, The Forgotten Side of Medicine, where this person will be exposing the corruption, malpractice and cover-ups in the world of bigpharma and medicine, and share remarkable therapies lost to time. If Albert has truly passed, it seems weird that he would be recommending someone's work as well as still recruiting subscribers to his own?
Anyway, it looks like you were communicating with him there about the BST, and he said he was coming out with a streamlined version for preparing it. I was wondering which version you have been making?
I received my Bened, so I've started on that and see how it goes. I've been taking one capsule in the morning and one in the evening. I've had worsened restless legs the last couple of nights, not sure if it's related to the Bened, but I may take both in the morning to see if that improves.
Hi Victoria! Yes, it was here on HU that I heard that Albert passed plus another member I communicate with told me.
I really don’t know whether or not I’m using the “streamlined” BST recipe or not. I’ll be happy to tell you what I’m doing, however the jury is still out as to whether or not it’s helping my HwP or not. We’re about at the ½ way mark of seeing positive results. I have no idea if I’m doing it totally correct or not.
PS 128 ~ it was pointed out to me that it’s recommended (I guess) to take two caps at night/bedtime so I had him switch to nighttime . I was having my hubby take with breakfast. His tremor is awful so I’m going back to him taking them in the a.m. He takes a “handful” of pills at 6 a.m. so I think I’ll put them with that batch. He’s always taken the two at the same time so whatever time you take them I would think together is best. But ~ who knows for sure?
Let me know how it goes!! And remember that it takes quite a while before you see results.
I know it will take time to (hopefully) notice improvements. It was weird about my restless legs, it easily could have been caused by something else, it just coincided with starting the PS128, so that was the obvious culprit. Bened stresses to be consistent, that when you take them doesn’t really matter.
Sure I’d love to hear how you’re making BST. What I remember as most important was getting the right broccoli and mustard seeds, and then brewing at the proper temperatures. No hurry for your method, I’m not quite ready to start this yet.
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