Parcopa orally disintegrating

[enjoy2013]

Parcopa carbidopa levodopa orally disintegrating: anybody familiar with this one?!

[LagLag37]

Parcopa is the first form of C/L I started using. It is basically the same as the regular C/L but is disintegrating (it didn’t taste bad either it was kind of minty). You put it under your tongue and it dissolves. It’s a way of getting the levodopa in your system a little faster. I used it for several yrs but the manufacturer quit making it and my system wouldn’t deal with another manufacturer. My neurologist and my pharmacist said that can happen even though there’s a very little % of ingredients that are different. If your neurologist is suggesting it, go for it. 🥊

[Kingsdaughter1]

Due to having gastroparesis, in which it was thought that my stomach could not handle oral meds, I was placed on Parcopa, as it is absorbed through your mouth, bypassing the stomach. It worked very well for me. I actually wondered why all PD patients taking carbidopa/levodopa weren’t put on this instead as the absorbency is much faster than the oral pill.

[LagLag37 in reply to Kingsdaughter1]

Kingsdaughter1

Are you still taking Parcopa? Can you check what mfg it is? Thanks!🥊

[Kingsdaughter1 in reply to LagLag37]

No, I have not been on it for several years now. Sorry I can’t be of help with a manufacturer.

[enjoy2013 in reply to Kingsdaughter1]

I also have some gastroparesis leading to very significant fluctuations. I was dreaming about a formulation bypassing the stomach. I wonder where I could buy it

It would be a game changer for anyone having gastroparesis. It would be super important to track where to buy it or how to manufacture it

[Jana86 in reply to Kingsdaughter1]

I will be entering the hospital for heart surgery this week and have been working with my neuro doc on ways to attempt to keep my dopamine levels somewhat steady through what may be a 6 hour procedure. I will be on a vent that may cause esophageal injuries. She suggested the Neupro patch and Parcopa. My local pharmacy (Walgreen's) looked throughout their system for Parcopa but it does appear to be unavailable in the US. My neuro has said that the manufacturer has ceased production due to inadequate sales...Parcopa was not viewed by patients or docs as "equivalent" to Sinemet, but as a less effective choice.

AbbVie, a major pharmaceutical company in the US has resubmitted for FDA approval after a very successful phase 3 trial, a sub-cutaneous pump that could change our lives, I think. Like an insulin pump, it will allow for minute adjustment of quantity and timing and will completely bypass the digestive system. Coming in 2024 if all goes well...this is a second FDA submission. FDA raised some issues last year and the company says those concerns are fully addressed. This could be a real game changer for women....see this week's No Silver Bullet podcast to understand why women struggle with dosing on Sinemet. (I will be using the Neupro patch that delivers C/L for 24 hours during my surgery this week.)

[LagLag37 in reply to Jana86]

Is this Duopa pump what you are referring to? It’s been out for awhile. I know a guy at the gym that just started the pump 2 weeks ago and it did wonders for his tremors, dyskinesia and walking. 🥊

duopa.com/how-duopa-works

[Juliegrace in reply to LagLag37]

Not the Duopa pump! Search some of the posts about it or on google. It may be a real game changer for some of us.

[LagLag37 in reply to Juliegrace]

Have you tried it? I’m unsure reading your reply?

[Juliegrace in reply to LagLag37]

No, it’s not available yet.

[LagLag37 in reply to Juliegrace]

This was on MJF website…..

Duopa was approved in 2015 by the U.S. Food and Drug Administration (FDA) for Parkinson's motor symptoms (tremor, slowness, stiffness). A gel of levodopa and carbidopa, it is infused through a surgically implanted tube into the small intestine, where levodopa is absorbed. (Levodopa is converted in the brain to dopamine, the chemical that goes missing in Parkinson's; carbidopa helps levodopa get into the brain and decreases side effects.)

A portable pump, which can be worn during regular daily activities, infuses Duopa for 16 hours each day. Duopa is most often used in people who experience significant "off" time (when medication is not working optimally and symptoms return) and/or dyskinesia (involuntary, uncontrolled

[Juliegrace in reply to LagLag37]

It’s not duopa. I m not sure how else to tell you that. Please go back and read Jana’s comment.

[Jana86 in reply to LagLag37]

No...this is brand new...will function like the insulin pump for diabetics...infusion through the skin...NO MORE PILLS!! You can find more at news.abbvie.com/news/press-releases/abbvie-submits-new-drug-application-to-us-fda-for-investigational-abbv-951-foscarbidopafoslevodopa-for-treatment-advanced-parkinsons-disease.htm

[enjoy2013]

Thank you Jana86. What a disappointment, I was so looking forward to Parcopa.

Good luck with your surgery!

I will check the webinar you mentioned.

By 2024 we also hope to get Stanford 's gloves

[Jana86 in reply to enjoy2013]

And the final results of the Exanetide phase 3 trial...should be a hopeful year!