levadopa subcutaneous pump

[saraoutwest]

C/L works well for me …..when it works. I have a lot of problems with gut absorption. Not only does protein seem to be a problem, but just eating in general inhibits the medicine working well. I need to take simemet every 2-3 hours, so mealtimes are a nightmare. I’m very much hoping that the new subcutaneous pump (not the pump into the stomach) which I believe is just waiting FDA approval will be a godsend for me.

Does anyone have any info/thoughts on this new method of levadopa administration?

[Jalia]

Interesting to read. My husband finds that eating other than a snack makes him feel bad.....inhibiting his sinemet working

[pdpatient in reply to Jalia]

Same with me as well.

[caitilin in reply to pdpatient]

Same with me. My GP dismisses my reports of symptoms returning within just a few minutes after I eat anything; within the 1 to two hour “window of nutrition…”. 😬

[Jana86]

I am waiting for the subcutaneous pump as well. AbbVie is the manufacturer. My understanding is the clinical trials are complete and show both efficacy and safety. Users love it as it provides steadier uptake and completely avoids the digestive track. The FDA has not asked the company for further testing but has some issue with the pump itself. They are saying the release date could happen sooner but most likely summer of 2024.

[kleighclark]

I am so looking forward to it’s approval so I can get back to eating enough protein! I work out almost daily but because of my lack of protein it’s difficult some days. I’m in year 9 of being diagnosed. From what I’ve read, the FDA has pushed back with a couple questions but I can’t remember where I read it.

[cjCardio53 in reply to kleighclark]

Me too. "waiting" for the Abbvie pump 951. I also read 2024. Neuro Derma Pump "said" their pump ready 2023????

[Hikoi]

Gidday Sara,

I know quite a bit about pumps but only 2 nd hand. Never heard of a levadopa pump. The NZ parkinson friends fb site has quite a few on the apomorph pump which is sub cutaneous. The levadopa infusion is different. It involves an op and a gastric tube. It was trialled in nz over 10 yrs ago and rejected. I’ll have to check what you refer to but i’m afraid Pharmac wont approve for years even if the US agency does.

Im off so wont write more just now.

[pdpatient in reply to Hikoi]

Hi Hikoi,

Yes, the pump that you are talking about with the gastric bypass was a poor solution because of the high risk of infection.

The new subcutaneous pump is more promising because it acts just like the apokyn pump. I am waiting for it.

[cjCardio53 in reply to pdpatient]

Me too, waiting....

[Juliegrace in reply to Hikoi]

There are two pharma companies with subq pumps in development. Both have gotten to phase 3 trials but only one has applied for approval. That is Abbvie. The other company is Neuroderm. I’ve been waiting for them for over four years now.

[cjCardio53 in reply to Juliegrace]

My neuro said last week, it may be on the market end of 2024..then it will be expensive , cuz it's new...I am looking forward to this

[WinnieThePoo]

DIVE, currently in phase 2 testing by CHU Lille is the one I find interesting, although it's grindingly slow development even by normal PD standards. Well, it is La France (refer to Micky Flanagan for an evaluation of that nation by an Anglo saxon)

eurasante.com/news/actualit...

its a pump fitted below the skin, refilled every 7 to 14 days via a syringe which pumps dopamine, NOT levadopa direct into the substantia nigra. it does involve brain surgery but it is simpler than DBS

Projected clinical availability -2028 I believe . But good to have in the pipeline for then. (Meantime I'll replay the MF video)

[WinnieThePoo in reply to WinnieThePoo]

Looks like they may complete a phase 2 this week!

ichgcp.net/fr/clinical-tria...

Just 1500 more lunch breaks to launch😪

[Koalas007]

hi I’m making one treatment similar with this new one call Apomorphine it’s wonderful