Phyllodulcin — a natural sweetener found in the hydrangea plant - inhibits Aβ accumulation and decomposes the pre-aggregated Aβ in mice.

[JAS9]

Although this study was for AD, Aβ accumulation for AD is similar to misfolding proteins thought to be associated with PD. From the article:

"The study demonstrates that phyllodulcin inhibits the aggregation of amyloid β (Aβ), a main cause of AD, and decomposes existing Aβ clumps. In an animal model, phyllodulcin reduced memory impairments, decreased deposition of Aβ in the hippocampus, and minimized neuroinflammation, key factors in AD.

"These findings suggest that phyllodulcin could offer a promising new avenue for AD treatment.

The study indicates that phyllodulcin, a natural sweetener, inhibits amyloid β (Aβ) aggregation, a leading cause of Alzheimer’s disease, and decomposes pre-existing Aβ clumps.

The research used both in vitro (cells) and in vivo (animal model) experiments, demonstrating that phyllodulcin also prevents Aβ-induced neurotoxicity.

In an AD animal model, phyllodulcin reduced memory impairments, decreased Aβ deposition in the hippocampus, and minimized neuroinflammation, all critical elements of AD.

Source: Sahmyook University"

labiotech.eu/trends-news/ph...

[Gallowglass]

Could be good news.

Where can se find hydrangea sweetenner

[JAS9 in reply to Gallowglass]

I've been investigating, looking for a source for phyllodulcin.

Phyllodulcin apparently comes from the hydrangea leaf and not its root which seems to be much more commonly used in teas and herbal remedies. So, don't settle for the root, which has other good things in it, I'm sure, but not the specific molecule we are looking for.

I found a description of the process someone might be able to use in order to produce their own Phyllodulcin, but it seems very complicated and I'm sure beyond the abilities of anyone but a bio-chemical engineer. So, probably not the approach we should take.

The best bet, then, is to find it already made and available for a reasonable price. It's not in any medications yet, so that's out too. What kind of company would have enough of it for sale? Phyllodulcin isn't hugely popular yet, but it does have one useful property; it's an ultra-low calorie sweetener. Unfortunately, the Steva and Allulose low-cal solutions seem to be this market's leaders and I haven't found any products that use phyllodulcin as a sweetener instead.

But don't give up hope!! I finally have some good news! This Japanese company is trying to get others interested in using it in their products. So, this might lead to something:

jbmarket.jp/eng/products/de...

Please let me know if you are also thinking of contacting them to ask for a price. We will have better luck working together.

ALSO, if that doesn't work out for any reason, I've found two labs that advertise Phyllodulcin for sale. My limited experience with a similar lab is that they would be very expensive and would provide very small amounts:

biochempartner.com/21499-23...

bocsci.com/product/phyllodu...