This is the link I shared regarding the relationship between low lymphocytes (lymphocytopenia or lymphopenia) and PD. I think this helps to explain some of the disparity of responses to meds, supplements, etc, as well as differences in long-term prognosis.
nature.com/articles/s41531-...
Take a look at the graphs in the "Discovery Cohort" section.
From the abstract:
"Patients with sporadic PD and GBA-associated PD showed a significantly lower lymphocyte count, a non-significantly higher neutrophil count and a significantly higher NLR than HCs. The peripheral inflammatory immune response of patients with LRRK2-associated PD did not differ from HCs. Our study supports the involvement of a peripheral inflammatory immune response in the pathophysiology of sPD and GBA-associated PD. However, this inflammatory response was not found in LRRK2-associated PD, probably reflecting different pathogenic inflammatory mechanisms."
We need to look harder at gut health, immune response, inflammation.
FYI, my lymphocyte/neutrophil/monocyte profile is almost identical to what's shown in the graphs for sPD (sporadic). I haven't done genetic testing for PD, but will be doing that sometime soon through parkinson.org/advancing-res... (waiting on my testing kit). I'm the only one who has had PD in my extended family (great grandparents, grandparents, parents, 12 aunts/uncles, 27 cousins, etc.), but my paternal grandfather had ET at 70, and a first cousin on the maternal side (71 y.o. male) may have ET. I'd love to know how I got so "lucky" lol. My current guess is exposure to toxins.