Different PD etiologies = different immune issues = different responses to interventions

[1LittleWillow]

This is the link I shared regarding the relationship between low lymphocytes (lymphocytopenia or lymphopenia) and PD. I think this helps to explain some of the disparity of responses to meds, supplements, etc, as well as differences in long-term prognosis.

nature.com/articles/s41531-...

Take a look at the graphs in the "Discovery Cohort" section.

From the abstract:

"Patients with sporadic PD and GBA-associated PD showed a significantly lower lymphocyte count, a non-significantly higher neutrophil count and a significantly higher NLR than HCs. The peripheral inflammatory immune response of patients with LRRK2-associated PD did not differ from HCs. Our study supports the involvement of a peripheral inflammatory immune response in the pathophysiology of sPD and GBA-associated PD. However, this inflammatory response was not found in LRRK2-associated PD, probably reflecting different pathogenic inflammatory mechanisms."

We need to look harder at gut health, immune response, inflammation.

FYI, my lymphocyte/neutrophil/monocyte profile is almost identical to what's shown in the graphs for sPD (sporadic). I haven't done genetic testing for PD, but will be doing that sometime soon through parkinson.org/advancing-res... (waiting on my testing kit). I'm the only one who has had PD in my extended family (great grandparents, grandparents, parents, 12 aunts/uncles, 27 cousins, etc.), but my paternal grandfather had ET at 70, and a first cousin on the maternal side (71 y.o. male) may have ET. I'd love to know how I got so "lucky" lol. My current guess is exposure to toxins.

[Boscoejean]

With so many toxins out there it seems like they could be affecting people in different ways and you wonder how many health problems are primarily related to exposure to toxins because with so many of them how would a person even know when they are exposed. I did read an article a while back about a possible connection between having had food poisoning and developing Parkinson's. The article suggested that the bacteria can hide out in the appendix and with a recent study finding that Parkinson's was less likely in a person who had had the appendix removed this seems like a possibility.

[1LittleWillow in reply to Boscoejean]

I saw that article too. I had my appendix removed at age 17, so that isn't the smoking gun for me, but I have had a lot of chemical exposures and some severe vaccine reactions. There are a LOT of autoimmune problems in my immediate family.

[Boscoejean in reply to 1LittleWillow]

then add to that possible allergies and things really become difficult

[SAGoodman]

Although there is a wealth of information, the content is waaaaay over my head to understand!