Gut-brain axis: Review on the association between Parkinson’s disease and plant lectins 2022

[Bolt_Upright]

I have been off lectins for quite a while, but recently added tomatoes and catsup (made with real sugar) back to my diet because Marc bought a toaster (so I bought gluten free bread and then started craving a hamburger and a hamburger HAS to have tomato and catsup). Also, I love tomatoes and catsup.

I think all gluten is lectins, but not all lectins are gluten, so maybe some tomatoes and catsup will be okay.

Gut-brain axis: Review on the association between Parkinson’s disease and plant lectins 2022 ncbi.nlm.nih.gov/pmc/articl...

ABSTRACT: Gastrointestinal (GI) involvement in the pathogenesis of Parkinson’s Disease (PD) has been widely recognized and supported in recent literature. Prospective and retrospective studies found non-motor symptoms within the GI, specifically constipation, precede cardinal signs and cognitive decline by almost 20 years. In 2002, Braak et al. were the first to propose that PD is a six-stage propagating neuropathological process originating from the GI tract (GIT). Aggregated α-synuclein (α-syn) protein from the GIT is pathognomonic for the development of PD. This article reviews the current literature from the past 10 years as well as original research found in PubMed on the combined effects of enteric glial cells and lectins on the development of Parkinson’s Disease. Studies have found that these aggregated and phosphorylated proteins gain access to the brain via retrograde transport through fast and slow fibers of intestinal neurons. Plant lectins, commonly found within plant-based diets, have been found to induce Leaky Gut Syndrome and can activate enteric glial cells, causing the release of pro-inflammatory cytokines. Oxidative stress on the enteric neurons, caused by a chronic neuro-inflammatory state, can cause a-syn aggregation and lead to Lewy Body formation, a hallmark finding in PD. Although the current literature provides a connection between the consumption of plant lectins and the pathophysiology of PD, further research is required to evaluate confounding variables such as food antigen mimicry and other harmful substances found in our diets.

CONCLUSIONS: Through EGC-induced cyclic neuroinflammation and oxidative stress, plant lectins may lead to pathological Lewy body formation in the GIT. The Lewy body can then travel retrogradely via the VN to the substantia nigra and contribute to the classic neurologic manifestations of PD. Although the current literature provides a connection between the consumption of plant lectins and the pathophysiology of PD, further research is required to evaluate confounding variables such as food antigen mimicry and other harmful substances found in our diets.

[Sydney75]

Lycopene as in tomatoe paste very benefical for benign prostate hyperplasia.

[WinnieThePoo]

Sounds like the last desperate appeal of the barbeque chef. The list of plants with lectins was pretty extensive. The conclusion that the lectins in vegan diets and the mediteranean diet might make those diets harmful...

Their Dad's are clearly butchers!

[MBAnderson]

Sure, blame the old guy.

I found gluten free bread pretty awful. You?

[Bolt_Upright in reply to MBAnderson]

I got "Canyon Bakehouse 7-Grain Gluten Free". I like it. I got the 18 ounce bag as the 24 ounce bag weighs more but has the same number of slices. I don't need bigger slices.

[Bolt_Upright in reply to Bolt_Upright]

BTW: "Canyon Bakehouse 7-Grain Gluten Free" is at Walmart.

[Jbeaner in reply to Bolt_Upright]

I enjoy canyon bake house 7 grain bread also.

[reedboat2]

Try GF baguettes from Against the Grain. Can be found at Whole Foods Markets frozen foods section. Yummy!