2 week drug study that pays 5,683.33 for volunteers with PD

[bassofspades]

I signed up for this study. The jist of it is, they have a new drug that reduces off time. They already established safety and dose, etc, in previous studies. This study is only to compare the absorption differences or similarities between taking one 15mg pill vs 3 x 5mg pills. Thats all. Pays $5,683.33 and you just have to stay at their facility in Orlando Florida for 15 days.

If you are seriously interested, send me a private message. I will answer whatever questions I am able to and tell you how to get in touch with them.

Why is this study being done?

Cerevel has begun a study of a study drug called CVL-751 Tavapadon

en.wikipedia.org/wiki/Tavap...

(referred to in this

document as the “study drug”) to possibly treat Parkinson’s disease. A study drug is one that has

not been approved by the United States (US) Food and Drug Administration (FDA).

You are being asked to take part in this study because you have Parkinson’s disease. This study

involves research, which means that its purpose is to get information to advance science and

medicine, as opposed to providing you with treatment.

Your participation in this study is voluntary. If you do not want to take part in the study, your

decision will be respected. If you decide not to take part in this study, you can continue with

your current medical care.

The main purpose of this study is to evaluate if two different formulations of the study drug

(TAV-751) are equally absorbed when taken into the body (bioequivalence). This study will

compare blood level exposure between three 5 mg tablets (15 mg dose) to a single 15-mg tablet

in participants with Parkinson’s disease.

The study has been reviewed by Advarra Institutional Review Board (Advarra IRB) and any

necessary regulatory agencies, such as the FDA.

This is from the original email they sent me with all the info about where to inquire -

We have a new study that includes the following:

Volunteers with Parkinson’s Disease Needed for a Research Study

2 outpatient visits followed by 15-night in-house study 1 phone call

Up to $5,683.33 compensation for qualified participants.

[Hidden]

cerevel.com/wp-content/uplo...

[Rafiki2]

Hi Bassofspades

Well done on signing up for this study. I only wish we were in the Orlando area as I would really wish my wife could sign up for it too.

I have been following CEREVEL/Pfizer's TAVAPADON for a while now and it sounds really promising. Please post us your findings once you end the study. It sure sounds like they are close to final stages. Keeping fingers crossed.

[Angelhawk]

I live in Orlando and am interested in participating in this study. Please give me the contact information. Thanks.

[bassofspades in reply to Angelhawk]

i will send it in a private message

[Myfatcat in reply to bassofspades]

Please send me info on the trial tav751. I would be most grateful.

[BeedieBird]

My neurologist recommended me for this study, they are enrolling where I live as well, Kirkland, WA. No money for me though. They are in phase 3 of clinical Trials. Here is info on the clinical Trial and places that are enrolling for Phase 3 clinicaltrials.gov/ct2/show...

[bassofspades in reply to BeedieBird]

Actually I think that part is done. This study that I am talking about has no placebo. It's to determine if one 15mg pill works the same as 3x5mg pills.

[BeedieBird in reply to bassofspades]

Phase 3 Trials are just beginning recruitment, Feb. 2023, and go into 2024 - 27 weeks to compare what they are comparing in your trial the different dosages, including placebo. I'm surprised there is no placebo in your trial, which sounds like Phase 3, comparing difference in dosage amounts, as in Phase II they usually receive the same amount of the drug.

[BeedieBird]

Oh I see now, yours is actually the same amount, but taken differently, at once or split up

[Myfatcat]

Tav751 please

[bassofspades]

Update - the people who are doing this study told me that if you are interested but not in the Orlando Florida area, they may cover travel expenses for you and your caregiver. PM me if you're interested.

[Smittybear7]

I'm interested in hearing more about this. Can you stay on current meds and supplements?Not sure how to PM you.

[bassofspades in reply to Smittybear7]

they’ll let you stay on current meds but they asked a lot of questions about the supplements. Ultimately they let me stay on them. I take lithium orotate, b1 magnesium for pd and vitamin k (for nosebleeds)

[bassofspades]

I did 2 visits for preliminary testing and interviews and so far they paid me $366. Next Week I start the lowest dose of the drug. After a week I will advance to the next dose. After a week of that dose I go to stay at their facility for 15 days and take the final dosage there. Then I go home and they do one follow up phone call. If I do the whole thing I wind up making about $5870 because I went back one extra day to redo the preliminary testing due to timing issues. You have to be able to start taking the medication within a certain time frame and I had a conflict with my schedule so we started over.

[bassofspades]

update

First day taking the medication.

I took one fifth of a dose of the medication for the trial. They start low and titrate up over two weeks. Got such a miserable headache that I am going to discontinue it. Headache persisted for over 24 hours, 3 rounds of Tylenol and 2 rounds of ibuprofen. Still lingering headache, feels like I’m hungover.

They said headaches are common but stop happening after 3 days usually. I don’t think I’m going to stick around. I think I need another round of headache medicine before I go to bed.

[bassofspades]

on a side note, they were grateful for the lecture that I gave them on lithium orotare supplementation! Great people there.

[Boscoejean]

so did you end up dropping out of this study?

[bassofspades in reply to Boscoejean]

Yes I dropped out. The meds gave me a bad headache similar to the tyramine/cheese effect when I used to take ropinerol or selegeline, which are MAO inhibitors.

ncbi.nlm.nih.gov/pmc/articl....

[Boscoejean in reply to bassofspades]

too bad it caused problems but it seems like most medications can have some problems with side effects and I imagine you had some hopes of this being helpful

[bassofspades in reply to Boscoejean]

Helpful schmelpful! I just wanted the money! I knew it wouldn't work, I was just hoping to skate through without the side effects. They still paid me about $750!

[Boscoejean in reply to bassofspades]

well I am glad they paid you and as usual disappointing