Too much interesting stuff in this article: somaticmovementcenter.com/r...
The difference between exercise and "forced" exercise seems to be important.
And then there is a lot of other random interesting info on successes in improving.
Forced Exercise and Stress Reduction Reve... - Cure Parkinson's
Forced Exercise and Stress Reduction Reverse Parkinson’s Symptoms
Written by
Bolt_Upright
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excellent article Bolt. Thank you!
Agree. Lots of interesting info in this article. Too much to read in early a.m. Bookmarked to read later. Thanks for posting.
Good find. I was previously trying a form of forced exercise on my static bike by pedalling to music at a brisk tempo. You've prompted me to get back to it.
”the most important aspect of the exercise is that the person must be exercising at a faster rate than they would choose to do on their own. He recommends reducing resistance so that speed can be increased.”
When I first read how Howard’s symptoms went away quite suddenly, I wondered what the scientific explanation could be. As I learned more about the progression of Parkinson’s and how motor symptoms appear at a critical threshold of dopamine production/neuron loss (estimated to be between 30% and 60%), it made sense. When people are able to boost their dopamine levels/number of neurons back up to that critical threshold, it is possible that motor symptoms may disappear just as suddenly as they started
***critical threshold ***
I like your "critical threshold" theory!
critical threshold is mentioned in article....
Darn… Article is taking up 1/4 of my laptop screen for a stupid header…. 😡 Print is large enough that I can zoom out and still read, but zoomed out only losing 1/8 of screen...
I love my laptop and the high resolution, 2560-by-1664,13.6" internal display, but I spend more time looking at my external. It is only 1080p, but the screen is 23", and very easy on the eyes.
What I would like is a thirty-inch or larger screen with 5k resolution. Then I could configure large type and lots of it on one screen.
”Reduced physical activity is likely an early symptom of Parkinson’s disease. But neuroscientists at the University of Texas in Austin did an interesting study to explore whether or not a reduction in physical activity also speeds up the degeneration of dopaminergic neurons. By restricting the movement of rats, they were able to show that the restriction of movement led to severe and chronic loss of dopaminergic neurons and impaired motor function. Neurons that aren’t used tend to wither away and die—this is called neural pruning. When it comes to movement, the principle of “use it or lose it” applies not only to our muscles, but to the health of our brain as well.”
This is why I think mirtazapine brought on hubby’s Parkinson’s as it made him so dozy he wouldn’t get out of bed or move for a good year or so before I got him off it.
Hope humans do too.....
"In 2003, scientists in Sweden demonstrated that neurogenesis occurs in the substantia nigra of adult mice. Their research showed that the type of dopaminergic neurons lost in Parkinson’s disease are actually regenerated throughout life. While the rate of neurogenesis in the substantia nigra is slower than in the hippocampus, if the rate of neural turnover is constant, the entire population of dopaminergic neurons in the substantia nigra could be replaced during the lifespan of a mouse. The study showed that not only does neurogenesis in the substantia nigra occur, but the newborn neurons are then integrated into neural circuits."
Surprised, JohnPepper hasn’t jumped in with something about fast walking.
I will say, fast walking helps me, but falls short of being a cure.....
For those with the ability to fast walk, walk, boxing, biking, and all other physical activity, cheers to you. Others can do chair exercises, stretches and the like to help enhance dopamine release.
Be active in any way you can, to your individual level of ability to keep your mind active, muscles moving, endorphins active to reduce pain and stress to do the best you can for yourself daily while hoping for a cure.
thank you Bolt
Thank you Bolt. Great post indeed. It's inspiring to see John Pepper acknowledged as an actor in this revolution in medicine.
Bravo
To work!
This is an excellent article. Thanks so much!
As for me the biggest improvements have been from High Dose Thiamine (B1) and exercise. I recommend Dap1949’s book and her Facebook Group.
Whether B1 just gives me more energy (reduces fatigue (*)), or I exercise more is debatable.. But on other hand, If I take a break from B1 my Parkinson's Symptoms start returning.
amazon.com/gp/product/B09TZ...
facebook.com/groups/parkins...
(*) The administration of large quantities of thiamine increases the concentration in the blood to levels in which the passive transport restores the normal glucose metabolism in all cells and leads to a complete regression of fatigue. Proven by Dr. Costantini liebertpub.com/doi/10.1089/....
Huberman says hard exercise stimulates BDNF. Mercola says getting heart rate to 90% of maximum stimulates HGH. The first step might be calculating your maximum heart rate. The old standard was 220 minus age. But I found a more accurate method: 0.64 times age then subtracted from 221.The old method had me at 156 max. but the new method has me at 170. I used a treadmill then used a steep hill. While wearing a heart rate monitor both showed my maximum was 170. I do an HIIT workout on a treadmill. I set it at 10% incline and 6MPH speed. Jump on for 30 seconds and jump off for 90 seconds to recuperate. Done ten times.
Forced Exercise for Rat Models, Means Electric Shock if they fall behind. I don't mean to lessen emphasis on exercise, but is the exercise causing increase dopamine or the electric shock. A little external DBS... LOL...
"Vigorous, forced exercise" means electric shocks if you slow down on the treadmill???
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Has anyone had success John Peppers theory of reversing Parkinson’s symptoms through fast walking
I've been reading about the benefits of Forced Exercise and exercise rate on bicycles and its effect on PD symptoms.
Here are some articles I got from Google. I'd love to receive reactions to these studies,...
Studies in exercise and PD
https://www.youtube.com/results?search_query=https%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3D4lC_uHBJrcU
breathing exercise and PD symptoms
Work and Stress
Milk and Parkinson’s 
