This has been shared before, but I think it is worth reposting, particularly for new members of this forum.
I have been taking Neuroaspis for several months. As with virtually every supplement I take, I have no idea if it is helpful. Yet, if Simon decided it was worthy of an entire article, it seems like a no brainer to me. Obviously, we should be skeptical about the study because of who funded or conducted it, but what if it does actually stop progression for at least 30 months?
So how are you doing so far? No progression in the few months since you started it?
I don't think my PD has progressed at all in the past year and a half or so, but I'm aware that I could just be in denial and/or receiving placebo effects from a myriad of sources. It might be the Neuroaspis. It might be the Coronet Duo red hat. It might be the Tru Niagen. It might be the high doses of thiamine. It might be the high doses of B complex, especially B12. It might be high doses of melatonin. It might be some combination of any or all of them. The only objective things I can point to is that my golf game is better than it's been for years and my league bowling average has never been higher. As an old retired guy, that is good enough for me. 😀⛳ 🎳 🍺🍺
I have also been relatively lucky in the past year or so with little progression. I also do and take a few things making it difficult to know which are working. My list is however totally different to your with that exception of melatonin. Could that be the one?? Can you tell me how much you are taking and for how long? I’m taking 5mg slow release every night.
I take 60mg most nights.
As Astra7 says, melatonin could be the game changer. I’m sure Art would agree too. Do you take the 60mg in tablet form or liquid, Jim? And what brand and where do you get yours please?
I take six 10mg pills. The brand is Spring Valley. I just buy them at Walmart.
How did you determine the dosage of 60mg? It doesn’t effect you the next day?
Jenny,
In Jim's case, he is likely getting more than the 60 mg he is taking because the red light therapy is also purported to increase melatonin level in the mitochondria at least.
Art
Hi Art
Thanks for that. My husband also uses the coronet as well as the intranasal device, so a good reminder that they can increase melatonin level also. It’s amazing that melatonin is neuroprotective, amongst other things!
I’ve included the link that you previously cited about melatonin being neuroprotective, going back 2 years ago.
ncbi.nlm.nih.gov/pmc/articl...
Hi Jenny,
In one of the two 50 mg studies in PwP, they just barely started to see an improvement in motor symptoms during off times buy the end of the study. In the 10 mg study, no motor symptom improvement was observed at any time. Jim is just slightly above that dose with the 60 mg/day he is taking, plus whatever he is getting from RLT.
Art
Thank you, Art. Your research is invaluable and greatly appreciated.
Jenny
Thanks anyway, Jim, but I’ve just found Art’s ‘Melatonin for Parkinson’s’ post from 2 years ago.
Yes, Art has several excellent posts regarding melatonin. I gradually increased my melatonin dosage because I found those posts persuasive.
Could you tell me where you get your slow release melatonin from please, Astra7? I think you could very well be on a winner here!
I got a script from the gp and the pharmacist makes it up. I’m in Perth.
Many people take fish oil, but usually not enough to get maximum benefit from it. This product contains almost 5 grams of fish oil (4,950 mg EPA/DHA). Studies that have shown significant benefit from omega 3s are in the range of 3 to 4 grams/day and directly in a range that can balance out the negative inflammatory effects of omega 6, so clearly in the effective range to see benefit from fish oil. It seems to be priced in a similar range with better fish oil products, but contains significantly more in terms of other ingredients.
Omega 3s in the right amount can prevent some inflammation from ever getting started via preventing omega 6 from causing release of inflammatory mediators, as opposed to trying to neutralize the inflammation once it is already started and doing damage. A clear advantage of fish oil at a high enough dose to prevent the start of inflammation.
Omega 3s also have antioxidant, antiapoptotic and pro mitochondria effects.
Human studies on the benefits of omega 3s in PD are mixed, but this product is utilizing significantly more than just omega 3s.
Art
The product lists Omega 6 as one of its active ingredients.
Not all omega 6s are inflammatory. The main omega 6s we consume with food is inflammatory and that is where the omega 3s can be of help. On the other hand, this product does contain the omega 6s Linoleic Acid (LA) and Gamma Linolenic Acid GLA, but these omega 6s are thought to have anti inflammatory effects. LA previously was thought to be inflammatory, but more recent studies suggest anti inflammatory. GLA is definitely anti inflammatory.
birmingham.ac.uk/news/2019/....
Art
Chartist -- thanks, but it's not clear that any omega-6 is inflammatory:
health.harvard.edu/newslett...
Yes, the point of omega 6s being inflammatory or not is not yet resolved. The omega 3s interaction with the omega 6s is considered as anti inflammatory and I think a major point of this supplement and that is probably why they are using almost 5 grams of EPA/DHA whereas only 150 mg of LA.
sciencedirect.com/science/a...
Art
Art,
I read the article you cited as mostly agreeing with the Harvard article I cited that omega 6 is good for health. Harvard article:
"Omega-6 fats are not only safe but they are also beneficial for the heart and circulation."
"...eating more omega-6 fats either reduced markers of inflammation or left them unchanged."
Your article:
"studies in healthy human adults have found that increased intake of ARA or LA does not increase the concentrations of many inflammatory markers. Epidemiological studies have even suggested that ARA and LA may be linked to reduced inflammation."
So, I respectfully disagree with your conclusion that the inflammatory or anti-inflammatory effect of omega 6 is "not yet resolved." It is surely resolved: eating more omega 6 foods is a GOOD idea. The only caveat in your article concerns whether a "high" omega 6 diet would inhibit the anti-inflammatory effect of omega 3. Adding a handful of sunflower seeds to your morning bowl of oatmeal is not a "high" omega 6 diet.
Jim (Skidad)
Yes, that was the point of my last reply. Omega 3s and omega 6s compete for the same enzymes and we generally get too much omega 6s and not enough omega 3s unless additionally supplemented with something like fish oil.
The latest studies are showing that omega 6s are good on their own but too much omega 6 alters the ratio of omega 3 to omega 6 and this may block the anti inflammatory effects of the omega 3s. Increased omega 6 ratio to omega 3 has shown a negative health potential while an increased omega 3 to omega 6 ratio has shown a potential health benefit as outlined in this new abstract (Sept. 2022) the impact is represented in terms of increased risk of stroke in this particular study for a high omega 6 to omega 3 ratio.
pubmed.ncbi.nlm.nih.gov/360...
A relevant study quote :
' The present study demonstrates a protective association for total n-3 PUFA, a possible harmful association for total n-6 PUFA intake when adjusting for total n-3 PUFA intake, and a harmful association for a higher n-6 / n-3 PUFA ratio '
This supplement should potentially significantly increase the omega 3 to omega 6 ratio.
I forgot to address your last point about the sunflower seeds. Omega 6 consumption goes well beyond a handful of seeds. Many things we eat contain omega 6s and many cooked foods contain high amounts of omega 6s, so it is hard to maintain a higher omega 3 ratio without supplementing omega 3s.
Art
Interesting. Thanks for sharing. I see it is $52 for 10 ounces, which is 15 servings. Kind of pricey. I also noticed in the article the progression slowed a LOT, but did not stop. But lowing a LOT is good.
I think I will have some of my Cod Liver Oil just sitting lonely in the fridge.
interesting. I take the ingredients separately, but maybe worth a try.
Where did you find it to purchase? I'm not seeing it on Amazon. I wanted to read the label.
I know a friend in Europe said it was not available through Amazon, but I am in the USA and my wife orders it through Amazon without any difficulty.
it is available in Central Europe but it’s expensive and would be a problem to source. My husband can keep taking the supplements separately!
Hi Jim, I am happy to know that you are okay. I think you refer to me. I live in Italy and I don't know why Neuroaspis cannot be purchased through Amazon. However I managed to find a contact in Greece ( evidently Neuroaspis is produced in that country for economic reasons). The email is as follows: " danae. monemvasiou@aniva-int.com". I forward the order of the bottles directly to Mrs. Danae that I receive after a few days from a pharmacist in Athens. I can't tell you if it works because I've been using it for a few months. Best regards.
Interesting! Thanks for posting about this product. I am in the US, and it is not showing on Amazon...???...
Apparently, Amazon is currently out of stock. We just ordered from Gemworth.
would you please send me the amazon link as it is not popping up for me. thx u
hubby takes fish oil, krill oil and hemp seed oil and olive oil for cooking and salads. Does that cover all the ingredients I wonder?
I would add pantethine to that to help the processing of fatty acids
I get mine on Amazon, too
Are these the guys that also claimed success at treating MS with the same product? Always a red flag, IMO.
I would say being consistently and reliably medicated with levodopa has been the key driver of QOL for you over the period you describe (based on what you have written elsewhere).
I agree on all counts, although I hope I am wrong. 🙂 I'm probably putting too much emphasis on the fact that Simon devoted an entire article to this product, which he rarely does. That said, he does point out the red flags and at least warns not to interpret his story as and endorsement. But, still...
Hi jimcaster. The link had a video on the next page, regarding Multiple Sclerosis and myelin sheath. There are people who responded at the end of the information. Thanks.
Having re-read the SoPD, I find it as compelling as anything else I take, have ordered some and am on my 2nd day.
Tanks Jim
But you had told that you are already taking the ingredients separately?
Yeah, but I don't know the balance.
I can no longer buy this and it appears that the company might be out of business. Is anyone in the USA still able to buy it? If so, where?
You know the other day you were wondering which stuff you take works and which doesn't. You should be able to contain your disappointment that this one is gone. Remember Virgils aeneid II "timeo danaos et dona ferentes"
But this stuff is from Greece and they made me pay for it. 😀
I'm sure you can translate the Latin. Beware the bubbles(you need to understand rhyming slang for that one)
This is all I know...
The wonders of a bad Internet translation. I don't recall there being that many Danes at the siege of Troy. It's what one trojan soldier says to another when the Greeks present them with a wooden horse. For my O level I translated it as "I fear the Greeks, even bearing gifts"
For those who have a techical interest in this supplement: Here is the link to their patent patentimages.storage.google... . They cite a study they performed as base for their claims. I hope its of interest
20-100 mg/night of melatonin to stop progression of Parkinson's?
What effect does STRESS have on the progression of Parkinson's disease?Slowing the Progression of PD (adapted from a book)I Believe High Dose Thiamine (Vitamin B1) is Helpful, But I Do Not Believe It STOPS the Progression of Parkinson's Disease. 
Increasing my dose of B1 after 4 years and 7 months
