First Patient Dosed in Phase 3 Trial of Buntanetap for Early Parkinson's

[Farooqji]

The first patient has been dosed in a clinical trial testing Annovis Bio’s buntanetap as an oral therapy for early-stage Parkinson’s disease, the company announced.

The Phase 3 clinical trial (NCT05357989) got started shortly after the U.S. Food and Drug Administration (FDA) gave the company the green light to start recruiting up to 450 patients with idiopathic (of unknown cause) Parkinson’s disease. Recruitment is ongoing at three locations in the U.S.

The trial’s launch was grounded on positive findings from a placebo-controlled Phase 2a clinical trial (NCT04524351) that included patients with Parkinson’s and with Alzheimer’s, another neurodegenerative disease for which the therapy is being tested.

There, buntanetap was found to be safe when given once daily for 25 days at different doses. It also was better than the placebo at improving cognitive and motor skills, including speed of movement and coordination.

parkinsonsnewstoday.com/new...

[Farooqji]

I was wondering whether we can start it on our own ? It can be easily purchased from china without prescription

[RedwoodPark in reply to Farooqji]

Is it sold under the same name as buntanetap?

[Farooqji in reply to RedwoodPark]

It is available with generic name Phenserine

en.wikipedia.org/wiki/Phens...

[PDWarrior1900 in reply to Farooqji]

thank you for the good link

[PDWarrior1900 in reply to Farooqji]

your information is WRONG (thankfully!)---------------------------------------

I've been exchanging emails with the president of the company...

I just got her email this morning on august 31, 2022 ...

---------------------------------------------------------------------

"The history of the drug you read is another drug, phenserine, that failed in phase 3. The drug we are developing is an analog of phenserine that has totally different activity from phenserine."

"Because it came from the same company and the structures look similar, very often people confuse the two Posiphen is NOT phenserine, it has never failed, and it inhibits the translation of multiple neurotoxic proteins. Phenserine is an ACHEI like Aricept, Posiphen has NO ACHEI activity"

Best

Maria

[HekateMoon in reply to Farooqji]

If its same med. Why not?

[jeffreyn]

See also this recent post.

healthunlocked.com/cure-par...

[PDWarrior1900]

thanks for this post put the number of clinical trial sites has been updated to over '40' sites!

I uploaded all of them here with contact info if people want to volunteer:

docs.google.com/spreadsheet...

[Farooqji in reply to PDWarrior1900]

I think everyone for whom the mentioned sites are accessible should avail the opportunity

[LauraYu in reply to PDWarrior1900]

Is the trial only available in the US ? I am in Canada, really want to participate

[PDWarrior1900]

he did provide the evidence -- did you review that link? I just did and it's excellent

[Hidden in reply to PDWarrior1900]

So you will buy the chinese version?

[Farooqji in reply to Hidden]

The Chinese version can be tested from consumerlab.com for verification

[Farooqji in reply to Hidden]

However I a now decline to share the Chinese source, as this has created a misunderstanding

[PDWarrior1900 in reply to Hidden]

right now i'm on so many different therapies (no meds) -- and (thank God) I am seeing VAST improvement in my tremors... I don't know how long this 'grace period' will last... as long as it does... i'm not changing ANYTHING with my routine...

[Hidden in reply to PDWarrior1900]

PDWarrior,What are the different theràpies you are doing? 🥊 laglag. (I changed my username by mistake and haven't been able to figure out how to change it back)

[PDWarrior1900 in reply to Hidden]

(not in any particular order of importance -- i'm throwing the "kitchen sink" at this damn evil disease!)-----------------------------------------------------------

I'm not taking any meds -- my first neuro appt is sept 23rd... I have thousands of tremors daily (internal) ... no disruption in my normal activities...

Last 30 days (since I started using my PEMF mat... my symptoms have greatly improved, particularly with reduction of tremors in my EYELIDS...)

-----------------------------------------------------------

1. Exercise ... 2 - 4 times a week I bike/hike 15 miles to the beach... or go swimming

2. Diet ... I'm on the O.M.A.D. diet (one meal a day) and today is day 160! I've lot a lot of weight!

3. Supplements ... over 30... daily

4. PEMF therapy mat (pulsed electromagnetic frequency therapy) -- I've had other posts telling everyone where they can buy the one i'm using ... $800.00 CHEAPER than Amazon! I paid only $300 for a brand new one... and it WORKS!)

5. Vibration plate machine -- 10 minutes a day

6. Sauna -- I have one at home that I use 2 - 3 times a week, 90 minute sessions

7. Sunlight -- I live in a very sunny climate... I get sun (for around 40 minutes) a few times a week

[laglag in reply to PDWarrior1900]

Thanks! You keep busy, especially with taking 30 supplements a day. That's a hard one to swallow Are there any specific ones that you think are working the best? 🥊

[PDWarrior1900 in reply to laglag]

I take 7 to 10 supplements at a time... no big deal... i just imagine that it's a big bite from a hamburger which is even LARGER... lol... ------------------------

and i'm not being negative ... but i don't have a clue if 'any' of them are doing me any good ... 1) you never know the real 'quality' of these supplements 2) you never know if any of them are conflicting with other vitamins 3) because certain vitamins are 'with food' and others are 'night-time' while others are 'empty stomach' ... i seldom manage to get ALL of them into my body -- correctly -- in any given day ... but i'm doing the best i can ...

good luck to you!

[lamboman]

Anyone from the phase 2 trial who can let us know how efficient it was to fight PD?

[jeffreyn in reply to lamboman]

The Phase 2 results showed that, when taken daily for 1 month, posiphen achieved small, but statistically significant, improvements.

The Phase 3 trial hopes to show that, when taken daily for 6 months, greater improvements are achieved, without side effects.

It is my understanding that the Phase 3 trial will have an open-label extension (duration unknown).

[Farooqji in reply to jeffreyn]

According to the website the completion date of phase 3 is 31 December 2023

[jeffreyn in reply to Farooqji]

Yes, I know. But I don't know the rules for open-label extensions. For example, are open-label extensions permitted to carry on after the main trial has completed?