Ginger root extract more potent senolytic than others

pubmed.ncbi.nlm.nih.gov/353...

journals.plos.org/plosone/a...

Anyone using ginger for this purpose?

[LeharLover62]

No, but perhaps we’ll give it a try. Interesting research…I wonder what dose would be needed?

[Sydney75]

Interesting that Bolt posted on Fisetin which is reported to: Fisetin eliminates senescent cells

Fisetin is probably most known for its impact on senescent cells: studies showed that this substance can reduce the accumulation of senescent cells (R). Fisetin is a senolytic, a compound that can clear away senescent cells.

[Hidden in reply to Sydney75]

I just learned that Fisetin is thought to be a better senolytic than Quercitin. I think both have poor bioavailability. I wonder how to increase the bioavailability?

[Sydney75 in reply to Hidden]

You are right about that, there is a message board devoted to increasing bioavailability. The posters on this board are using very high amounts of Fisetin (not sure why maybe longevity) Liposomal would be the best I think. Some take with bioperine like turmeric, phosphatidylcholine, lecithin to increase bioavailability. Some of this gets overwhelming to me.

In this study below researchers used: 100 mg/kg of fisetin in 60% Phosal 50 PG:30% PEG400:10% ethanol I would not know how to duplicate that combination outside of a lab.

thelancet.com/journals/ebio...

Findings:

Of the 10 flavonoids tested, fisetin was the most potent senolytic. Acute or intermittent treatment of progeroid and old mice with fisetin reduced senescence markers in multiple tissues, consistent with a hit-and-run senolytic mechanism. Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.