Parkinson’s , increased risk for ALS. Expand our research to what benefits ALS because it will benefit PD as well.

Based on sound research, I here posit that PWP are at a considerably greater risk of developing ALS. This is true for both “sporadic” and genetic PD. Furthermore, whether one’s PD develops in to ALS or not, thus far in my research, what benefits a person with ALS will also benefit a PWP. Therefore, I urge and implore my fellow PWP researchers to expand our search for solutions to include ALS research.

[Hidden]

Genetic risk , Sporadic Parkinson’s & ALS

frontiersin.org/articles/10...

[Hidden]

ALS & Parkinson’s, evidence of shared genetic risk. (I do not believe there is such thing as “sporadic” Parkinson’s. Not knowing the cause, genetic or not, does not mean it’s sporadic, it means the cause is not yet known and therefore appears sporadic).

pubmed.ncbi.nlm.nih.gov/793...

[pmmargo in reply to Hidden]

My friend died from ALS so I am interested in it as well, There is a biomarker for it:

neurosciencenews.com/als-te...

Best Wishes!

[beehive23 in reply to Hidden]

idiopathic...

[Hikoi]

Your article reference is dated 1994, it wasnt until In 1997, researchers at the National Institutes of Health made the first Parkinson's genetic connection, discovering that mutations in the SNCA gene were in families. This (a potential link btwn ALS and PD) would have been an interesting finding back then but I imagine we have moved on considerably in nearly 30years.

pubmed.ncbi.nlm.nih.gov/145...

[Hidden in reply to Hikoi]

Thank you for the Parkinson’s Plus info.

Moving on does not always equate to progress it can equate to abandoning a theory. Since you think there is no genetic link between ALS and PD, and we have “moved on” enough in the past 30 years to prove this, I hope you will elaborate further how ALS is not related to PD. Please, proving me wrong would be delightful to me as I have both in my family and would prefer to just have the one and not the other.

[Hikoi in reply to Hidden]

You misread me. I think our knowledge has expanded considerably especially concerning genetics but I never said or meant to imply that there is no genetic link. I’m afraid it is science way beyond my capabilities but I can understand your interest.Here is another reference I havent read fully that may be of interest.

webmd.com/brain/what-are-mo...

[amykp]

Hmm. I have PD (GBA PD, if that means/adds anything to the equation) and both a maternal uncle and great aunt died (horribly) of ALS. I realize it's n of 1, but it's still always intrigued me.

[Hidden in reply to amykp]

My Dad has PD, my uncle died of ALS, my great aunt had ALZ, my grandma had dementia and essential tremor and I have the early signs of PD. I’m guessing this is not all a coincidence.

[ddmagee1]

Having a DNA test would, perhaps, clear up any question, of rather one or the other disorders are inherited. My results, of DNA tests made me feel much better about what I had, and about what I didn’t have!

[SilentEchoes]

At the end of her life, my mom's PD looked more like my ALS. They are known to complex with each other and Alzheimer's.

I strongly suspect they are a spectrum moreso than separate diseases.

It's nice to not be the only voice.

SE