Big pharma puts bets on alpha-synuclein i... - Cure Parkinson's

Cure Parkinson's

26,583 members27,899 posts

Big pharma puts bets on alpha-synuclein in Parkinson’s – but will they pay off?

Farooqji profile image
2 Replies

Several pharma companies think that targeting a rogue protein known as alpha-synuclein could be the key to halting or reversing neurodegeneration in Parkinson’s disease – but has the industry learned from a string of failures in Alzheimer’s? In the space of a few weeks, Novartis AG and Sanofi AS have signed major deals for molecules targeting misfolded alpha-synuclein, the rogue protein thought to be the root cause of Parkinson’s disease

bioworld.com/articles/51555...

Written by
Farooqji profile image
Farooqji
To view profiles and participate in discussions please or .
Read more about...
2 Replies
kaypeeoh profile image
kaypeeoh

Is there any evidence that alpha-synuclein is the culprit rather than an innocent side effect?

jeffreyn profile image
jeffreyn in reply tokaypeeoh

There is clear evidence that alpha-synuclein plays a part.

The full extent of that part is not yet clear.

Not what you're looking for?

You may also like...

LL-37, a natural antimicrobial molecule present in the brain and gut, Suppresses Alpha-synuclein Clumping in Parkinson’s

"LL-37, a natural antimicrobial molecule present in the brain and gut, selectively binds to harmful...

Copper Leads to Protein Aggregation in Parkinson’s Disease

@[213807] found this! Copper Leads to Protein Aggregation in Parkinson’s Disease July 7 2022...

Is Parkinson’s Disease a Prion Disease? Alpha synuclein and prion-like behavior.

Prion diseases are a type of infectious disease transmitted by a self-replicating protein, the...
House2 profile image

More Reason for Cautious Optimism

“The concept is that aggregates of the protein alpha-synuclein, thought to play a key role in the...
jimcaster profile image

Feedback from a PD research scientist in the department of Clinical Neuroscience at the University of Cambridge (UK), on PASADENA Trial...

I am interested in participating in the best clinical trial I can get in to and specifically those...
p-oui profile image