Is anyone taking NMN or NM combined with Trans Resveratrol like Dr. David Sinclair?

I’m presently researching this and am hoping to find personal experience of PWP

Thank you

[Millbrook]

🙋‍♀️Just started

[Hidden in reply to Millbrook]

Hi Millbrook!How is it going so far? Taking with transresveratrol?

May I ask which form you decided on? The market is being rather flooded.

[Despe]

YES!

amazon.com/N-Stac-Nicotinam...

Good one, CC!

[Hidden in reply to Despe]

Despe, I thought you might be! You are so proactive and at the forefront of research! Are you both taking it?

With transresveratrol?

What about the increased cancer risk? I’ve been increasing my melatonin to mitigate that hopefully.

Modern Healthspan is a YouTube channel documenting their personal experience.

[Despe in reply to Hidden]

I am not taking it, hubby is. To counteract cancer risk, it contains Apigenin and Quercetin. I had done extensive searching and I found this supplement.

[Hidden in reply to Despe]

Thank you Despe! If my memory is correct, he doesn’t respond well to B1? In my recent reading, CDP Choline / Citicoline works biologically in a similar way. And there are much more bio available forms of B1 than thiamine. You research so diligently I’m probably not sharing anything new but I wish to reciprocate since you help me so much.

[Despe in reply to Hidden]

You are very welcome! Hubby is responding to B1. We had to experiment different doses just like most of the members here. He started with injections while Dr. C. was alive. Gradually we had to lower his dose and now he is on 100mg (sublingual) divided in two doses.

Instead of citicoline he is on Phospholipids per his ND instructions.

iherb.com/pr/bodybio-pc-com...

[Hidden in reply to Despe]

All your research Despe must be like a part time job! Between homeschooling my kids and my researching “optimum health” I feel like I’m working full time.

When not doing that I’m cooking and exercising!

You have given me something new to learn about.

Thank you!

❤️

[Despe in reply to Hidden]

We always learning something new, CC. I am not working just full time but OVERTIME! Never give up, that is my motto.

[Millbrook in reply to Hidden]

Hi CC. I must have missed something. What cancer risk?We just started 5 days ago.

- Doctors best Transresveratrol 2 capsules- Sinclair takes 1 g

- Thorne resveracel- 2 caps- also supposed to be 1 g dose

But I have decided that Thorne Niacel maybe better so will probably switch to that.

I wonder if transresveratrol apart from being 98% purity should be micronised as well. Just a thought.

Oops. This should be addressed to Despe

[Hidden in reply to Millbrook]

I mentioned cancer riskIt’s not associated with trans Resveratrol but with NMN and NR.

[JBOVERT]

RESVERATROL DOES NOT WOTK I don't know about transresveratrol though

[Hidden in reply to JBOVERT]

Trans Resveratrol supposedly is different. It is used by Dr. David Sinclair.

[park_bear in reply to Hidden]

Don't know about transresveratrol either, but

youtube.com/watch?v=vpxQoGk...(Not working as expected?)

[Hidden in reply to park_bear]

Harvard professor Dr. David Sinclair has responded to this video when asked his opinion with a poop emoji.

[park_bear in reply to Hidden]

It seems like Dr. Stanfield has done a very thorough job going through the research. If that is the best Dr. Sinclair can do I would award the win to Stanfield. If Sinclair wants credibility he needs to say where Stanfield goes wrong. JMHO.

[Hidden in reply to park_bear]

I gather you have not listened to Dr. Sinclair or read his book.I recommend seeking out his research on aging

Just reread my comment: if I sounded snippy I sure didn’t mean to. 🌸🌈

[park_bear in reply to Hidden]

Thanks for the clarification

[Millbrook in reply to park_bear]

Thanks PB

[Robb48]

Interested in this too since coming across this paper:

"Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway"

molecularneurodegeneration....

Direct sirt3 activators are more challenging to find, but have seen papers that claim resveratrol activate sirt1 and maybe sirt3, both of which would be helpful.

I'm not a doctor, but my brother is - medical specialist in a neuro involved field. He thought the above paper was very interesting, and that they may well be correct about the underlying mechanism, but he thought that therapeutics had a low chance of success, given it was based on cell cultures and mouse studies, and real world application is always more complex. Still, I think it is worth a shot - if the mechanism is correct, then that a much better place to start than just randomly throwing compounds around to see what happens. And he's probably a little jaded after seeing so many mouse studied that dont carry over to humans :).

I've personally been taking NMN off and on for the last year or so, but more for anti-aging. My mother has likely MSA (a Parkinsonism) and I'm interested in trying her a range of sirt activators, sirt3 as much as possible, to see if they help. Alas nothing there is cheap... I tried her on NMN and resveratrol in the early stages of her disease but they didnt seem to do much, although there were some issues with the way she was taking them. And the price of NMN has come down a lot in the last year, so I can now feed her more!!

Anyway, will watch this thread to see if others find benefit.

p.s. Resveratrol has very low bio-availability, adding piperine massively improves this.

p.p.s. My own feelings after reading Sinclairs book and many interviews with him, is that he is solid. Resveratrol was criticised a lot in the early days, but Sinclair was later vindicated. Some people just cannot let it go however. Anyway, the research on NMN is moving forward fast now too, youtube channel "My NMN Experiment" is a good one to follow for updates.

EDIT: I bought 1kg (lol) of NMN from "Do Not Age" a while ago as a special offer (still available). And the youtube channel above will give you a further discount code if you look for it (10% I think??). Amusingly I was able to apply both, score!! Could probably sell some on if anyone in the UK wants 100g or so, since I um... have quite a lot now...say 90p/g.

[Hidden in reply to Robb48]

I bc appreciate all the info in your response! Much to learn! Nothing is simple is it but so worth it!

[Robb48 in reply to Hidden]

No problem! Oh, and one thing to consider re taking NMN, is to look up the papers that claim NMN requires sirt3 to do it's job, which is exactly the pathway that is discussed as deficient in the above paper for pwp. So going heavy on the resveratrol might be worthwhile, perhaps even try other supplements to boost sirt3.

[Hidden in reply to Robb48]

Your Mom is blessed you are such a caring son! Regarding resveratrol, trans resveratrol has better bio availability and should be taken with a fat. I did not know about the piperine for increasing bio availability. Interesting! Regarding NMN and NM; I'm very concerned about the suspected or reported increased cancer risk. I'm only 46. I'm thinking I therefore might start with increasing my NAD via a different route; via suppressing the pathway that decreases its production (which is my novice layman's way of putting it). I'm therefore thinking of adding Apigenin and Quercetin to reduce my CD38.

Thank you for recommending that YT channel. I listened to him on my evening walk. Much appreciated!

Then I listened to Lance Hitchings video on Raise NAD+

Now I need to seek out the papers you mentioned on sirt3. If you have them accessible and wouldn't mind linking, I would be very grateful.

P.S. Melatonin is excellent at reducing ones cancer risk. I listened to a talk by a doctor who uses high dose melatonin for his stage 4 cancer patients. So, my thinking is that melatonin could be good to offset the increased cancer risk of NMN.

[Robb48 in reply to Hidden]

When I say resveratrol, I mean the trans version, to the best of my knowledge thats the only one that is sold. In the past when I bought it, I added piperine and mixed it into coconut oil for storage, and then when I or my Mum took it, we could just take 5ml a teaspoon full. Convenient, though I'm not a fan of the taste! I've not looked into cancer risk for NMN in detail, from what I can see the concerns are purely associative, in that "we looked at this one brain cancer and it had higher levels in it" - but that doesnt mean that increasing NAD will cause cancer. Another study I just found in mice showed that there was no difference in lung cancer growth rates. Even if there are some risks, I'm confident the all cause mortality will be lower, and take it myself.Re sirt3, nothing saved, but search for it and you'll find lots of stuff! The first one I linked it pretty heavy duty, part the reason I asked my bro to give it a look over actually