Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2020

[Farooqji]

145 trials are registered and ongoing clinical trials for therapeutics targeting PD, of which 51 were Phase 1 (35% of the total number of trials), 66 were Phase 2 (46% ), and 28 were Phase 3 (19% ). There were 57 trials (39% ) focused on long-term disease modifying therapies, with the remaining 88 trials (61% ) focused on therapies for symptomatic relief. A total of 50 (34% ) trials were testing

content.iospress.com/articl...

[MissRita]

Does anyone know how you get on board for a trial? I would love to be a guinea pig for the stuff but I just don’t know where to start. TIA!

[Farooqji in reply to MissRita]

Go to clinicaltrials.gov, Search for the required trial and contact them as per the contract information provided

[MissRita in reply to Farooqji]

Thx!

[WinnieThePoo in reply to MissRita]

Michael J Fox foundation also have a trial finder site

michaeljfox.org/trial-finder

[MissRita in reply to WinnieThePoo]

Thx!

[redhawk1]

Stay tuned for study results of Phase 1 Denali DNL 151. If I were to get involved with another trial I would certainly consider the Denali Therapeutics Phase 2 DNL151 trial scheduled to begin sometime this year. Also, get a genetic test to determine specific genes that may be responsible for your disease inception.

[Farooqji in reply to redhawk1]

Were you involved in Phase1? How was it

[redhawk1 in reply to Farooqji]

No. I am in Roche Prothena 2b study. But, trial center I attend is also sponsoring the Denali DNL151 phase 1 study. I always try to obtain snippets of information about other studies when I am there. The 5 cohorts taking part in the phase 1 Denali study all had “positive” reactions to the DNL151 medication. Had not heard such an endorsement about any other PD drug in my three years there as trial givers are hesitant to disclose any thoughts . . ., as they should be. Just saying . . .

[Farooqji in reply to redhawk1]

How is PRX002 going. Any improvements reported by the participants?

[redhawk1 in reply to Farooqji]

Diagnosed March/2017 and in year 3 of study. Currently not taking any PD meds. Symptoms have progressed none the less . . . all be it slowly. Roche phase 2b apparently to continue up to 5 years.

[MissRita in reply to redhawk1]

I have been looking to get genetically tested but I’m not sure where or how to do it. Suggestions?

[John_morris71]

Anavex will soon be starting phase2/3 trial for PD using their drug A 2-73 which is a Sigma 1 Receptor. They had good results for PDD (Parkinson's Disease Dementia) and more details will soon be published in a peer review.